Scientists have grown bacteria in a very low-atmospheric-pressure environment, similar to the surface of Mars.
When searching for life in the universe, it makes sense to look for conditions roughly similar to our own planet. We have only one example of life, and it happens to exist on an Earth-sized planet with water and a thick atmosphere. Previous studies have shown that microbes were unable to grow when the atmospheric pressure was too low, but a new experiment seems to contradict this finding.
“Just because the planet doesn’t have a large atmosphere, we don’t have to dismiss it right away as non-habitable,” said Alexander Pavlov of NASA’s Goddard Spaceflight Center here at the American Geophysical Union conference on Dec. 3.
Pavlov and his team simulated a Mars-like environment in a large bell jar. It contained a sample of salty dirt meant to mimic Martian soil, was filled with a carbon dioxide atmosphere, and was cooled to low temperatures with liquid nitrogen. They introduced water and E. coli bacteria, a common microbe found all over Earth, into this environment and slowly lowered the pressure.
When the atmosphere reached around 23 millibars — a pressure about 40 times lower than found at the surface of the Earth — the water began to boil away. But enough of the liquid remained even as the pressure dropped that the E. coli were able to hang on and even thrive for a few days. Because the water was not replenished, it all boiled away after several days and the bacterial colony eventually collapsed.
Pavlov thinks that on Mars, warmer seasons such as spring and summer could melt subsurface ice and provide an oasis where hardy organisms could live. During these times, the temperature underground routinely reaches above the freezing point of water and a soil depth of just seven inches provides good protection against harsh ultraviolet radiation. Extremophile microbes, which live in environments far more dangerous than ordinary organisms can handle, could survive such conditions with ease.
Read more at Wired Science
Dec 4, 2012
Gladiator's Tomb to Be Reburied
The tomb of the ancient Roman hero believed to have inspired the Russell Crowe blockbuster "Gladiator," might be returned to oblivion four years after its discovery in Rome.
A lack of fundings is forcing Italian archaeologists to bury again the large marble monument of Marcus Nonius Macrinus, a general and consul who achieved major victories in military campaigns for Antoninus Pius, the Roman emperor from 138 to 161 A.D., and Marcus Aurelius, emperor from 161 to 180 A.D.
Unearthed in 2008 on the banks of the Tiber near the via Flaminia, north of Rome, the tomb, complete with the dedicatory inscription, was hailed as "the most important ancient Roman monument to come to light for 20 or 30 years."
Although the tomb collapsed in antiquity because of floods, its marble columns, carvings and friezes remained perfectly preserved, sealed by the Tiber's mud.
Rome's officials had planned to fully reconstruct the monumental tomb as the centerpiece of a new archaeological park, but the project failed due to a tight budget and a lack of private sponsors.
"It is a painful choice, but we cannot risk losing the monument. The marbles can't face another winter, we must bury the site in order to preserve it," Mariarosaria Barbera, Rome's archaeological superintendent, told the daily La Repubblica.
Born in Brescia in northern Italy in 138 A.D., Macrinus was one of Marcus Aurelius's favorite men. His life is believed to have inspired the fictional character Maximus Decimus Meridius in Ridley Scott's film.
In the movie, Meridus is also a general and a favorite of Marcus Aurelius, but this is where the similarities end.
While Meridius fell from grace after the emperor's death and ended up in exile in North Africa only to return as a gladiator and take revenge, the real Roman general remained a rich and famous man until the end of his days.
Ironically, a lack of money has so far prevented his tomb from being restored in its full glory.
Read more at Discovery News
A lack of fundings is forcing Italian archaeologists to bury again the large marble monument of Marcus Nonius Macrinus, a general and consul who achieved major victories in military campaigns for Antoninus Pius, the Roman emperor from 138 to 161 A.D., and Marcus Aurelius, emperor from 161 to 180 A.D.
Unearthed in 2008 on the banks of the Tiber near the via Flaminia, north of Rome, the tomb, complete with the dedicatory inscription, was hailed as "the most important ancient Roman monument to come to light for 20 or 30 years."
Although the tomb collapsed in antiquity because of floods, its marble columns, carvings and friezes remained perfectly preserved, sealed by the Tiber's mud.
Rome's officials had planned to fully reconstruct the monumental tomb as the centerpiece of a new archaeological park, but the project failed due to a tight budget and a lack of private sponsors.
"It is a painful choice, but we cannot risk losing the monument. The marbles can't face another winter, we must bury the site in order to preserve it," Mariarosaria Barbera, Rome's archaeological superintendent, told the daily La Repubblica.
Born in Brescia in northern Italy in 138 A.D., Macrinus was one of Marcus Aurelius's favorite men. His life is believed to have inspired the fictional character Maximus Decimus Meridius in Ridley Scott's film.
In the movie, Meridus is also a general and a favorite of Marcus Aurelius, but this is where the similarities end.
While Meridius fell from grace after the emperor's death and ended up in exile in North Africa only to return as a gladiator and take revenge, the real Roman general remained a rich and famous man until the end of his days.
Ironically, a lack of money has so far prevented his tomb from being restored in its full glory.
Read more at Discovery News
Dec 3, 2012
Grave Robbers Seek Bones for Voodoo Rituals
Over 100 graves have been dug up in the West African country of Benin, looted by grave robbers seeking body parts for use in magic rituals.
