Blood Fats May Play a Role in Migraines

Women who get migraines have different levels of certain fats in their blood than women who don’t get these headaches, a small new study suggests.

If confirmed, the new findings could lead to a blood test that could diagnose patients with migraines, the researchers said.

Currently, patients are diagnosed with migraines on the basis of the symptoms they report, said study author Dr. B. Lee Peterlin, of the Johns Hopkins University School of Medicine in Baltimore. “In other words, there is no biomarker or blood test that can help us to differentiate” people who get migraines from those who do not, she said.

The researchers tested the women’s blood samples for a class of lipids that had previously been shown to play a role in regulating energy balance and inflammation, according to the study.

In the study, the researchers examined blood samples from 52 women with episodic migraines and 36 women who did not have any headaches. “Episodic migraines” means having migraine headaches up to 14 days per month; people who have more migraines than that are diagnosed with chronic migraines. The women in the study had headaches about six days per month, on average.

The researchers tested the women’s blood samples for a class of lipids that had previously been shown to play a role in regulating energy balance and inflammation, according to the study.

The investigators found that the levels of lipids called ceramides were lower in the women with episodic migraines than in the women who did not have any headaches. The women with migraines had about 6,000 nanograms per milliliter (ng/ml) of ceramides in their blood on average, compared with about 10,500 ng/ml in the women without headaches.

Moreover, it also turned out that women’s risk of migraines increased with higher levels of two types of a different lipid, called sphingomyelin.

These results suggest that the lipids examined in the study may be involved in causing migraines; however, further study of this question is needed, the researchers said.

In another experiment in the new study, the investigators looked at the levels of the lipids in blood samples from 14 participants, without knowing which of the women had migraines. They found that they were able to correctly identify, based on the blood test, the women with migraines and those who did not have any headaches.

Read more at Discovery News