Astronomy: How do brown dwarfs form?

New observations provide insights into whether the birth of the giant planets takes a similar course to that of stars.

The birth of stars is a chaotic and dynamic process, especially in the early phase, which is characterized by complex gas structures in the form of spirals and streamers.

Such structures are termed "feeding filaments" because they feed the gaseous material from the surroundings to the newly born star, akin to cosmic umbilical cords.

Cosmic umbilical cord

Brown dwarfs are celestial objects with masses less than one-tenth of the mass of the Sun.

This makes them too small to undergo nuclear fusion and shine like stars.

Before now, scientists did not know whether brown dwarfs form like sun-like stars or not.

A test of this hypothesis requires high-sensitivity and high-angular resolution observations of brown dwarfs during their earliest formation stages.

An international team led by LMU astrophysicist Dr. Basmah Riaz from the University Observatory Munich has now accomplished just that: The researchers conducted observations of the extremely young brown dwarf, Ser-emb 16, using the highly sophisticated ALMA observatory in Chile and recently published their results in the journal Monthly Notices of the Royal Astronomical Society.

"Our observations have revealed spectacular large-scale spiral and streamer structures that have never been seen before towards a newly born brown dwarf," says Riaz.

The filaments cover a vast area of about 2,000-3,000 astronomical units and are connected to Ser-emb 16. Clumps of matter were also seen around it, which themselves could potentially evolve into young brown dwarfs.

"These observations show, for the first time, the influence of the external environment, which results in asymmetric mass accretion via feeding filaments on to a brown dwarf in the making," says the astronomer.

Collapsing clumps or magnetic cores?

The spiral structures and streamers provide important clues about how brown dwarfs form.

Having simulated possible scenarios, the researchers compared them with data from the ALMA observatory.

The large structures could be explained, for example, by collisions of collapsing clumps within a star-forming region.

For this to occur, such collisions would have to happen at least once during the lifetime of star-forming cores.

"We have shown through new numerical simulations that collisions trigger the collapse of even small clumps to form brown dwarfs. Spirals and streamers of various sizes and morphologies form due to the collisions happening sideways, not head-on," says co-author Dr. Dimitris Stamatellos from the University of Central Lancashire in England.

If this model is correct, it implies a dynamic brown dwarf formation process, similar to Sun-like stars, where chaotic interactions in a star-forming environment are common from an early age.

In another scenario, the simulations showed that the observed structures correspond to the large (pseudo)-disk around a very young brown dwarf, where the (pseudo)-disk has been twisted by the rotation of the brown dwarf core in the presence of a strong magnetic field.

If this model is correct, it means the magnetic field plays an important role in the brown dwarf formation process.

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Heat stress from ocean warming harms octopus vision

While climate change has led to an increase in the abundance of octopuses, heat stress from projected ocean warming could impair their vision and impact the survivability of the species.

"We found several proteins important for vision that were affected by thermal stress," says Dr Qiaz Hua, a recent PhD graduate from the University of Adelaide's School of Biological Sciences.

"One of them is a structural protein found in high abundance in animal eye lenses to preserve lens transparency and optical clarity, and another is responsible for the regeneration of visual pigments in the photoreceptors of the eyes.

"The levels of both of these proteins were significantly reduced under projected ocean warming conditions, which suggests that octopus vision is likely to be impaired under thermal stress."

Octopuses are highly visual animals, with 70 per cent of the octopus brain dedicated to vision -- which is 20 per cent more than in humans.

"The primary functions of vision include but are not limited to visual acuity, discrimination of brightness, depth perception, motion detection and polarisation, and it is crucial for detecting predator and prey as well as for communication," says Dr Hua.

"Having impaired vision will affect an octopus's chances of survival in the wild through increased predator risk as well as lower foraging success."

To make this finding, the research team, including academics from the University of South Australia, University of California Davis, and the South Australian Research and Development Institute's aquatic sciences division, exposed Octopus berrima embryos to different temperature treatments, a control 19°C exposure, 22°C to model current summer temperatures, and 25°C to model projected summer temperatures.

"The future-projected temperature was based on the Intergovernmental Panel on Climate Change's projected increase of about 3°C of warming by 2100," Dr Hua says.

In addition to impaired vision, Dr Hua found increased ocean water temperatures would have a negative effect on octopus broods.