According to a Reuters news story,
Many Americans only think of witches and witchcraft around Halloween. But in many countries belief in witches is common, and black magic is considered part of everyday life. In Africa, witch doctors are consulted not only for healing diseases, but also for placing (or removing) magic curses or bringing luck -- much like many psychics and fortunetellers in America.
A 2010 Gallup poll found that belief in magic is widespread throughout sub-Saharan Africa; on average 55 percent of Africans believe in witchcraft.
Though graves are the most common source of bones, organs and limbs, in the past few years albino children and adults in Africa have been attacked and killed for their body parts. The belief and practice of using body parts for magical ritual or benefit is called muti.
Muti hunting was featured in the 2009 South African science-fiction film "District 9," in which the hero's body parts were sought after by a local warlord who believed that the limbs would give him magical powers. Muti murders are particularly brutal, with knives and machetes used to cut and hack off limbs, breasts, and other body parts from their living victims. Many of the albinos were beheaded, their heads carefully collected and preserved as gruesome good luck charms or for use in rituals.
Throughout most of history, medical knowledge of anatomy was poor and indirect, partly because of fear and taboos against cutting open corpses. The Renaissance brought an emphasis on practical, real-world knowledge, which necessarily meant examining and cutting up the dead.
In Europe, the rise of early medical centers created a strong demand for dead bodies; a few cadavers were made available by royal decree, usually the bodies of condemned criminals. In the 1700s, in fact, dissection was a punishment for serious crimes.
By 1720, theft from graveyards was common in London, England, and grave robbers (or "resurrection men," as they were known) were making a profit digging up bodies and selling them to anatomists and doctors. Among the most infamous of these criminals were Irish grave robbers and murderers Brendan Burke and William Hare, who committed sixteen murders and sold the bodies to a well-known London anatomist in 1828.
Read more at Discovery News
According to a Reuters news story,
"The incident is the most serious case of grave-robbing in the West African state, the world capital of voodoo where most of the country's 9 million residents practice a benign form of the official religion. Authorities in Dangbo, a village 6 miles from the capital Porto-Novo, began an investigation after a mason working at the cemetery said he spotted several masked men digging up the graves, from which organs and skulls were removed. 'The desecration of graves is about money in this region,' said Joseph Afaton, director of the cemetery. 'It is for sacrifices, or for bewitching.'"
Many Americans only think of witches and witchcraft around Halloween. But in many countries belief in witches is common, and black magic is considered part of everyday life. In Africa, witch doctors are consulted not only for healing diseases, but also for placing (or removing) magic curses or bringing luck -- much like many psychics and fortunetellers in America.
A 2010 Gallup poll found that belief in magic is widespread throughout sub-Saharan Africa; on average 55 percent of Africans believe in witchcraft.
Though graves are the most common source of bones, organs and limbs, in the past few years albino children and adults in Africa have been attacked and killed for their body parts. The belief and practice of using body parts for magical ritual or benefit is called muti.
Muti hunting was featured in the 2009 South African science-fiction film "District 9," in which the hero's body parts were sought after by a local warlord who believed that the limbs would give him magical powers. Muti murders are particularly brutal, with knives and machetes used to cut and hack off limbs, breasts, and other body parts from their living victims. Many of the albinos were beheaded, their heads carefully collected and preserved as gruesome good luck charms or for use in rituals.
Throughout most of history, medical knowledge of anatomy was poor and indirect, partly because of fear and taboos against cutting open corpses. The Renaissance brought an emphasis on practical, real-world knowledge, which necessarily meant examining and cutting up the dead.
In Europe, the rise of early medical centers created a strong demand for dead bodies; a few cadavers were made available by royal decree, usually the bodies of condemned criminals. In the 1700s, in fact, dissection was a punishment for serious crimes.
By 1720, theft from graveyards was common in London, England, and grave robbers (or "resurrection men," as they were known) were making a profit digging up bodies and selling them to anatomists and doctors. Among the most infamous of these criminals were Irish grave robbers and murderers Brendan Burke and William Hare, who committed sixteen murders and sold the bodies to a well-known London anatomist in 1828.
Read more at Discovery News
Hppy bthdy txt msng!
Text messaging, or txt msng, if you like, turns 20 today.
Interestingly, the technology that would start a cultural revolution in how people communicate did not originate from some high-tech lab in Silicon Valley.
The world's first SMS text (which stands for short message system) came from an office in Newbury, southern England.
Reading "Merry Christmas" -– and not "Merry Xmas" or ": -) Xmas" -- the message was sent on Dec. 3, 1992, by 22-year-old engineer Neil Papworth of the technology company Sema to a colleague at Vodafone UK who was enjoying a staff Christmas party.
Papworth was part of the team developing a Short Message Service Center for Vodafone UK. Deployed with the first GSM networks, SMS relied on concepts developed in 1984 by Friedhelm Hillebrand of Germany and Bernard Ghillebaert of France.
"I was chosen to go to Vodafone's Newbury offices to install, integrate and test the software and get it all working. Initially the idea was for them to use it essentially as a paging service," Papworth said.
Since mobile phones didn't yet have keyboards, he typed the holiday greeting out on a PC, while the recipient, Vodafone's director Richard Jarvis, received the message using a bulky Orbitel 901, also immortalized as the world's first GSM phone.
"I feel good that I was there and did what I did. I didn't know what would happen with text messaging after that though," Papworth told Discovery News.
Thumb-typed messages did not take the world by storm. During the first years of SMS, and long before Twitter, texting in 160 characters remained a tool for geeks and telephone engineers.
