A backpack full of multiple sclerosis therapy

Multiple sclerosis (MS) is a devastating autoimmune disease that destroys the protective myelin covering around nerves, disrupting communication between the brain and body, and causing patients' ability to move and function to progressively decline. The MS atlas reported in 2020 that someone is diagnosed with MS every five minutes around the world, adding to about 2.8 million individuals that currently have to live with the disease. Alarmingly, since 2013, the world-wide prevalence of MS has risen by 30%.

A key driver of MS is the sudden inflammation of nerves caused by so-called myeloid cells of the "innate" immune system in vulnerable regions of the brain and spinal cord, which together form the central nervous system (CNS). These "acute inflammatory lesions" then attract other myeloid cells, as well as self-reactive T and B cells that belong to the immune system's second arm, known as the "adaptive immune system" and directly attack the myelin covering. While no cure is available for MS, existing disease-modifying therapies in the form of small molecule and protein drugs either directly target the self-reactive immune cells or broadly dampen inflammation. However, many of those therapies cause severe side effects in different parts of the body, including the immune system itself, and thus carry significant health risks.

Now, a research team at the Wyss Institute for Biologically Inspired Engineering at Harvard University and Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) has developed a cell therapy as a strong alternative to existing small molecule and protein therapies that leverages myeloid cells, the very type of immune cells that cause the MS-triggering nerve inflammation in patients.

To transform potentially inflammatory myeloid cells into therapeutic cells, they isolated and cultured monocytes (a type of myeloid cell) from the bone marrow of donor mice and stably attached tiny microparticles, termed "backpacks," to the cells' surfaces. These backpacks are loaded with anti-inflammatory molecules that direct the carrier cells' differentiation into anti-inflammatory cells in vivo. When infused back into a mouse model of MS, the backpack-laden monocytes were able to affect MS-specific immune responses, and partially reverse hind limb paralysis and improve motor functions. The results are published in the Proceedings of the National Academy of Sciences (PNAS).

"Current MS therapies do not specifically target myeloid cells. These are very plastic cells that can toggle between different states and are thus hard to control. Our biomaterial-based backpack approach is a highly effective way to keep them locked into their anti-inflammatory state," said senior author Samir Mitragotri, Ph.D., who is a Core Faculty member at the Wyss Institute. "In many ways simpler than other cell therapies, myeloid cells can be easily obtained from patients' peripheral blood, modified with backpacks in a short culture step, and reinfused back into the original donor, where they find their way to inflammatory lesions and affect the MS-specific immune response not only locally, but more broadly." Mitragotri is also the Hiller Professor of Bioengineering and Hansjörg Wyss Professor of Biologically Inspired Engineering at SEAS.

Many cell therapies, such as the famed CAR-T cell therapies, require the mobilization of immune cells from specific tissue compartments in the body with drugs, genetic modification, and then amplification over weeks outside of the body. Myeloid cells can be directly retrieved using established methods and modified with backpacks within hours, making the therapy more easily translatable. In addition, some myeloid cell types possess the ability to traverse the blood-brain barrier, which makes them particularly suitable for treating CNS diseases.

New spin for cellular backpacks

Mitragotri's group had previously found that when they attached small disc-shaped backpacks to cells of the myeloid lineage, they remained stably exposed on the cells' surface, whereas many other cells would readily internalize and inactivate them. Adding certain molecules to the backpacks allowed the team sustained control over the cells' behavior. They made use of this finding in a tumor-fighting cell therapy consisting of backpack-laden macrophages, which is a specific type of myeloid cell. In their new study, they focused on monocytes, which also belong to the myeloid differentiation lineage and are a precursor to macrophages. Monocytes can effectively infiltrate the brain and then differentiate into macrophages, which are one of the predominant inflammatory cell types in active MS lesions.

"Because of their ability to invade the CNS, infiltrate inflammatory lesions, and differentiate into macrophages, a backpack strategy allowing control over monocyte differentiation made extreme sense," said first author Neha Kapate, a graduate student working with Mitragotri. "We decided on backpacks that contained interleukin-4 [IL-4] and dexamethasone, two molecules that we later found to provide a synergistic anti-inflammatory effect."