"We found a high mortality rate under future warming conditions. Out of three replicate octopus broods, none of the eggs hatched for two of them and less than half of the eggs hatched for the remaining brood," Dr Hua says.

"In the broods where none of the eggs hatched, the mothers died naturally while the eggs were still in early development stages.

"Because maternal care of embryos occurs in octopuses, global warming could have a simultaneous impact on multiple generations, with the low survival rate of the embryos caused by the direct effect of thermal stress as well as the indirect effect of thermal stress on the mothers.

"Our study shows that even for a highly adaptable taxon like octopuses, they may not be able to survive future ocean changes."

Other effects of higher temperatures which have been observed in octopuses include a higher metabolic rate, reduced size at maturity, and even a range shift in the distribution of some species.

"We hope that future research would examine a combination of environmental stressors including ocean acidification, warming, and deoxygenation," Dr Hua says.

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RNA that doesn't age

Certain RNA molecules in the nerve cells in the brain last a life time without being renewed. Neuroscientists from Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) have now demonstrated that this is the case together with researchers from Germany, Austria and the USA. RNAs are generally short-lived molecules that are constantly reconstructed to adjust to environmental conditions. With their findings that have now been published in the journal Science, the research group hopes to decipher the complex aging process of the brain and gain a better understanding of related degenerative diseases.

Most cells in the human body are regularly renewed, thereby retaining their vitality.

However, there are exceptions: the heart, the pancreas and the brain consist of cells that do not renew throughout the whole lifespan, and yet still have to remain in full working order.

"Aging neurons are an important risk factor for neurodegenerative illnesses such as Alzheimer's," says Prof.

Dr. Tomohisa Toda, Professor of Neural Epigenomics at FAU and at the Max Planck Center for Physics and Medicine in Erlangen.

"A basic understanding of the aging process and which key components are involved in maintaining cell function is crucial for effective treatment concepts:"

In a joint study conducted together with neuroscientists from Dresden, La Jolla (USA) and Klosterneuburg (Austria), the working group led by Toda has now identified a key component of brain aging: the researchers were able to demonstrate for the first time that certain types of ribonucleic acid (RNA) that protect genetic material exist just as long as the neurons themselves.

"This is surprising, as unlike DNA, which as a rule never changes, most RNA molecules are extremely short-lived and are constantly being exchanged," Toda explains.

In order to determine the life span of the RNA molecules, the Toda group worked together with the team from Prof.

Dr. Martin Hetzer, a cell biologist at the Institute of Science and Technology Austria (ISTA). "We succeeded in marking the RNAs with fluorescent molecules and tracking their lifespan in mice brain cells," explains Tomohisa Toda, who has unique expertise in epigenetics and neurobiology and who was awarded an ERC Consolidator Grant for his research in 2023.

"We were even able to identify the marked long-lived RNAs in two year old animals, and not just in their neurons, but also in somatic adult neural stem cells in the brain."

In addition, the researchers discovered that the long-lived RNAs, that they referred to as LL-RNA for short, tend to be located in the cells' nuclei, closely connected to chromatin, a complex of DNA and proteins that forms chromosomes.

This indicates that LL-RNA play a key role in regulating chromatin.

In order to confirm this hypothesis, the team reduced the concentration of LL-RNA in an in-vitro experiment with adult neural stem cell models, with the result that the integrity of the chromatin was strongly impaired.

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Researchers map how the brain regulates emotions

Ever want to scream during a particularly bad day, but then manage not to? Thank the human brain and how it regulates emotions, which can be critical for navigating everyday life. As we perceive events unfolding around us, the ability to be flexible and reframe a situation impacts not only how we feel, but also our behavior and decision-making.

In fact, some of the problems associated with mental health relate to individuals' inability to be flexible, such as when persistent negative thoughts make it hard to perceive a situation differently.

To help address such issues, a new Dartmouth-led study is among the first of its kind to separate activity relating to emotion generation from emotion regulation in the human brain. The findings are published in Nature Neuroscience.

"As a former biomedical engineer, it was exciting to identify some brain regions that are purely unique to regulating emotions," says lead author Ke Bo, a postdoctoral researcher in the Cognitive and Affective Neuroscience Lab (CANlab) at Dartmouth. "Our results provide new insight into how emotion regulation works by identifying targets which could have clinical applications."

For example, the systems the researchers identified could be good targets for brain stimulation to enhance the regulation of emotion.