In 1995, GSM customers sent only 0.4 messages on average each per month; by the end of 2000 it was still only 35.
But when text messaging across all networks became possible and pay-as-you-go mobile phones became available, SMS texts rocketed, finding their natural market in young people.
Reports estimated that the total number of SMS sent globally tripled between 2007 and 2010, from about 1.8 trillion to a staggering 6.1 trillion.
Filled with truncated words and acronyms, SMS texts remained the most popular app in 2011, with 8 trillion text messages, or over 15 million each minute, sent.
The most prolific texters appear to be subscribers in the Philippines, who send an average of 600 messages each month.
As for Papworth, he now lives in Montreal with his wife and three kids and work as a software architect.
In past years, he has enjoyed quite a lot of media attention.
"I've given radio interviews, been flown to London with my family for a movie premiere, featured in a Super Bowl ad, been an answer to a Jeopardy question and had many articles written on the achievement," Papworth said.
Read more at Discovery News
Interestingly, the technology that would start a cultural revolution in how people communicate did not originate from some high-tech lab in Silicon Valley.
The world's first SMS text (which stands for short message system) came from an office in Newbury, southern England.
Reading "Merry Christmas" -– and not "Merry Xmas" or ": -) Xmas" -- the message was sent on Dec. 3, 1992, by 22-year-old engineer Neil Papworth of the technology company Sema to a colleague at Vodafone UK who was enjoying a staff Christmas party.
Papworth was part of the team developing a Short Message Service Center for Vodafone UK. Deployed with the first GSM networks, SMS relied on concepts developed in 1984 by Friedhelm Hillebrand of Germany and Bernard Ghillebaert of France.
"I was chosen to go to Vodafone's Newbury offices to install, integrate and test the software and get it all working. Initially the idea was for them to use it essentially as a paging service," Papworth said.
Since mobile phones didn't yet have keyboards, he typed the holiday greeting out on a PC, while the recipient, Vodafone's director Richard Jarvis, received the message using a bulky Orbitel 901, also immortalized as the world's first GSM phone.
"I feel good that I was there and did what I did. I didn't know what would happen with text messaging after that though," Papworth told Discovery News.
Thumb-typed messages did not take the world by storm. During the first years of SMS, and long before Twitter, texting in 160 characters remained a tool for geeks and telephone engineers.
In 1995, GSM customers sent only 0.4 messages on average each per month; by the end of 2000 it was still only 35.
But when text messaging across all networks became possible and pay-as-you-go mobile phones became available, SMS texts rocketed, finding their natural market in young people.
Reports estimated that the total number of SMS sent globally tripled between 2007 and 2010, from about 1.8 trillion to a staggering 6.1 trillion.
Filled with truncated words and acronyms, SMS texts remained the most popular app in 2011, with 8 trillion text messages, or over 15 million each minute, sent.
The most prolific texters appear to be subscribers in the Philippines, who send an average of 600 messages each month.
As for Papworth, he now lives in Montreal with his wife and three kids and work as a software architect.
In past years, he has enjoyed quite a lot of media attention.
"I've given radio interviews, been flown to London with my family for a movie premiere, featured in a Super Bowl ad, been an answer to a Jeopardy question and had many articles written on the achievement," Papworth said.
Read more at Discovery News
Voyager 1 Can 'Taste' the Interstellar Shore
As the 35-year-old Voyager 1 probe gets ever closer to becoming mankind's first interstellar emissary, mission scientists have announced that the probe has now entered a new and mysterious region of the heliosphere nicknamed the "magnetic highway."
The heliosphere is the sphere of influence of our sun -- it is basically a bubble in interstellar space inflated by the sun where all planets and all spacecraft are contained within.
After completing its primary mission of outer solar system exploration many years ago, Voyager 1 (and its twin probe Voyager 2) has been ploughing through the outermost reaches of the heliosphere, rapidly approaching the outermost limit of the solar system -- called the heliopause.
Although data collected by the aging Voyager 1 have been showing strong signs of flying beyond the heliopause, mission scientists at the AGU conference in San Francisco announced on Monday that hopes of an interstellar Voyager 1 are premature.
However, the mission is beginning to "taste" the interstellar shores.
It appears that the probe has flown into a new and unexpected region of the heliosphere where the rush of particles generated by the sun -- that, in turn, form the solar wind -- are carried by the weakening solar magnetic field, pushing against the interstellar medium. The outside (interstellar medium) pressure sweeps back the sun's magnetic field, channeling solar particles into a high-speed "magnetic highway." But high-energy particles from outside the heliopause are leaking into the highway and washing over the spacecraft's instruments.
"Although Voyager 1 still is inside the sun's environment, we now can taste what it's like on the outside because the particles are zipping in and out on this magnetic highway," Edward Stone, Voyager project scientist based at Caltech in Pasadena said in a NASA press release. "We believe this is the last leg of our journey to interstellar space. Our best guess is it's likely just a few months to a couple years away. The new region isn't what we expected, but we've come to expect the unexpected from Voyager."
Voyager 1 has been experiencing the outermost regions of the solar system for several years, hitting the solar system's "termination shock" in 2004. It then blasted into the "helioshieth", a region where the solar wind slowed rapidly and succumbed to turbulence. Most recently, Voyager 1 detected the solar wind particles slow to zero signifying that the probe must be approaching the outermost boundary before interstellar space. At the same time, a strengthening of the magnetic field was detected.
