Jul 10, 2012

Rare Glimpse Into the Origin of Species

A new species of monkey flower, created by the union of two foreign plant species, has been discovered on the bank of a stream in Scotland. Genetic changes in this attractive yellow-flowered hybrid have allowed it to overcome infertility and made it a rare example of a brand new species that has originated in the wild in the last 150 years. Thousands of wild species and some crops are thought to have originated in this way, yet only a handful of examples exist where this type of species formation has occurred in recent history.

The ancestors of the new plant were brought from the Americas as botanical curiosities in the 1800s and were quickly adopted by Victorian gardeners. Soon after their arrival, they escaped the confines of British gardens and can now be found growing in the wild, along the banks of rivers and streams. Reproduction between these species produces hybrids that are now widespread in Britain. Yet, genetic differences between the two parents mean that the hybrids are infertile and cannot go beyond the first generation.

Dr Mario Vallejo-Marin, a plant evolutionary biologist at the University of Stirling, has documented the first examples of hybrid monkey flowers that have overcome these genetic barriers and show fully restored fertility. This fertile hybrid derived from 'immigrant' parents represents a new species, native to Scotland. Dr Vallejo-Marin has chosen to name this species Mimulus peregrinus, which translates as 'the wanderer'. The species is described in the open access journal PhytoKeys.

'The two American monkey flowers are unable to produce fertile hybrids due to differences in the amount of DNA present in each species, the equivalent of getting a sterile mule from crossing a horse and a donkey', said Dr. Vallejo-Marin. 'However, in rare cases, duplication of the entire hybrid DNA, known as polyploidization, can balance the amount of DNA and restore fertility. Our studies suggest that this is what has happened here.'

Read more at Science Daily

Hubble Unmasks Ghost Galaxies

Astronomers have used the NASA/ESA Hubble Space Telescope to study some of the smallest and faintest galaxies in our cosmic neighbourhood. These galaxies are fossils of the early Universe: they have barely changed for 13 billion years. The discovery could help explain the so-called "missing satellite" problem, where only a handful of satellite galaxies have been found around the Milky Way, against the thousands that are predicted by theories.

Astronomers have puzzled over why some extremely faint dwarf galaxies spotted in our Milky Way galaxy's backyard contain so few stars. The galaxies are thought to be some of the tiniest, oldest, and most pristine galaxies in the Universe. They have been discovered over the past decade by astronomers using automated computer techniques to search through the images of the Sloan Digital Sky Survey. But an international team of astronomers needed the NASA/ESA Hubble Space Telescope to help solve the mystery of why these galaxies are starved of stars, and why so few of them have been found.

Hubble views of three of these small galaxies, the Hercules, Leo IV and Ursa Major dwarf galaxies, reveal that they all started forming stars more than 13 billion years ago -- and then abruptly stopped -- all in the first billion years after the Universe was born in the Big Bang. In fact, the extreme age of their stars is similar to Messier 92, the oldest known globular cluster [1] in the Milky Way.

"These galaxies are all ancient and they're all the same age, so you know something came down like a guillotine and turned off the star formation at the same time in these galaxies," said Tom Brown of the Space Telescope Science Institute in Baltimore, USA, the study's leader. "The most likely explanation is a process called reionisation."

The relic galaxies are evidence for a transitional phase in the early Universe that shut down star-making factories in tiny galaxies. This phase seems to coincide with the time when the first stars burned off a fog of cold hydrogen, a process called reionisation. In this period, which began in the first billion years after the Big Bang, radiation from the first stars knocked electrons off primeval hydrogen atoms, ionising the Universe's cool hydrogen gas.

The same radiation that sparked universal reionisation also appears to have squelched star-making activities in dwarf galaxies, such as those in Brown's study. The small irregular galaxies were born about 100 million years before reionisation began and had just started to churn out stars at that time. Roughly 2000 light-years wide, these galaxies are the lightweight cousins of the more luminous and higher-mass star-making dwarf galaxies near our Milky Way. Unlike their higher-mass relatives, the puny galaxies were not massive enough to shield themselves from the harsh ultraviolet light. What little gas they had was stripped away as the flood of ultraviolet light rushed through them. Their gas supply depleted, the galaxies could not make new stars.