Using computational methods, the researchers examined two independent datasets of fMRI studies obtained earlier by co-author Peter Gianaros at the University of Pittsburgh. Participants' brain activity was recorded in an fMRI scanner as they viewed images that were likely to draw a negative reaction such as a bloody scene or scary- looking animals.

The participants were then asked to recontextualize the stimulus by generating new kinds of thoughts about an image to make it less aversive, before a neutral image was presented followed by another dislikable image.

By examining the neural activity, researchers could identify the brain areas that are more active when emotions are regulated versus when emotions are generated.

The new study reveals that emotion regulation, also known in neuroscience as "reappraisal," involves particular areas of the anterior prefrontal cortex and other higher-level cortical hierarchies whose role in emotion regulation had not previously been isolated with this level of precision. These regions are involved in other high-level cognitive functions and are important for abstract thought and long-term representations of the future.

The more people are able to activate these emotion regulation-selective brain regions, the more resilient they are to experiencing something negative without letting it affect them personally. These findings build on other research linking these areas to better mental health and the ability to resist temptations and avoid drug addiction.

The results also demonstrated that the amygdala, which is known as the threat-related brain region responsible for negative emotion and has long been considered an ancient subcortical threat center, responds to aversive experiences the same way, whether people are using their thoughts to self-regulate down-regulate negative emotion or not. "It's really the cortex that is responsible for generating people's emotional responses, by changing the way we see and attach meaning to events in our environments," says Bo.

The researchers were also interested in identifying the neurochemicals that interact with emotion regulation systems. Neurotransmitters like dopamine and serotonin shape how networks of neurons communicate and are targets for both illicit drugs and therapeutic treatments alike. Some neurotransmitters may be important for enabling the ability to self-regulate or "down-regulate."

The team compared the emotion regulation brain maps from the two datasets to neurotransmitter binding maps from 36 other studies. The systems involved in regulating negative emotion overlapped with particular neurotransmitter systems.

"Our results showed that receptors for cannabinoids, opioids, and serotonin, including 5H2A, were especially rich in areas that are involved in emotion regulation," says senior author Tor Wager, the Diana L. Taylor Distinguished Professor in Neuroscience and director of the Dartmouth Brain Imaging Center at Dartmouth. "When drugs that bind to these receptors are taken, they are preferentially affecting the emotion regulation system, which raises questions about their potential for long-term effects on our capacity to self-regulate."

Serotonin is well-known for its role in depression, as the most widely used antidepressant drugs inhibit its reuptake in synapses, which transmit signals from one neuron to another.

5H2A is the serotonin receptor most strongly affected by another exciting new type of treatment for mental health -- psychedelic drugs. The study's findings suggest that the effects of drugs on depression and other mental health disorders may work in part by altering how we think about life events and our ability to self-regulate. This may help explain why drugs, particularly psychedelics, are likely to be ineffective without the right kind of psychological support. The study could help improve therapeutic approaches by increasing our understanding of why and how psychological and pharmaceutical approaches need to be combined into integrated treatments.

Read more at Science Daily

Stellar collisions produce strange, zombie-like survivors

Despite their ancient ages, some stars orbiting the Milky Way's central supermassive black hole appear deceptively youthful. But unlike humans, who might appear rejuvenated from a fresh round of collagen injections, these stars look young for a much darker reason.

They ate their neighbors.

This is just one of the more peculiar findings from new Northwestern University research. Using a new model, astrophysicists traced the violent journeys of 1,000 simulated stars orbiting our galaxy's central supermassive black hole, Sagittarius A* (Sgr A*).

So densely packed with stars, the region commonly experiences brutal stellar collisions. By simulating the effects of these intense collisions, the new work finds that collision survivors can lose mass to become stripped down, low-mass stars or can merge with other stars to become massive and rejuvenated in appearance.

"The region around the central black hole is dense with stars moving at extremely high speeds," said Northwestern's Sanaea C. Rose, who led the research. "It's a bit like running through an incredibly crowded subway station in New York City during rush hour. If you aren't colliding into other people, then you are passing very closely by them. For stars, these near collisions still cause them to interact gravitationally. We wanted to explore what these collisions and interactions mean for the stellar population and characterize their outcomes."

Rose will present this research at the American Physical Society's (APS) April meeting in Sacramento, California. "Stellar Collisions in the Galactic Center" will take place on Thursday (April 4) as part of the session "Particle Astrophysics and the Galactic Center."