Most recently, a rapid drop in lower-energy particles (originating from the sun) coincided with a noticeable increase in high-energy particles (originating from interstellar space) leading many to speculate that Voyager 1 had officially left the solar system's heliopause. However, NASA scientists aren't yet ready to call Voyager 1 an "interstellar mission."
"If we were judging by the charged particle data alone, I would have thought we were outside the heliosphere," said Stamatios Krimigis, principal investigator of the low-energy charged particle instrument, based at the Johns Hopkins Applied Physics Laboratory, Laurel, Md. "But we need to look at what all the instruments are telling us and only time will tell whether our interpretations about this frontier are correct."
Read more at Discovery News
The heliosphere is the sphere of influence of our sun -- it is basically a bubble in interstellar space inflated by the sun where all planets and all spacecraft are contained within.
After completing its primary mission of outer solar system exploration many years ago, Voyager 1 (and its twin probe Voyager 2) has been ploughing through the outermost reaches of the heliosphere, rapidly approaching the outermost limit of the solar system -- called the heliopause.
Although data collected by the aging Voyager 1 have been showing strong signs of flying beyond the heliopause, mission scientists at the AGU conference in San Francisco announced on Monday that hopes of an interstellar Voyager 1 are premature.
However, the mission is beginning to "taste" the interstellar shores.
It appears that the probe has flown into a new and unexpected region of the heliosphere where the rush of particles generated by the sun -- that, in turn, form the solar wind -- are carried by the weakening solar magnetic field, pushing against the interstellar medium. The outside (interstellar medium) pressure sweeps back the sun's magnetic field, channeling solar particles into a high-speed "magnetic highway." But high-energy particles from outside the heliopause are leaking into the highway and washing over the spacecraft's instruments.
"Although Voyager 1 still is inside the sun's environment, we now can taste what it's like on the outside because the particles are zipping in and out on this magnetic highway," Edward Stone, Voyager project scientist based at Caltech in Pasadena said in a NASA press release. "We believe this is the last leg of our journey to interstellar space. Our best guess is it's likely just a few months to a couple years away. The new region isn't what we expected, but we've come to expect the unexpected from Voyager."
Voyager 1 has been experiencing the outermost regions of the solar system for several years, hitting the solar system's "termination shock" in 2004. It then blasted into the "helioshieth", a region where the solar wind slowed rapidly and succumbed to turbulence. Most recently, Voyager 1 detected the solar wind particles slow to zero signifying that the probe must be approaching the outermost boundary before interstellar space. At the same time, a strengthening of the magnetic field was detected.
Most recently, a rapid drop in lower-energy particles (originating from the sun) coincided with a noticeable increase in high-energy particles (originating from interstellar space) leading many to speculate that Voyager 1 had officially left the solar system's heliopause. However, NASA scientists aren't yet ready to call Voyager 1 an "interstellar mission."
"If we were judging by the charged particle data alone, I would have thought we were outside the heliosphere," said Stamatios Krimigis, principal investigator of the low-energy charged particle instrument, based at the Johns Hopkins Applied Physics Laboratory, Laurel, Md. "But we need to look at what all the instruments are telling us and only time will tell whether our interpretations about this frontier are correct."
Read more at Discovery News
Curiosity Hints at Mars Organics, Perchlorate
NASA's Mars rover Curiosity has discovered complex chemistry on the Red Planet, as well as hints of long-sought organic compounds that could aid primitive life, scientists announced today (Dec. 3).
The Curiosity rover found evidence of chlorine, sulfur and water in Mars dirt studied by its onboard laboratory, as well as organic compounds (chemicals containing carbon) inside its Sample Analysis at Mars instrument. However, the science team can't yet be sure whether these compounds truly come from Mars, or arise from contamination transported to the Red Planet onboard Curiosity.
"SAM has no definitive detection to report of organic compounds," Paul Mahaffy, SAM principal investigator at NASA's Goddard Space Flight Center in Greenbelt, Md., said during a press conference at the annual meeting of the American Geophysical Union in San Francisco.
"Even though [Mahaffy's] instrument detected organic compounds, first of all we have to determine whether they're indigenous to Mars," said John Grotzinger, Curiosity's project scientist.
The announcement came after recent rumors — which NASA attempted to dampen last week — that Curiosity had made a huge discovery on Mars.
The observation by Curiosity involved perchlorate, a reactive compound of oxygen and chlorine that had previously been found in the Martian arctic by NASA's Phoenix lander.
Curiosity's SAM instrument uses a tiny oven to cook Mars dirt samples, then study the gases they give off to determine their chemical makeup. Martian soil samples are placed in the device by a scoop on Curiosity's robotic arm.
When Curiosity cooked the perchlorate in its SAM oven, it created chlorinated methane compounds, one-carbon organic material.
"The chlorine is of Martian orgin, but it's possible the carbon may be of Earth origin, carried by Curiosity and detected by SAM's high sensitivity design," NASA officials wrote in a statement.
The new findings by Curiosity came during the rover's study of a patch of windblown Martian dust and sand called "Rocknest." It is a flat stretch of Mars terrain that is still miles away from Curiosity's first destination, rock outcrop called Glenelg at the base of the 3-mile (5 kilometers) Mount Sharp that rises from the center of the rover's landing site — the vast Gale Crater.
While scientists puzzle out the validity of Curiosity's SAM signals, the rover's other instruments have made curious discoveries, as well, mission scientists said.