The discovery could help explain the so-called "missing satellite problem," where only a few dozen dwarf galaxies have been observed around the Milky Way while the computer simulations predict that thousands should exist. One possible explanation for the low number discovered to date is that there has been very little, or even no star formation in the smallest of these dwarf galaxies, leaving them virtually invisible.

The Sloan survey recently uncovered more than a dozen of these galaxies in our cosmic neighbourhood. These have very few stars -- only a few hundred or thousand -- but a great deal of dark matter, the underlying scaffolding upon which galaxies are built. Normal dwarf galaxies near the Milky Way contain 10 times more dark matter than the ordinary matter that makes up gas and stars, while in these so-called ultra-faint dwarf galaxies, dark matter outweighs ordinary matter by at least a factor of 100. Astronomers think the rest of the sky should contain dozens more of these ultra-faint dwarf galaxies with few stars, and the evidence for squelched star formation in the smallest of these dwarfs suggests that there may be still thousands more with essentially no stars at all.

Read more at Science Daily

Why Sunburn Hurts

It's no secret that too much time in the sun causes pain, redness and a strong desire for aloe vera lotion. Now, researchers know why.

The ultraviolet B (UVB) wavelength of light damages skin cells' RNA molecules, new research finds. RNA, or ribonucleic acid, is part of the genetic machinery of the cell, encoding information to turn genetic instructions in DNA into proteins.

The RNA damaged by UVB light is of a sort that doesn't code for proteins, researchers reported online July 8 in the journal Nature Medicine. But when sun-damaged cells release this damaged non-coding micro-RNA, it provokes neighboring cells to flood the skin with inflammatory molecules, creating a chain reaction that ends with sunburn. In the long run, cumulative damage can raise the risk of skin cancer. In the short run, this process is how the skin heals from the burn.

"The inflammatory response is important to start the process of healing after cell death," study leader Richard Gallo of the University of California, San Diego School of Medicine said in a statement.

Though researchers have long known about some of the molecular effects of too much time tanning, this is the first time they've identified step one in the process of damage. Now that the cause has been identified, the researchers hope to find some way of stopping the process — for sun-sensitive patients, if not for ordinary sun-bathers.

"For example, diseases like psoriasis are treated by UV light, but a big side effect is that this treatment increases the risk of skin cancer," Gallo said, referring to a skin condition that causes flaking and redness. "Our discovery suggests a way to get the beneficial effects of UV therapy without actually exposing our patients to the harmful UV light. Also, some people have excess sensitivity to UV light, patients with lupus, for example. We are exploring if we can help them by blocking the pathway we discovered."

The researches made the discovery by exposing human skin cells to UVB light and following up with experiments in mice. Specific genes in mice can determine how likely they are to burn in the sun, Gallo said.

Read more at Discovery News

Ancient 'New York City' of Canada Discovered

Today New York City is the Big Apple of the Northeast but new research reveals that 500 years ago, at a time when Europeans were just beginning to visit the New World, a settlement on the north shore of Lake Ontario, in Canada, was the biggest, most complex, cosmopolitan place in the region.

Occupied between roughly A.D. 1500 and 1530, the so-called Mantle site was settled by the Wendat (Huron). Excavations at the site, between 2003 and 2005, have uncovered its 98 longhouses, a palisade of three rows (a fence made of heavy wooden stakes and used for defense) and about 200,000 artifacts. Dozens of examples of art have been unearthed showing haunting human faces and depictions of animals, with analysis ongoing.

Now, a scholarly book detailing the discoveries is being prepared and a documentary about the site called "Curse of the Axe" aired this week on the History Channel in Canada.