The team fabricated their micrometer-size backpacks via a process known as serial "spin coating," in which thin films made up of a PLGA polymer and other biocompatible substances, and containing the anti-inflammatory molecules are layered on top of each other like layers of an onion. As a final step, the outer surface of the backpack was furnished with an antibody fragment to allow it to stick to monocytes.

Cellular backpacks get legs

To test the backpack-laden monocytes for their therapeutic efficacy, the researchers isolated monocytes from healthy donor mice and, in a short cell culture step, attached the backpacks to them. They then infused the modified cells into a mouse model of MS, known among researchers as experimental autoimmune encephalomyelitis (EAE) model. "When we infused backpack-carrying monocytes and, in parallel, unaltered control monocytes into EAE mice with ongoing nerve inflammation, backpack-carrying monocytes more effectively infiltrated into inflamed CNS lesions. They also reduced inflammation inside the lesions and shifted the local and systemic MS-associated immune response towards a therapeutic outcome," said Kapate. "The resulting anti-inflammatory monocytes also elicited cross-talk effects with other immune cell populations, such as specific T helper cells that are linked to the self-directed adaptive auto-immune response."

The disease symptoms in EAE mice treated with backpack-laden monocytes were significantly improved and, by the end of the study, the animals merely exhibited a limp tail, compared to complete a paralysis in the control animals' hind limbs. The treatment also extended the animals' survival -- all mice receiving backpack-carrying monocytes survived to the end of the study, whereas a significant number of the control mice had died. Importantly, the magnitude of therapeutic benefit the team observed is on par with reported therapeutic treatments that had been tested in other studies using the same model. Since the EAE model mainly mimics the progressive form of MS and not the more prevalent "relapsing-remitting" form, with which the disease begins in about 85% of MS patients, and which at later stages can also become progressive, the team plans to also investigate their approach in models of relapsing-remitting MS. Being able to suppress inflammation early on could have enormous benefits for patients.

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Could this copycat black hole be a new type of star?

It looks like a black hole and bends light like a black hole, but it could actually be a new type of star.

Though the mysterious object is a hypothetical mathematical construction, new simulations by Johns Hopkins researchers suggest there could be other celestial bodies in space hiding from even the best telescopes on Earth. The findings are set to publish in Physical Review D.

"We were very surprised," said Pierre Heidmann, a Johns Hopkins University physicist who led the study. "The object looks identical to a black hole, but there's light coming out from its dark spot."

The detection of gravitational waves in 2015 rocked the world of astrophysics because it confirmed the existence of black holes. Inspired by those findings, the Johns Hopkins team set out to explore the possibility of other objects that could produce similar gravitational effects but that could be passing as black holes when observed with ultraprecise sensors on Earth, said co-author and Johns Hopkins physicist Ibrahima Bah.

"How would you tell when you don't have a black hole? We don't have a good way to test that," Bah said. "Studying hypothetical objects like topological solitons will help us figure that out as well."

The new simulations realistically depict an object the Johns Hopkins team calls a topological soliton. The simulations show an object looking like a blurry photo of a black hole from afar but like something else entirely up close.

The object is hypothetical at this stage. But the fact that the team could construct it using mathematical equations and show what it looks like with simulations suggests there could be other types of celestial bodies in space hiding from even the best telescopes on Earth.

The findings show how the topological soliton distorts space exactly as a black hole does -- but behaves unlike a black hole as it scrambles and releases weak light rays that would not escape the strong gravitational force of a true hole.

"Light is strongly bent, but instead of being absorbed like it would in a black hole, it scatters in funky motions until at one point it comes back to you in a chaotic manner," Heidmann said. "You don't see a dark spot. You see a lot of blur, which means light is orbiting like crazy around this weird object."

A black hole's gravitational field is so intense that light can orbit around it at a certain distance from its center, in the same way that Earth orbits the sun. This distance determines the edge of the hole's "shadow," so that any incoming light will fatally hit the region that scientists call the "event horizon." There, nothing can escape -- not even light.

The Hopkins team simulated several scenarios using pictures of outer space as if they had been captured with a camera, placing a black hole and the topological soliton in front of the lens. The results produced distorted pictures because of the gravitational effects of the massive bodies.