Curiosity's arm-mounted tools have confirmed that the Martian soil at the Rocknest site is similar in chemical composition and appearance to the dirt seen by NASA's three other rovers: the small Pathfinder, and golf cart-size Spirt and Opportunity rovers.
Photos from the rover's Mars hand Lens Imager, or MAHLI, revealed that the sand drifts at Rocknest have a crusty surface that hides even darker, finer sand below.
Read more at Discovery News
The Curiosity rover found evidence of chlorine, sulfur and water in Mars dirt studied by its onboard laboratory, as well as organic compounds (chemicals containing carbon) inside its Sample Analysis at Mars instrument. However, the science team can't yet be sure whether these compounds truly come from Mars, or arise from contamination transported to the Red Planet onboard Curiosity.
"SAM has no definitive detection to report of organic compounds," Paul Mahaffy, SAM principal investigator at NASA's Goddard Space Flight Center in Greenbelt, Md., said during a press conference at the annual meeting of the American Geophysical Union in San Francisco.
"Even though [Mahaffy's] instrument detected organic compounds, first of all we have to determine whether they're indigenous to Mars," said John Grotzinger, Curiosity's project scientist.
The announcement came after recent rumors — which NASA attempted to dampen last week — that Curiosity had made a huge discovery on Mars.
The observation by Curiosity involved perchlorate, a reactive compound of oxygen and chlorine that had previously been found in the Martian arctic by NASA's Phoenix lander.
Curiosity's SAM instrument uses a tiny oven to cook Mars dirt samples, then study the gases they give off to determine their chemical makeup. Martian soil samples are placed in the device by a scoop on Curiosity's robotic arm.
When Curiosity cooked the perchlorate in its SAM oven, it created chlorinated methane compounds, one-carbon organic material.
"The chlorine is of Martian orgin, but it's possible the carbon may be of Earth origin, carried by Curiosity and detected by SAM's high sensitivity design," NASA officials wrote in a statement.
The new findings by Curiosity came during the rover's study of a patch of windblown Martian dust and sand called "Rocknest." It is a flat stretch of Mars terrain that is still miles away from Curiosity's first destination, rock outcrop called Glenelg at the base of the 3-mile (5 kilometers) Mount Sharp that rises from the center of the rover's landing site — the vast Gale Crater.
While scientists puzzle out the validity of Curiosity's SAM signals, the rover's other instruments have made curious discoveries, as well, mission scientists said.
Curiosity's arm-mounted tools have confirmed that the Martian soil at the Rocknest site is similar in chemical composition and appearance to the dirt seen by NASA's three other rovers: the small Pathfinder, and golf cart-size Spirt and Opportunity rovers.
Photos from the rover's Mars hand Lens Imager, or MAHLI, revealed that the sand drifts at Rocknest have a crusty surface that hides even darker, finer sand below.
Read more at Discovery News
Dec 2, 2012
Breakthrough in the Understanding of Embryonic Stem Cells
A significant breakthrough in the understanding of embryonic stem cells has been made by scientists from the Smurfit Institute of Genetics at Trinity College Dublin. The Trinity research group led by Dr Adrian Bracken and funded by Science Foundation Ireland, has just published their findings in the journal, Nature Structural & Molecular Biology.
The new research describes the process whereby genes that are 'on' in embryonic stem cells are switched 'off'. This process is essential in order to convert embryonic stem cells into different cell types such as neurons, blood or heart cells and therefore represents an important breakthrough in the area of regenerative medicine.
The research encompasses both embryonic stem cell research and epigenetics. Embryonic stem cell research is focused on a particular type of cell that is capable of generating the various tissues in the body; for example, muscle, heart or brain. It is particularly relevant due to its potential for regenerating diseased tissues and organs and for the treatment of a variety of conditions including Parkinson’s disease, diabetes and spinal cord injury
Epigenetics explains how cells in your body with exactly the same genes can be so different functionally. For example, a neuron and a muscle cell look and act very differently, yet contain exactly the same genes. The study of epigenetics has helped us understand that every type of cell has its own unique pattern of genes that are either switched 'on' or 'off'. Different types of cells arise therefore due to these differences.
This new research explores the role of a protein termed a ‘Polycomb group protein’ called PHF19 in mouse embryonic stem cells. Gerard Brien, the lead author on the paper, and PhD student in the laboratory of Dr. Adrian Bracken demonstrated that without PHF19, embryonic stem cells are incapable of generating specialised cells such as those of the heart, lung or brain. He next established that PHF19 plays a critical role in switching the embryonic stem cell genes from an 'on' to an 'off' state during conversion into specialised cells. PHF19 does this by reading an ‘epigenetic mark’ called H3K36me3, which is only found on genes that are 'on'. It then recruits additional ‘Polycomb’ and other proteins, which replace H3K36me3 with another mark, H3K27me3, that is found on genes that are 'off'.
Read more at Science Daily
The new research describes the process whereby genes that are 'on' in embryonic stem cells are switched 'off'. This process is essential in order to convert embryonic stem cells into different cell types such as neurons, blood or heart cells and therefore represents an important breakthrough in the area of regenerative medicine.
The research encompasses both embryonic stem cell research and epigenetics. Embryonic stem cell research is focused on a particular type of cell that is capable of generating the various tissues in the body; for example, muscle, heart or brain. It is particularly relevant due to its potential for regenerating diseased tissues and organs and for the treatment of a variety of conditions including Parkinson’s disease, diabetes and spinal cord injury
Epigenetics explains how cells in your body with exactly the same genes can be so different functionally. For example, a neuron and a muscle cell look and act very differently, yet contain exactly the same genes. The study of epigenetics has helped us understand that every type of cell has its own unique pattern of genes that are either switched 'on' or 'off'. Different types of cells arise therefore due to these differences.