"This is an Indiana Jones moment, this is huge," said Ron Williamson, an archaeologist who led dig efforts at the site, in the documentary shown in a premiere at the Royal Ontario Museum. "It just seems to be a game-changer in every way."

Williamson is the founder of Archaeological Services Inc., a Canadian cultural resource management firm that excavated the site.

"It's the largest, most complex, cosmopolitan village of its time," said Williamson, also of the University of Toronto, in an interview with LiveScience.  "All of the archaeologists, basically, when they see Mantle, they're just utterly stunned."

The Mantle people

Scientists estimate between 1,500 and 1,800 individuals inhabited the site, whose fields encompassed a Manhattan-size area. To clothe themselves they would have needed 7,000 deer hides annually, something that would have required hunting about 26 miles (40 km) in every direction from the site, Williamson said.

"When you think about a site like Mantle, 2,000 people, massive stockade around a community, a better analogy is that of a medieval town," Jennifer Birch, a post-doctoral researcher at the University of Georgia, said in the documentary. "While the cultures are very different, the societal form really isn't."

Despite its massive size, the site remained hidden for hundreds of years, likely escaping detection because its longhouses were primarily made of wood, which doesn't preserve well.

Not all of the 98 longhouses were in use at the same time, with more recent ones having been built on top of the older longhouses, as buildings are today.  At one point 55 longhouses were in use at once.

Charred wood found in one of the post moulds suggested that when one of the longhouses burnt down the rest of the settlement was saved. Williamson said that this is remarkable considering the longhouses were made of wood, which was very flammable, and close together. "Somehow their 'fire department' did that."

Enemies become friends

Another curious discovery at Mantle is its apparently cosmopolitan nature. The art and pottery at the site show influences from all five nations of the Iroquois to the south in New York State, suggesting extensive contacts and trade.

For instance, among Mantle's discoveries are the earliest European goods ever found in the Great Lakes region of North America, predating the arrival of the first known European explorers by a century. They consist of two European copper beads and a wrought iron object, believed to be part of an ax, which was carefully buried near the center of the settlement.

A maker's mark on the wrought iron object was traced to northern Spain, and the fact that it was made of wrought iron suggests a 16th-century origin. In fact, in the early 16th century Basque fisherman and whalers sailed to the waters off Newfoundland and Labrador. It's believed that it would have been acquired by the aboriginal people there and exchanged up the St. Lawrence River until eventually reaching Mantle.

The people of Mantle, it seems, were on trading relations with the Iroquois of the St. Lawrence.

"Historically, we know that the Huron and the Iroquois were not only at odds, they were mortal enemies," Williamson said in the documentary.

In the period before Mantle there is evidence of widespread warfare throughout southern Ontario and New York as well as parts of Michigan and Quebec, a period known as "the dark times." Human remains from that period show evidence of scalping and torture.

Mantle, with its large size and palisade defense, may have discouraged this type of warfare, making an attack risky. Other settlements in southwest Ontario were getting larger and sites in New York were clustering together, suggesting that they too were becoming harder to attack.

Birch compares the situation at Mantle and other sites to what happened after World War II, with the formation of the United Nations and NATO, institutions that discouraged warfare, allowing for trade and cultural interaction.

Williamson noted that, sadly, with the arrival of Europeans, this peace did not last, with warfare intensifying in the 17th century. "When Europeans arrive the whole thing is re-fired over economic reasons related to the fur trade," he said in the interview.

Read more at Discovery News

Jul 9, 2012

'Frankenstein' Mummies Are a Mix of Corpses

Mummies found off the coast of Scotland are Frankenstein-like composites of several corpses, researchers say.

This mixing of remains was perhaps designed to combine different ancestries into a single lineage, archaeologists speculated.

The bodies were first unearthed in 2001 during excavations beneath the foundations of an approximately 3,000-year-old house on South Uist, an island in the Outer Hebrides off the west coast of Scotland. The building was one of three roundhouses at Cladh Hallan, a prehistoric village named after a nearby modern graveyard. The site was once populated in the Bronze Age from 2200 B.C. to 800 B.C. — scientists were digging here to learn more about this era in Britain, where little was known until recently.