"These are the first simulations of astrophysically relevant string theory objects, since we can actually characterize the differences between a topological soliton and a black hole as if an observer was seeing them in the sky," Heidmann said.

Motivated by various results from string theory, Bah and Heidmann discovered ways to construct topological solitons using Einstein's theory of general relativity in 2021. While the solitons are not predictions of new objects, they serve as the best models of what new quantum gravity objects could look like compared to black holes.

Scientists have previously created models of boson stars, gravastars, and other hypothetical objects that could exert similar gravitational effects with exotic forms of matter. But the new research accounts for pillar theories of the inner workings of the universe that other models don't. It uses string theory that reconciles quantum mechanics and Einstein's theory of gravity, the researchers said.

"It's the start of a wonderful research program," Bah said. "We hope in the future to be able to genuinely propose new types of ultracompact stars consisting of new kinds of matter from quantum gravity."

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Ridgecrest faults increasingly sensitive to solid Earth tides before earthquakes

Faults in the Ridgecrest, California area were very sensitive to solid earth tidal stresses in the year and a half before the July 2019 Ridgecrest earthquake sequence, researchers reported at the Seismological Society of America (SSA)'s 2023 Annual Meeting.

"The signal of tidal modulation becomes extremely strong" after 2018, said Eric Beauce of Lamont-Doherty Earth Observatory, who noted that the signal was identified with seismicity that occurred around the faults that broke in the 2019 magnitude 7.1 earthquake.

The link does not mean that tidal stresses -- which are very small compared to other tectonic stresses -- triggered the earthquake, however.

"We don't know if something started to happen in the fault zone, something that is an indicator of the upcoming earthquake," Beauce said. "Maybe that process changed the properties of the crust in a way that made the crust be more sensitive to tidal stresses."

Pulled by the same gravitational forces of sun and moon that create ocean tides, the solid earth also deforms in the same periodic way. People can't feel the changes, but the ground deforms between 10 to 20 centimeters a day.

These solid tides "induce very, very small stress changes in the crust," Beauce explains, "which can induce stress changes in all the faults within the crust."

Although researchers have known about these tiny stress changes for more than a century, it has been difficult to extract their signal from the seismic record, and to determine whether they modulate seismicity.

In the past ten years, however, better earthquake detection and analysis techniques have made it possible to search through earthquake catalogs to find the signal of tidal stresses, Beauce said.

He and his colleagues built a rich, high-resolution earthquake catalog, using machine learning algorithms along with other techniques, for the past decade of microseismicity in the Ridgecrest area. (Microseismicity usually refers to earthquakes of magnitude 2.0 or smaller).

They found that "there is suggestive evidence that peak seismicity happens when tidal stresses are maximum," Beauce said, "but this modulation is weak, and because it is weak, it is only suggested."

Other researchers looking at the 2004 Indian Ocean and 2011 Tohoku megathrust earthquakes have detected an increase in modulation of seismicity connected to tidal stresses, decades before the earthquakes, said Beauce. And some scientists have been able to generate similar results in lab-created earthquake experiments.

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Chicken breeding in Japan dates back to fourth century BCE

Conclusive evidence of chicken breeding in the Yayoi period of Japan has been discovered from the Karako-Kagi site.

The chicken is one of the most common domesticated animals, with a current estimated population of over 33 billion individuals. They are reared for their meat and eggs, and may be kept as pets.

The chicken is believed to have been domesticated in Southeast Asia about 3500 years ago, following which they were carried to all corners of the world. The exact date of introduction of chicken breeding to Japan is under debate, as there are no historical records and archeological evidence is inconclusive.

Professor Masaki Eda at the Hokkaido University Museum led a team to uncover the earliest conclusive evidence of chicken breeding in Japan. The findings, which show chickens were bred in the Karako-Kagi site, a settlement from the Yayoi period [5th century BCE to around 2nd century BCE], were published in the journal Frontiers in Earth Sciences.

"Chickens and their wild relatives belong to a family of birds called Phasianids, which includes pheasants, turkeys and quail," explains Eda. "Bones of juvenile phasianids recovered from archeological sites could not indisputably be identified as belonging to chickens or to similarly sized wild pheasants. Identification of juveniles is important, as it would indicate that breeding of chickens took place."