This new research explores the role of a protein termed a ‘Polycomb group protein’ called PHF19 in mouse embryonic stem cells. Gerard Brien, the lead author on the paper, and PhD student in the laboratory of Dr. Adrian Bracken demonstrated that without PHF19, embryonic stem cells are incapable of generating specialised cells such as those of the heart, lung or brain. He next established that PHF19 plays a critical role in switching the embryonic stem cell genes from an 'on' to an 'off' state during conversion into specialised cells. PHF19 does this by reading an ‘epigenetic mark’ called H3K36me3, which is only found on genes that are 'on'. It then recruits additional ‘Polycomb’ and other proteins, which replace H3K36me3 with another mark, H3K27me3, that is found on genes that are 'off'.
Read more at Science Daily
Any Truth Behind Immortal Jellyfish Claim?
If you open a New York Times this weekend, you'll find a story about jellyfish and immortality splashed across the cover of the Sunday magazine.
The 6,500-word narrative is a compelling read, but a critic at the Knight Science Journalism program at MIT urges skepticism.
"...the problem with this story is that much of what is reported is highly improbable, even unbelievable," writes Paul Raeburn. "And the writing is discursive to a fault."
The author, novelist Nathaniel Rich, traveled to Japan to meet a scientist who thinks that an organism known as Turritopsis dohrnii may unlock the secret to human immortality. The tiny jellyfish does a seemingly death-defying trick: After it grows from a polyp to an adult, it reverses the cycle and turns back into a polyp.
But Raeburn points out several red flags, among them: The author contends that the Turritopsis dohrnii is unique in its ability, but then quotes an expert who says that other species do the same thing. Then, another expert is quoted as saying that while the cells are immortal, the organism itself may not be. And it's unclear whether the scientist, Shin Kubota, is clouded by the idea of spiritual immortality.
The bottom line? Here's how Raeburn sums it up:
"It's clear that Rich was seduced by the romance of the story. Kubota is indeed a fascinating character and a prime candidate for a profile. What is missing here is a proper sense of journalistic detachment and skepticism. Kubota seems like a genial fellow, and Rich clearly likes and admires him. There's nothing wrong with that, except that Rich makes the fatal mistake of swallowing everything Kubota tells him. And when Rich briefly quotes critics, he seems to suggest that they dissent only because they do not understand Kubota's work."
So far, there is one correction appended to the online version. Stay tuned.
From Discovery News
The 6,500-word narrative is a compelling read, but a critic at the Knight Science Journalism program at MIT urges skepticism.
"...the problem with this story is that much of what is reported is highly improbable, even unbelievable," writes Paul Raeburn. "And the writing is discursive to a fault."
The author, novelist Nathaniel Rich, traveled to Japan to meet a scientist who thinks that an organism known as Turritopsis dohrnii may unlock the secret to human immortality. The tiny jellyfish does a seemingly death-defying trick: After it grows from a polyp to an adult, it reverses the cycle and turns back into a polyp.
But Raeburn points out several red flags, among them: The author contends that the Turritopsis dohrnii is unique in its ability, but then quotes an expert who says that other species do the same thing. Then, another expert is quoted as saying that while the cells are immortal, the organism itself may not be. And it's unclear whether the scientist, Shin Kubota, is clouded by the idea of spiritual immortality.
The bottom line? Here's how Raeburn sums it up:
"It's clear that Rich was seduced by the romance of the story. Kubota is indeed a fascinating character and a prime candidate for a profile. What is missing here is a proper sense of journalistic detachment and skepticism. Kubota seems like a genial fellow, and Rich clearly likes and admires him. There's nothing wrong with that, except that Rich makes the fatal mistake of swallowing everything Kubota tells him. And when Rich briefly quotes critics, he seems to suggest that they dissent only because they do not understand Kubota's work."
So far, there is one correction appended to the online version. Stay tuned.
From Discovery News
New Clues Date Grand Canyon to Dino Days
The age of the Grand Canyon is a puzzle, because the Colorado River has washed away many of the clues.
So for 150 years, geologists have pondered the processes shaping the canyon, one of the world's great wonders and a living laboratory for understanding Earth history.
The gorge's rugged beauty, with its sheer cliff and steep slopes, looks young. And the general scientific consensus, updated at a 2010 conference, holds that the copper-colored Colorado River carved the Grand Canyon beginning 5 million to 6 million years ago. Many strong lines of evidence support this theory, including a pile of gravel and limestone pancaked with lava at a place called Muddy Creek. This geologic layer cake, at the western mouth of the canyon, locks down the Colorado River from exiting the canyon before 6 million years ago.
However, recent advances in dating techniques have upended the notion of a uniformly young Grand Canyon. The new approach determines when erosion uncovered rocks in the canyon. The big picture: there were two ancestral canyons, one in the west and one in the east. And the western canyon may be as old as 70 million years.
Grand Canyon's ancestors
The latest sally is a study reporting samples from the western Grand Canyon were close to the Earth's surface 70 million years ago. The evidence suggests the western Grand Canyon was cut to within 70 percent of its current depth of 3,200 feet (1,000 meters) long before the Colorado River existed. The results appear today (Nov. 29) in the journal Science.