The researchers had found what were apparently the remains of a teenage girl and a 3-year-old child at the site. However, two other bodies looked especially strange — those of a man and a woman found in tight fetal positions as if they had been tightly wrapped up, reminiscent of "mummy bundles" seen in South America and other parts of the world. These bodies were apparently mummified on purpose, the first evidence of deliberate mummification in the ancient Old World outside of Egypt.

Evidence for mummy mix-ups

Evidence of this mummification lies in how all the bones in both these bodies were still "articulated" or in the same positions as they were in life, revealing that sinew and perhaps skin were still holding them together when they were buried. Carbon dating these remains and their surroundings revealed these bodies were buried up to 600 years after death — to keep bodies from rotting to pieces after such a long time, they must have been intentionally preserved, unlike the bodies of animals also buried at the site, which had been left to decay.

Mineral alterations of the outer layer of the bones suggest they were entombed in acidic surroundings, such as those found in nearby peat bogs. Exposures to such bogs for a year or so would have mummified them, stopping microbes from decomposing the bodies by essentially tanning them in much the same way that animal skin is turned into leather.

Ancient writings suggest that embalming was practiced in prehistoric Europe, not just in Egypt. For instance, ancient Greek philosopher Poseidonius, writing in about 100 B.C., "visited Gaul and recorded that the Celts there embalmed the heads of their victims in cedar oil and kept them in chests," said researcher Mike Parker-Pearson, an archaeologist at the University of Sheffield in England.

Bizarrely, the man's remains were composed of bones from three different people, possessing the torso and limbs of one man, the skull and neck of another, and the lower jaw from a third, possibly a woman.

The researchers made this discovery of his Frankenstein-like nature by analyzing his skeleton — for instance, evidence of arthritis was seen on the vertebrae of the neck, but not on the rest of the spine, revealing these parts came from different bodies. Also, the lower jaw had all its teeth, whereas those of the upper jaw were entirely missing, and the condition of the lower jaw's teeth revealed they once interacted with a full set of teeth in his upper jaw, showing they originally belonged to another man.

To see if the woman's skeleton was also a composite, the researchers analyzed ancient DNA from the skull, lower jaw, right upper arm and right thighbone. This revealed that the lower jaw, arm bone and thighbone all came from different people. Data from the skull was inconclusive. (Oddly, the upper two teeth next to her front teeth had been removed and placed in each hand.)

The first composite was apparently assembled between 1260 B.C. and 1440 B.C., while the second composite was assembled between 1130 B.C. and 1310 B.C. "There is overlap, but the statistical probability is that they were assembled at different times," Parker-Pearson said.

Although one Frankenstein-like mix-up of body parts might be an accident, "the second instance makes this unlikely," Parker-Pearson said.

Mummification apparently took off in Britain about 1500 B.C. "at a time when land ownership — communal rather than private, most likely — was being marked by the construction of large-scale field systems," Parker-Pearson told LiveScience. "Rights to land would have depended on ancestral claims, so perhaps having the ancestors around 'in the flesh' was their prehistoric equivalent of a legal document."

"Merging different body parts of ancestors into a single person could represent the merging of different families and their lines of descent," Parker-Pearson said. "Perhaps this was a prelude to building the row of houses in which numerous different families are likely to have lived."

Mummies? Britain?

When the bones were first discovered, Parker-Pearson admitted, "some archaeologists were rightly skeptical," as mummification in the British Bronze Age was pretty much unheard of.

Even Parker-Pearson would've been skeptical of the finding, had he not studied the bones. "But since then, we have applied a battery of scientific methods, of which the ancient DNA analysis is the latest," he said. "Together with archaeological evidence from excavation, these analytical results make a fairly unassailable case for mummification and recombination."