Rose is the Lindheimer Postdoctoral Fellow at Northwestern's Center for Interdisciplinary Exploration and Research in Astrophysics (CIERA). She began this work as a Ph.D. candidate at UCLA.

Destined to collide

The center of our Milky Way is a strange and wild place. The gravitational pull of Sgr A* accelerates stars to whip around their orbits at terrifying speeds. And the sheer number of stars packed into the galaxy's center is upwards of a million. The densely packed cluster plus the lightning-fast speeds equal a high-speed demolition derby. In the innermost region -- within 0.1 parsecs of the black hole -- few stars escape unscathed.

"The closest star to our sun is about four light-years away," Rose explained. "Within that same distance near the supermassive black hole, there are more than a million stars. It's an incredibly crowded neighborhood. On top of that, the supermassive black hole has a really strong gravitational pull. As they orbit the black hole, stars can move at thousands of kilometers per second."

Within this tight, hectic neighborhood, stars can collide with other stars. And the closer stars live to the supermassive black hole, the likelihood of collision increases. Curious of the outcomes of these collisions, Rose and her collaborators developed a simulation to trace the fates of stellar populations in the galactic center. The simulation takes several factors into account: density of the stellar cluster, mass of the stars, orbit speed, gravity and distances from the Sgr A*.

From 'violent high fives' to total mergers

In her research, Rose pinpointed one factor that is most likely to determine a star's fate: its distance from the supermassive black hole.

Within 0.01 parsecs from the black hole, stars -- moving at speeds reaching thousands of kilometers per second -- constantly bump into one another. It's rarely a head-on collision and more like a "violent high five," as Rose describes it. The impacts are not strong enough to smash the stars completely. Instead, they shed their outer layers and continue speeding along the collision course.

"They whack into each other and keep going," Rose said. "They just graze each other as though they are exchanging a very violent high five. This causes the stars to eject some material and lose their outer layers. Depending on how fast they are moving and how much they overlap when they collide, they might lose quite a bit of their outer layers. These destructive collisions result in a population of strange, stripped down, low-mass stars."

Outside of 0.01 parsecs, stars move at a more relaxed pace -- hundreds of kilometers per second as opposed to thousands. Because of the slower speeds, these stars collide with one another but then don't have enough energy to escape. Instead, they merge to become more massive. In some cases, they might even merge multiple times to become 10 times more massive than our sun.

"A few stars win the collision lottery," Rose said. "Through collisions and mergers, these stars collect more hydrogen. Although they were formed from an older population, they masquerade as rejuvenated, young-looking stars. They are like zombie stars; they eat their neighbors."

But the youthful appearance comes at the cost of a shorter life expectancy.

"They die very quickly," Rose said. "Massive stars are sort of like giant, gas-guzzling cars. They start with a lot of hydrogen, but they burn through it very, very fast."

Extreme environment 'unlike any other'

Although Rose finds simple joy in studying the bizarre, extreme region near our galactic center, her work also can reveal information about the history of the Milky Way. And because the central cluster is extremely difficult to observe, her team's simulations can illuminate otherwise hidden processes.

"It's an environment unlike any other," Rose said. "Stars, which are under the influence of a supermassive black hole in a very crowded region, are unlike anything we will ever see in our own solar neighborhood. But if we can learn about these stellar populations, then we might be able to learn something new about how the galactic center was assembled. At the very least, it certainly provides a point of contrast for the neighborhood where we live."

Read more at Science Daily

Ocean floor a 'reservoir' of plastic pollution

New research from CSIRO, Australia's national science agency, and the University of Toronto in Canada, estimates up to 11 million tonnes of plastic pollution is sitting on the ocean floor.

Every minute, a garbage truck's worth of plastic enters the ocean.

With plastic use expected to double by 2040, understanding how and where it travels is crucial to protecting marine ecosystems and wildlife.

Dr Denise Hardesty, Senior Research Scientist with CSIRO, said this is the first estimate of how much plastic waste ends up on the ocean floor, where it accumulates before being broken down into smaller pieces and mixed into ocean sediment.

"We know that millions of tonnes of plastic waste enter our oceans every year but what we didn't know is how much of this pollution ends up on our ocean floor," Dr Hardesty said.

