Jul 28, 2016
Cancer on a Paleo-diet? Ask someone who lived 1.7 million years ago
The discovery of a foot bone dated to approximately 1.7 million years ago from the site of Swartkrans with definitive evidence of malignant cancer, pushes the oldest date for this disease back from recent times into deep prehistory. Although the exact species to which the foot bone belongs is unknown, it is clearly that of a hominin, or bipedal human relative.
In an accompanying paper appearing in the same journal, a collaborating team of scientists identify the oldest tumor ever found in the human fossil record, a benign neoplasm found in the vertebrae of the well-known Australopithecus sediba child, Karabo from the site of Malapa, and dated to almost two million years in age. The oldest previously demonstrated possible hominin tumor was found in the rib of a Neanderthal and dated to around 120,000 years old.
Edward Odes, a Wits doctoral candidate and lead author of the cancer paper, and co-author on the tumor paper, notes "Modern medicine tends to assume that cancers and tumors in humans are diseases caused by modern lifestyles and environments. Our studies show the origins of these diseases occurred in our ancient relatives millions of years before modern industrial societies existed."
The cancer in a foot bone, a metatarsal, was identified as an osteosarcoma, an aggressive form of cancer which usually affects younger individuals in modern humans, and, if untreated typically results in early death. "Due to its preservation, we don't know whether the single cancerous foot bone belongs to an adult or child, nor whether the cancer caused the death of this individual, but we can tell this would have affected the individuals' ability to walk or run," says Dr Bernhard Zipfel, a Wits scientist and an expert on the foot and locomotion of early human relatives. "In short, it would have been painful."
Lead author of the tumor paper and co-author of the cancer paper, Dr Patrick Randolph-Quinney of Wits University and the University of Central Lancashire in the UK, suggests "The presence of a benign tumor in Australopithecus sediba is fascinating not only because it is found in the back, an extremely rare place for such a disease to manifest in modern humans, but also because it is found in a child. This, in fact, is the first evidence of such a disease in a young individual in the whole of the fossil human record."
Prof. Lee Berger, an author on both papers and leader of the Malapa project where the fossil vertebra was found adds "not only has there been an assumption that these sorts of cancers and tumors are diseases of modernity, which these fossils clearly demonstrate they are not, but that we as modern humans exhibit them as a consequence of living longer, yet this rare tumor is found in a young child. The history of these types of tumors and cancers is clearly more complex than previously thought."
Both incidents of disease were diagnosed using state of the art imaging technologies including those at the European Synchrotron Research Facility in Grenoble, France, medical CT at the Charlotte Maxeke Hospital in Johannesburg, and the micro-CT facility at the Nuclear Energy Corporation of South Africa at Pelindaba.
Read more at Science Daily