"I don't think it implies any links with ancient Egypt or other distant civilizations at all," Parker-Pearson said about these findings. "Mummification is simple enough to do in your own kitchen, and has been surprisingly widespread among small-scale, traditional societies throughout the world in recent centuries."

Read more at Discovery News

Animals Navigate With Magnetic Cells

Salmon, turtles and many birds migrate up to thousands of miles at a time, presumably by sensing the Earth's magnetic field. Now, scientists have identified cells in the nose of trout that respond to magnetism, offering a biological explanation for how animals orient themselves and find their way, even when it's dark or foggy.

The discovery -- and particularly the new method that enabled it -- opens up avenues for all sorts of futuristic applications, including miniaturized GPS systems or gene therapies that would restore sight, hearing or smell to people who have lost those senses.

The ability to detect magnetic-sensitive cells in the lab could also help answer questions about whether people are at risk from magnetic fields produced by power lines and other equipment.

"The key point is really the method we established. Some people call it a game-changer," said Michael Winklhofer, a biogeophysicist at the University of Munich. "Previously, we didn't have a tool to collect these cells. Now, we can do some serious cell biology on them."

"There's no doubt that many animals have a magnetic sense, particularly migratory birds and fish," he added. "But the problem is, we still don't know how that works."

Winklhofer and colleagues chose to study the olfactory tissues of trout based on decade-old research, which showed that magnetic fields affected the electrical activity of nerves that carried information from the fishes' noses. Instead of grinding up the tissues for analysis, as older methods tended to do, the researchers gently isolated whole cells from the tissues and put them into petri dishes.

When the team applied rotating magnetic fields to those dishes, about one out of every 10,000 cells spun with the same frequency as the fields, the researchers report today in the Proceedings of the National Academy of Sciences. Illuminated by the light of the microscope, structures inside of these cells also shone brilliantly, making them easy to detect.

A closer look revealed crystals attached to inside the cell membranes that contained what appeared to be magnetite, an iron-rich magnetic material. Scientists don't yet know how these structures work, but Winklhofer suspects that they excite membranes inside neurons and trigger nerve impulses that send direction-related information to the brain.

Based on the abundance of magnetic cells in the samples, Winklhofer estimated that each fish had a total of between 10 and 100 of these cells in its nose. As expected, there were no magnetic cells in the animals' muscle tissue. But in work yet to be published, his group detected even more magnetic cells in the trout's lateral line, a sensory organ in fish that detects vibrations.

Because magnetic fields penetrate the entire body, magnetic-sensing cells could be sporadically spread throughout in other body parts, too, which would make sense. If the cells were too close together, they would begin to sense each other's magnetic fields instead of the larger fields around the planet. Like needles in a haystack, though, magnetic cells can be difficult to find, which is what makes the new method so valuable.

The new technique also makes it possible to look for magnetic cells in animals that don't necessarily use a sense of magnetism but may have retained the cells even as evolution made them obsolete. In a 2008 study, for example, German researchers analyzed Google Earth images and saw that cows and deer tended to stand facing magnetic north or south.

Some recent research suggests that even people might harbor magnetic cells that linger from our ancestral hunter-gatherer days. If so, magnetic fields from power lines could be causing stress inside of our cells, leading to unknown health effects.

Researchers also hope to identify the genes and proteins responsible for producing magnetic-sensing cells, which would go a long way toward explaining how migrating animals accomplish such amazing feats. These discoveries would also pave the way for applications, such as tiny GPS systems or even novel strategies for healing blindness and other sensory problems in people.

Read more at Discovery News

Space Worms Live Long and Prosper

A microscopic worm used in experiments on the space station not only seems to enjoy living in a microgravity environment, it also appears to get a lifespan boost.

This intriguing discovery was made by University of Nottingham scientists who have flown experiments carrying thousands of tiny Caenorhabditis elegans (C. elegans) to low-Earth orbit over the years. But why are these little worms so special?