"We discovered that the ocean floor has become a resting place, or reservoir, for most plastic pollution, with between 3 to 11 million tonnes of plastic estimated to be sinking to the ocean floor.

"While there has been a previous estimate of microplastics on the seafloor, this research looks at larger items, from nets and cups to plastic bags and everything in between."

Ms Alice Zhu, a PhD Candidate from the University of Toronto who led the study, said the estimate of plastic pollution on the ocean floor could be up to 100 times more than the amount of plastic floating on the ocean's surface based on recent estimates.

"The ocean surface is a temporary resting place of plastic so it is expected that if we can stop plastic entering our oceans, the amount would be reduced," Ms Zhu said.

"However, our research found that plastic will continue to end up in the deep ocean, which becomes a permanent resting place or sink for marine plastic pollution,"

Scientific data was used to build two predictive models to estimate the amount and distribution of plastic on the ocean floor -- one based on data from remote operated vehicles (ROVs) and the other from bottom trawls.

Using ROV data, 3 to 11 million metric tonnes of plastic pollution is estimated to reside on the ocean floor.

The ROV results also reveal that plastic mass clusters around continents -- approximately half (46 per cent) of the predicted plastic mass on the global ocean floor resides above 200 m depth.

The ocean depths, from 200 m to as deep as 11,000 m contains the remainder of predicted plastic mass (54 per cent).

Although inland and coastal seas cover much less surface area than oceans (11 per cent vs 56 per cent out of the entire Earth's area), these areas are predicted to hold as much plastic mass as does the rest of the ocean floor.

"These findings help to fill a longstanding knowledge gap on the behaviour of plastic in the marine environment," Ms Zhu said.

"Understanding the driving forces behind the transport and accumulation of plastic in the deep ocean will help to inform source reduction and environmental remediation efforts, thereby reducing the risks that plastic pollution may pose to marine life."

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Evolution in action? New study finds possibility of nitrogen-fixing organelles

Nitrogen is a nutrient essential for all life on Earth. Although nitrogen gas (N2) is plentiful, it is largely unavailable to most organisms without a process known as nitrogen fixation, which converts dinitrogen to ammonium -- a major inorganic nitrogen source.

While there are bacteria that are able to reduce dinitrogen to ammonium, researchers at the University of Rhode Island, Institut de Ciències del Mar in Barcelona, University of California at Santa Cruz and the Massachusetts Institute of Technology have discovered nitrogen-fixing symbiotic organisms exhibiting behaviors similar to organelles.

In fact, researchers posit these symbiotic organisms -- UCYN-A, a species of cyanobacteria -- may be evolving organelle-like characteristics.

Their study was recently published in the journal Cell.

UCYN-A live in a symbiotic relationship with a closely related group of marine algae, B. bigelowii, in areas of the open ocean that are often low in nutrients.

Most nitrogen-fixing bacteria have mechanisms to regulate dinitrogen use when fixed sources of nitrogen are available, alleviating the high energetic cost of this process.

However, UCYN-A have lost the genes allowing this and are able to fix nitrogen gas into ammonium even in nutrient-rich environments.

The host, in-turn, provides it with carbon fixed photosynthetically by its chloroplasts.

The study details how researchers found a size relationship between UCYN-A and their symbiotic partner cells -- consistent with the size relationships between other organelles and their hosts.

As organelles get larger, so do their host cells - eventually dividing and replicating.

Mathematical modeling revealed the metabolic trade-offs which regulate the relative cell size through nutrient acquisition and exchange.

"It requires lots of energy as well as electrons to fix nitrogen gas, to make it into something useful," said Keisuke Inomura, assistant professor of oceanography at URI's Graduate School of Oceanography and one of the study's lead authors.

"If UCYN-A are moving along the evolutionary path toward developing into nitrogen-fixing organelles and we find cells aside from B. bigelowii also have such organelles, or are evolving similarly, it could be a game-changer."

While organelles such as mitochondria and chloroplasts are much further along on the evolutionary spectrum, researchers contend that what they are seeing may be a snapshot of the evolutionary process of bacterial-derived organelles that are nitrogen-fixing.

"Our study focuses on a much more recent symbiotic relationship that emerged about 100 million years ago, allowing us to explore the evolution of organelle formation in its early stages," explained Francisco Cornejo, co-lead author and postdoc researcher in the department of marine biology and oceanography at the Institut de Ciències del Mar.

