Loss of Y Chromosome Linked to Alzheimer's

About one in five men over age 80 lose the Y chromosome from their blood cells, and this condition has now been linked to an increased risk of Alzheimer’s disease, researchers said.

The condition known a loss of Y, or LOY, is the most common genetic mutation acquired during a man’s lifetime.

Previous research has shown LOY can raise the likelihood of cancer and is more frequently found in smokers.

Now, researchers say the condition may serve as a predictive biomarker for a wider range of health problems.

For the study in the American Journal of Human Genetics — led by Lars Forsberg and Jan Dumanski of Uppsala University in Sweden, along with colleagues Britain, France, the United States and Canada — researchers examined cases of LOY in more than 3,200 men with an average age of 73.

Around 17 percent showed LOY in blood cells.

Those who had been already diagnosed with Alzheimer’s had a higher degree of LOY, they found.

Also, those who had not yet been diagnosed with dementia but had LOY were more likely to develop Alzheimer’s in subsequent years.

“Having loss of Y is not 100 percent predictive that you will have either cancer or Alzheimer’s,” cautioned Forsberg.

Some men with LOY in the study lived with no symptoms well into their 90s.

“But in the future, loss of Y in blood cells can become a new biomarker for disease risk and perhaps evaluation can make a difference in detecting and treating problems early.”

According to Chris Lau, professor in the department of medicine at the University of California, San Francisco, the study sheds little light on why Alzheimer’s risk may be elevated in these men.

Read more at Discovery News