C. elegans may be microscopic, but they were the first multi-cellular organism to have their genetic structure completely mapped. These little guys possess 20,000 genes that perform similar functions as equivalent genes in humans. Of particular interest are the 2,000 genes that have a role in promoting muscle function. As any long-duration astronaut can attest, one of the biggest challenges facing mankind's future in space is muscle atrophy.

Understanding how C. elegans function in space is therefore of huge scientific value not only for tiny worm enthusiasts, but for the manned exploration -- and colonization -- of space.

In 2011, Discovery News reported on some results to come from the C. elegans experiments. Nathaniel Szewczyk, of the Division of Clinical Physiology at the University of Nottingham, discussed the worms' microgravity reproduction habits and, as it turns out, C. elegans prospered just fine. Over three months, Szewczyk's team were able to observe the space worms flourish over twelve generations.

And now, in results published on July 5 in the online journal Scientific Reports, it appears that C. elegans not only adapted to microgravity conditions, their lifespans also received a boost when compared with their terrestrial counterparts.

"We identified seven genes, which were down-regulated in space and whose inactivation extended lifespan under laboratory conditions," Szewczyk said in a press release. This basically means that seven C. elegans genes usually associated with muscle aging were suppressed when the worms were exposed to a microgravity environment. Also, it appears spaceflight suppresses the accumulation of toxic proteins that normally gets stored inside aging muscle.

But the biological mechanisms behind this anti-aging effect are a bit of a mystery.

"It would appear that these genes are involved in how the worm senses the environment and signals changes in metabolism in order to adapt to the environment," added Szewczyk. "For example, one of the genes we have identified encodes insulin which, because of diabetes, is well known to be associated with metabolic control. In worms, flies, and mice insulin is also associated with modulation of lifespan."

Read more at Discovery News

Earth's Biggest Unanswered Questions

So, what are today’s biggest unanswered questions in Earth science?

Kathyrn Hansen, associate editor of EARTH magazine, recently posed the question to a variety of experts ranging from paleontologists and geologists to atmospheric and planetary scientists. From Hansen's compilation, here are Three Big Unanswered Questions that caught my eye:

BIG UNANSWERED QUESTION #1:

Where are all the big magma chambers that could produce super-eruptions?

Geologists can tell us where supervolcanoes have exploded in the past, but so far none of those old scars seem to have much liquid magma brewing beneath them. Why haven’t we found any big magma chambers yet?

John Eichelberger, a volcanologist with the U.S. Geological Survey, offers several possibilities. Maybe the old supervolcanoes already spent themselves and the magma chambers are empty. Maybe we haven't looked in the right place or our techniques aren’t yet good enough. Or, as geophysicists reported recently, maybe supervolcanoes develop very fast and erupt quickly:

True supervolcano eruptions, ones that spew lava and ash on the order of 1,000 cubic kilometers or more, are incredibly rare; on average, only about one super-eruption occurs every 100,000 years. So we humans really aren’t at much risk. But just imagine…what if? Simply put, the consequences would be apocalyptic.

As Eichelberger notes: “Danger, however unlikely, is fascinating.”

BIG UNANSWERED QUESTION #2:

How stable is the West Antarctic Ice Sheet and what does it mean for global sea level?

Supervolcanoes may not be much risk for those of us living on Earth today, but the devastating consequences of rising sea level are already very real:

With so much of the world's population living near the coasts, scientists would really like to be able to make predictions precise enough for people to plan how to handle the loss of land and threats to coastal communities that are expected by the end of this century.

But so far, they can’t. Bummer.

BIG UNANSWERED QUESTION #3:

So we know a lot about dinosaur fossils, but what about dinosaur biology?

In the case of dinosaurs, it’s a good thing scientists don’t have all the answers.

“Answers to all of the questions about dinosaurs might well take away the very mystery that surrounds them, and it’s the mystery that charges children's imaginations,” notes Jack Horner, a paleontologist at Montana State University.