Researchers note, however, that more study is needed to demonstrate whether this is the case.

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Discovery of how limiting damage from an asthma attack could stop disease

Scientists at King's College London have discovered a new cause for asthma that sparks hope for treatment that could prevent the life-threatening disease.

Most current asthma treatments stem from the idea that it is an inflammatory disease. Yet, the life-threatening feature of asthma is the attack or the constriction of airways, making breathing difficult. The new study, published today in Science, shows for the first time that many features of an asthma attack -- inflammation, mucus secretion, and damage to the airway barrier that prevents infections -- result from this mechanical constriction in a mouse model.

The findings suggest that blocking a process that normally causes epithelial cell death could prevent the damage, inflammation, and mucus that result from an asthma attack.

Professor Jody Rosenblatt from King's College London said: "Our discovery is the culmination of more than ten years work. As cell biologists who watch processes, we could see that the physical constriction of an asthma attack causes widespread destruction of the airway barrier. Without this barrier, asthma sufferers are far more likely to get long-term inflammation, wound healing, and infections that cause more attacks. By understanding this fundamental mechanism, we are now in a better position to prevent all these events."

In the UK, 5.4 million people have asthma and can suffer from symptoms such as wheezing, coughing, feeling breathlessness and a tight chest. Triggers such as pollen or dust can make asthma symptoms worse and can lead to a life-threatening asthma attack.

Despite the disease commonality, the causes of asthma are still not understood. Current medications treat the consequences of an asthma attack by opening the airways, calming inflammation, and breaking up the sticky mucus which clogs the airway, which help control asthma, but do not prevent it.

The answer to stopping asthma symptoms may lie in cell extrusion, a process the researchers discovered that drives most epithelial cell death. Scientists used mouse lung models and human airway tissue to discover that when the airways contract, known as bronchoconstriction, the epithelial cells that line the airway get squeezed out to later die.

Because bronchoconstriction causes so many cell extrusions, it damages the airway barrier which causes inflammation and excess mucus.

In previous studies, the scientists found that the chemical compound gadolinium can block extrusion. In this study, they found it could work in mice to prevent the excess extrusion that causes damage and inflammation after an asthma attack. The authors note that gadolinium has not been tested in humans and has not been deemed to be safe or efficacious.

Professor Rosenblatt said: "This constriction and destruction of the airways causes the post-attack inflammation and excess mucus secretion that makes it difficult for people with asthma to breathe.

"Current therapies do not prevent this destruction -- an inhaler such as Albuterol opens the airways, which is critical to breathing but, dishearteningly, we found it does not prevent the damage and the symptoms that follow an attack. Fortunately, we found that we can use an inexpensive compound, gadolinium which is frequently used for MRI imaging, to stop the airway damage in mice models as well as the ensuing inflammation and mucus secretion. Preventing this damage could then prevent the build-up of musculature that cause future attacks."

Professor Chris Brightling from the University of Leicester and one of the co-authors of the study said: "In the last decade there has been tremendous progress in therapies for asthma particularly directed towards airway inflammation. However, there remains ongoing symptoms and attacks in many people with asthma. This study identifies a new process known as epithelial extrusion whereby damage to the lining of the airway occurs as a consequence of mechanical constriction and can drive many of the key features of asthma. Better understanding of this process is likely to lead to new therapies for asthma."

Dr Samantha Walker, Director of Research and Innovation at Asthma + Lung UK, said: "Only two per cent of public health funding is allocated to developing new treatments for the 12 million people living with lung conditions in the UK so new research that can help in the treatment or prevention of asthma is good news.

"This research using an experimental mouse model shows that constricting the airways leads to damage to the lung lining and inflammation, like that seen in asthma. It is this constriction and resulting damage that makes it difficult for people with asthma to breathe.

"Current medications for asthma work by treating the inflammation, but this isn't effective for everyone. Treatments aim to prevent future asthma attacks and improve asthma control by taking inhalers every day, but we know that ~31 per cent of people with asthma don't have treatment options that work for them, putting them at risk of potentially life-threatening asthma attacks.

"This discovery opens important new doors to explore possible new treatment options desperately needed for people with asthma rather than focusing solely on inflammation."

The discovery of the mechanics behind cell extrusion could underlie other inflammatory diseases that also feature constriction such as cramping of the gut and inflammatory bowel disease.

Read more at Science Daily