"Our data suggests that there was in fact a large canyon present for most of the Grand Canyon by about 70 million years ago in its western segment, and that canyon was carved to nearly modern depths," said Rebecca Flowers, lead study author and a geology professor at the University of Colorado, Boulder. "In the eastern canyon, the canyon was higher, and lowered into its modern configuration sometime after 20 million years ago."
This much older western "paleocanyon" was incised by an ancient river flowing west to east. This Cretaceous river carved the western Grand Canyon to within a few hundred meters of its modern depth, and the eastern Grand Canyon to a higher level.
When combined with rock sample ages Flowers collected in the eastern Grand Canyon during this study and in 2008, the overview gives the Grand Canyon a complicated history. However, the research can fit into the constraints presented by the Muddy Creek barrier and other evidence supporting a young canyon, Flowers told OurAmazingPlanet.
"The presence of the [Muddy Creek] detritus represents the integration of the river system," Flowers said. That is, the Muddy Creek simply represents the Colorado River appropriating the paleocanyons and created a single drainage 6 million years ago.
Two canyons?
Geologist Richard Young, who has studied the Grand Canyon for nearly 50 years, said scientists have considered the idea of two Grand Canyon precursors — one west, one east — since the research community's first symposium in 1964.
"We agreed that there were two canyons, one in the west and in the east, we don't disagree on that," he said. The problem is that Dr. Flowers wants to make the western canyon very old, Young told OurAmazingPlanet.
"It really looks like they're onto something, but it's hard to make sense out of it," said Young, a professor at the State University of New York in Geneseo. "It's really good work and it's really interesting, so obviously there's something we're missing in the story. I'm sure we're going to be talking about it forever," he said.
Recent work by geologist Karl Karlstrom supports the idea for a paleocanyon in the east. "We showed very conclusively that there was a paleocanyon in the eastern Grand Canyon that was carved between 25 and 15 million years ago," said Karlstrom, a professor at the University of New Mexico in Albuquerque.
But Karlstrom is a strong advocate for a Grand Canyon quickly carved by the Colorado River starting 6 million years ago, not older rivers coming from the west. The western Grand Canyon region was cut across nearly at right angles by one or more paleocanyons with rivers that flowed north around 70 million years ago, but these paleorivers did not follow the modern course of Grand Canyon, Karlstrom said.
"The best answer is that Grand Canyon was carved by the west-flowing Colorado River in the last 5 to 6 million years and that earlier paleocanyons were likely re-used and deepened once the river found its present path," he said.
Southwest during the end of the dinosaurs
The American Southwest had a radically different appearance 70 million years ago. Most of the region's famed dinosaur fossils come from the Jurassic, and the canyon-cutting identified by Flowers and colleague Ken Farley of Caltech began in the Late Cretaceous.
Seen from the air, the flat Colorado plateau might be recognizable, but the rainbow-hued pillars and monuments of national parks such as Arches, Zion and Bryce had yet to take shape. Close to the west rose a volcanic arc similar to today's Andes — the precursor to California's Sierra Nevada Mountains. A wrinkled belt called the Sevier mountains was northwest of the plateau. To the east was the Western Interior Seaway. Rivers flowed out of mountains generally heading northeast into the ocean.
Read more at Discovery News
So for 150 years, geologists have pondered the processes shaping the canyon, one of the world's great wonders and a living laboratory for understanding Earth history.
The gorge's rugged beauty, with its sheer cliff and steep slopes, looks young. And the general scientific consensus, updated at a 2010 conference, holds that the copper-colored Colorado River carved the Grand Canyon beginning 5 million to 6 million years ago. Many strong lines of evidence support this theory, including a pile of gravel and limestone pancaked with lava at a place called Muddy Creek. This geologic layer cake, at the western mouth of the canyon, locks down the Colorado River from exiting the canyon before 6 million years ago.
However, recent advances in dating techniques have upended the notion of a uniformly young Grand Canyon. The new approach determines when erosion uncovered rocks in the canyon. The big picture: there were two ancestral canyons, one in the west and one in the east. And the western canyon may be as old as 70 million years.
Grand Canyon's ancestors
The latest sally is a study reporting samples from the western Grand Canyon were close to the Earth's surface 70 million years ago. The evidence suggests the western Grand Canyon was cut to within 70 percent of its current depth of 3,200 feet (1,000 meters) long before the Colorado River existed. The results appear today (Nov. 29) in the journal Science.
"Our data suggests that there was in fact a large canyon present for most of the Grand Canyon by about 70 million years ago in its western segment, and that canyon was carved to nearly modern depths," said Rebecca Flowers, lead study author and a geology professor at the University of Colorado, Boulder. "In the eastern canyon, the canyon was higher, and lowered into its modern configuration sometime after 20 million years ago."
This much older western "paleocanyon" was incised by an ancient river flowing west to east. This Cretaceous river carved the western Grand Canyon to within a few hundred meters of its modern depth, and the eastern Grand Canyon to a higher level.
When combined with rock sample ages Flowers collected in the eastern Grand Canyon during this study and in 2008, the overview gives the Grand Canyon a complicated history. However, the research can fit into the constraints presented by the Muddy Creek barrier and other evidence supporting a young canyon, Flowers told OurAmazingPlanet.
"The presence of the [Muddy Creek] detritus represents the integration of the river system," Flowers said. That is, the Muddy Creek simply represents the Colorado River appropriating the paleocanyons and created a single drainage 6 million years ago.