For all that paleontologists know about the size and shape of dinosaurs, they still know surprisingly little about their biology. In Horner’s opinion, figuring out how gigantic sauropods could be so wildly successful is the key to understanding dinosaurs as living animals.

Read more at Discovery News

Jul 8, 2012

Patients Trust Doctors but Consult the Internet

Patients look up their illnesses online to become better informed and prepared to play an active role in their care -- not because they mistrust their doctors, a new University of California, Davis, study suggests.

The study surveyed more than 500 people who were members of online support groups and had scheduled appointments with a physician.

"We found that mistrust was not a significant predictor of people going online for health information prior to their visit," said Xinyi Hu, who co-authored the study as part of her master's thesis in communication. "This was somewhat surprising and suggests that doctors need not be defensive when their patients come to their appointments armed with information taken from the Internet."

With faculty co-authors at UC Davis and the University of Southern California, Hu examined how the study subjects made use of support groups, other Internet resources, and offline sources of information, including traditional media and social relations, before their medical appointments.

The study found no evidence that the users of online health information had less trust in their doctors than patients who did not seek information through the Internet.

"The Internet has become a mainstream source of information about health and other issues," Hu noted. "Many people go online to get information when they anticipate a challenge in their life. It makes sense that they would do the same when dealing with a health issue."

Although physician mistrust did not predict reliance on the Internet prior to patients' medical visits, several other factors did. For example, people were more likely to seek information online when their health situation was distressful or when they felt they had some level of personal control over their illness. Online information-seeking was also higher among patients who believed that their medical condition was likely to persist.

The study also found that Internet health information did not replace more traditional sources of information. Instead, patients used the Internet to supplement offline sources, such as friends, health news reports and reference books.

"With the growth of online support groups, physicians need to be aware that many of their patients will be joining and interacting with these groups. These patients tend to be very active health-information seekers, making use of both traditional and new media," the study said.

Almost 70 percent of the study subjects reported they were planning to ask their doctor questions about the information they found, and about 40 percent said they had printed out information to take with them to discuss with their doctors. More than 50 percent of subjects said they intended to make at least one request of their doctor on the basis of Internet information.

"As a practicing physician, these results provide some degree of reassurance," said co-author Richard L. Kravitz, a UC Davis Health System professor of internal medicine and study co-author. "The results mean that patients are not turning to the Internet out of mistrust; more likely, Internet users are curious information seekers who are just trying to learn as much as they can before their visit."

Online support groups provide online virtual meeting places for sharing information and social support. In February 2011, there were more than 12,000 groups listed in the support category of Yahoo! Groups Health and Wellness directory. Even so, other studies suggest that only 9 percent of Americans and 37 percent of patients with chronic disease have participated in online support groups. The majority of subjects assessed their own health as fair or poor.

Read more at Science Daily

What the Discovery of the Higgs Means for Scientists

Stephen Wolfram’s diverse areas of research include mathematics, physics, and computing. Though his early career was focused on particle physics, he went on to create the widely used computer algebra system Mathematica and, later, the search engine Wolfram Alpha. He is author of A New Kind of Science — a study of simple computational systems such as cellular automata — and current CEO of Wolfram Research.

The announcement early yesterday morning of experimental evidence for what’s presumably the Higgs particle brings a certain closure to a story I’ve watched (and sometimes been a part of) for nearly 40 years. In some ways I felt like a teenager again. Hearing about a new particle being discovered. And asking the same questions I would have asked at age 15. “What’s its mass?” “What decay channel?” “What total width?” “How many sigma?” “How many events?”

When I was a teenager in the 1970s, particle physics was my great interest. It felt like I had a personal connection to all those kinds of particles that were listed in the little book of particle properties I used to carry around with me. The pions and kaons and lambda particles and f mesons and so on. At some level, though, the whole picture was a mess. A hundred kinds of particles, with all sorts of detailed properties and relations. But there were theories. The quark model. Regge theory. Gauge theories. S-matrix theory. It wasn’t clear what theory was correct. Some theories seemed shallow and utilitarian; others seemed deep and philosophical. Some were clean but boring. Some seemed contrived. Some were mathematically sophisticated and elegant; others were not.