Two canyons?
Geologist Richard Young, who has studied the Grand Canyon for nearly 50 years, said scientists have considered the idea of two Grand Canyon precursors — one west, one east — since the research community's first symposium in 1964.
"We agreed that there were two canyons, one in the west and in the east, we don't disagree on that," he said. The problem is that Dr. Flowers wants to make the western canyon very old, Young told OurAmazingPlanet.
"It really looks like they're onto something, but it's hard to make sense out of it," said Young, a professor at the State University of New York in Geneseo. "It's really good work and it's really interesting, so obviously there's something we're missing in the story. I'm sure we're going to be talking about it forever," he said.
Recent work by geologist Karl Karlstrom supports the idea for a paleocanyon in the east. "We showed very conclusively that there was a paleocanyon in the eastern Grand Canyon that was carved between 25 and 15 million years ago," said Karlstrom, a professor at the University of New Mexico in Albuquerque.
But Karlstrom is a strong advocate for a Grand Canyon quickly carved by the Colorado River starting 6 million years ago, not older rivers coming from the west. The western Grand Canyon region was cut across nearly at right angles by one or more paleocanyons with rivers that flowed north around 70 million years ago, but these paleorivers did not follow the modern course of Grand Canyon, Karlstrom said.
"The best answer is that Grand Canyon was carved by the west-flowing Colorado River in the last 5 to 6 million years and that earlier paleocanyons were likely re-used and deepened once the river found its present path," he said.
Southwest during the end of the dinosaurs
The American Southwest had a radically different appearance 70 million years ago. Most of the region's famed dinosaur fossils come from the Jurassic, and the canyon-cutting identified by Flowers and colleague Ken Farley of Caltech began in the Late Cretaceous.
Seen from the air, the flat Colorado plateau might be recognizable, but the rainbow-hued pillars and monuments of national parks such as Arches, Zion and Bryce had yet to take shape. Close to the west rose a volcanic arc similar to today's Andes — the precursor to California's Sierra Nevada Mountains. A wrinkled belt called the Sevier mountains was northwest of the plateau. To the east was the Western Interior Seaway. Rivers flowed out of mountains generally heading northeast into the ocean.
Read more at Discovery News
Cave Structure Tells Tale of 13,000 Winters
Scientists have found a stalagmite in an Oregon cave that tells the story of thousands of winters in the Pacific Northwest.
"Most other ways of estimating past climate, like tree-ring data, only tell us about summers, when plants are growing," Oxford University researcher Vasile Ersek said in a statement. But understanding ancient winters is also important for regions like western North America, where chilly conditions are critical for determining water resources.
For their study, Ersek and his colleagues examined a cave formation called a stalagmite that started forming 13,000 years ago in a cavern in what is now Oregon Caves National Monument. During the region's damp winters, water from the ground seeped through the cave's ceiling and trickled onto the floor, with the drips slowly forming the stalagmite over time.
The ratio of certain oxygen and carbon isotopes (atoms of the same element with a different number of neutrons) in these deposits provides information on ancient climate.
The researchers' measurements of these chemical components showed that the Pacific Northwest of recent prehistory saw rapid shifts between dry and warm, and wet and cold periods, similar to the currently observed Pacific Decadal Oscillation (PDO) — a pattern of climate variability that switches between negative and positive every couple of decades. In a positive, or warm, phase, the surface waters of the west Pacific become cool and part of the eastern ocean warms, while the opposite occurs during a negative, or cool, phase.
"Whilst we can't directly relate these changes to the Pacific Decadal Oscillation, the mechanisms involved do look similar," Ersek said in a statement from Oxford. "Getting a long-term perspective on these sorts of natural climate variations may help us to understand the potential for future loss of winter snow cover along the West Coast, as well as what's happening out in the Pacific to influence other cyclical climate events such as El Niño."
Read more at Discovery News
"Most other ways of estimating past climate, like tree-ring data, only tell us about summers, when plants are growing," Oxford University researcher Vasile Ersek said in a statement. But understanding ancient winters is also important for regions like western North America, where chilly conditions are critical for determining water resources.
For their study, Ersek and his colleagues examined a cave formation called a stalagmite that started forming 13,000 years ago in a cavern in what is now Oregon Caves National Monument. During the region's damp winters, water from the ground seeped through the cave's ceiling and trickled onto the floor, with the drips slowly forming the stalagmite over time.
The ratio of certain oxygen and carbon isotopes (atoms of the same element with a different number of neutrons) in these deposits provides information on ancient climate.
The researchers' measurements of these chemical components showed that the Pacific Northwest of recent prehistory saw rapid shifts between dry and warm, and wet and cold periods, similar to the currently observed Pacific Decadal Oscillation (PDO) — a pattern of climate variability that switches between negative and positive every couple of decades. In a positive, or warm, phase, the surface waters of the west Pacific become cool and part of the eastern ocean warms, while the opposite occurs during a negative, or cool, phase.
"Whilst we can't directly relate these changes to the Pacific Decadal Oscillation, the mechanisms involved do look similar," Ersek said in a statement from Oxford. "Getting a long-term perspective on these sorts of natural climate variations may help us to understand the potential for future loss of winter snow cover along the West Coast, as well as what's happening out in the Pacific to influence other cyclical climate events such as El Niño."
Read more at Discovery News
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Archeology,
Earth,
Geology,
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