By the mid-1970s, though, those in the know had pretty much settled on what became the Standard Model. In a sense it was the most vanilla of the choices. It seemed a little contrived, but not very. It involved some somewhat sophisticated mathematics, but not the most elegant or deep mathematics. But it did have at least one notable feature: of all the candidate theories, it was the one that most extensively allowed explicit calculations to be made. They weren’t easy calculations—and in fact it was doing those calculations that got me started having computers to do calculations, and set me on the path that eventually led to Mathematica. But at the time I think the very difficulty of the calculations seemed to me and everyone else to make the theory more satisfying to work with, and more likely to be meaningful.

At the least in the early years there were still surprises, though. In November 1974 there was the announcement of the J/psi particle. And one asked the same questions as today, starting with “What’s the mass?” (That particle’s was 3.1 GeV; today’s is 126 GeV.) But unlike with the Higgs particle, to almost everyone the J/psi was completely unexpected. At first it wasn’t at all clear what it could be. Was it evidence of something truly fundamental and exciting? Or was it in a sense just a repeat of things that had been seen before?

My own very first published paper (feverishly worked on over Christmas 1974 soon after I turned 15) speculated that it and some related phenomena might be something exciting: a sign of substructure in the electron. But however nice and interesting a theory may be, nature doesn’t have to follow it. And in this case it didn’t. And instead the phenomena that had been seen turned out to have a more mundane explanation: they were signs of an additional (4th) kind of quark (the c or charm quark).

In the next few years, more surprises followed. Mounting evidence showed that there was a heavier analog of the electron and muon—the tau lepton. Then in July 1977 there was another “sudden discovery”, made at Fermilab: this time of a particle based on the b quark. I happened to be spending the summer of 1977 doing particle physics at Argonne National Lab, not far away from Fermilab. And it was funny: I remember there was a kind of blasé attitude toward the discovery. Like “another unexpected particle physics discovery; there’ll be lots more”.

But as it turned out that’s not what happened. It’s been 35 years, and when it comes to new particles and the like, there really hasn’t been a single surprise. (The discovery of neutrino masses is a partial counterexample, as are various discoveries in cosmology.) Experiments have certainly discovered things—the W and Z bosons, the validity of QCD, the top quark. But all of them were as expected from the Standard Model; there were no surprises.

Needless to say, verifying the predictions of the Standard Model hasn’t always been easy. A few times I happened to be at the front lines. In 1977, for example, I computed what the Standard Model predicted for the rate of producing charm particles in proton-proton collisions. But the key experiment at the time said the actual rate was much lower. I spent ages trying to figure out what might be wrong—either with my calculations or the underlying theory. But in the end—in a rather formative moment for my understanding of applying the scientific method—it turned out that what was wrong was actually the experiment, not the theory.

In 1979—when I was at the front lines of the “discovery of the gluon”—almost the opposite thing happened. The conviction in the Standard Model was by then so great that the experiments agreed too early, even before the calculations were correctly finished. Though once again, in the end all was well, and the method I invented for doing analysis of the experiments is in fact still routinely used today.

By 1981 I myself was beginning to drift away from particle physics, not least because I’d started to work on things that I thought were somehow more fundamental. But I still used to follow what was happening in particle physics. And every so often I’d get excited when I heard about some discovery rumored or announced that seemed somehow unexpected or inexplicable from the Standard Model. But in the end it was all rather disappointing. There’d be questions about each discovery—and in later years there’d often be suspicious correlations with deadlines for funding decisions. And every time, after a while, the discovery would melt away. Leaving only the plain Standard Model, with no surprises.

Through all of this, though, there was always one loose end dangling: the Higgs particle. It wasn’t clear just what it would take to see it, but if the Standard Model was correct, it had to exist.

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