The Karako-Kagi site, in what is now Tawaramoto Town, Nara Prefecture, is considered to be a settlement that played the role of a leader of the Kinki region during the Yayoi period. There are multiple archeological digs in the area; one such dig, at the 58th research point, yielded ten phasianid bones, four of which belonged to juvenile birds.

The team used a technique called Zooarchaeology by Mass Spectrometry (ZooMS) to analyze the collagen in two of the juvenile phasianid bones. Previous work by Eda had shown that domestic chicken and Japanese wild pheasants had different ZooMS fingerprints; ZooMS revealed that both the two bones belonged to chickens. The collagen from one of the bones was also carbon dated to 381-204 BCE, corresponding to the middle Yayoi period.

"Ten of the eleven previously-discovered bones of adult chickens from this period have all belonged to males; hence, it was thought chicken breeding could not have occurred on the Japanese archipelago," Eda elaborated. "By identifying bones from juvenile chickens, we provide clear evidence that breeding did occur in that time period -- which is also the earliest time chickens could have been introduced to Japan. In addition, Karako-Kagi is considered an important trade hub of the Yayoi period, so there is a possibility that this status is a factor in chicken breeding during the period."

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Grambank shows the diversity of the world's languages

Linguists have long been interested in language variation. What are common or universal patterns across languages? What limits the possible variation between them? Grambank, the world's largest and most comprehensive database of language structure, enables researchers to answer some of these questions.

Grambank was constructed in an international collaboration between the Max Planck institutes in Leipzig and Nijmegen, the Australian National University, the University of Auckland, Harvard University, Yale University, the University of Turku, Kiel University, Uppsala University, SOAS, the Endangered Languages Documentation Programme, and over a hundred scholars from around the world. Grambank's coverage spans 215 different language families and 101 isolates from all inhabited continents. "The design of the feature questionnaire initially required numerous revisions in order to encompass many of the diverse solutions that languages have evolved to code grammatical properties," says Hedvig Skirgård, who coordinated much of the coding and is the lead author of the study.

Limits on variation

The team settled on 195 grammatical properties, ranging from word order to whether or not a language has gendered pronouns. For instance, many languages have separate pronouns for 'he' and 'she', but some also have male and female versions of 'I' or 'you'. The possible 'design space' would be enormous if grammatical properties were to vary freely. Limits on variation could be related to cognitive principles rooted in memory or learning, rendering some grammatical structures more likely than others. Limits could also be related to historical 'accidents', such as descent from a common language or contact with other languages.

The researchers discovered much greater flexibility in the combination of grammatical features than many theorists have assumed. "Languages are free to vary considerably in quantifiable ways, but not without limits," explains Stephen Levinson, Director emeritus of the Max Planck Institute for Psycholinguistics in Nijmegen and one of the founders of the Grambank project. "A sign of the extraordinary diversity of the 2400 languages in our sample is that only five of them occupy the same location in design space (share the same grammatical properties)."

Languages show much greater similarity to those with a common ancestor than those they are in contact with. "Genealogy generally trumps geography," says Russell Gray, Director of the Department of Linguistic and Cultural Evolution and senior author of the study. "Nevertheless, if processes of linguistic evolution and diversification were run again from the beginning, there would still be some resemblance to what we now have. The constraints of human cognition mean that, while there is a great deal of historical contingency in the organisation of grammatical structures, there are regular patterns as well."

Diversity under threat

"The extraordinary diversity of languages is one of humanity's greatest cultural endowments," concludes Levinson. "This endowment is under threat, especially in some areas such as Northern Australia, and parts of South and Northern America. Without sustained efforts to document and revitalise endangered languages, our linguistic window into human history, cognition and culture will be seriously fragmented."

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Greenhouse gas release from permafrost is influenced by mineral binding processes

About a quarter of the organic carbon contained in ice-rich Arctic permafrost is more difficult for microorganisms to utilize. The reason for this is a strong binding of the organic material originating from dead plant remains to mineral soil particles. That is the result of a study conducted by a research group led by Professor Dr Janet Rethemeyer and Dr Jannik Martens at the University of Cologne's Institute of Geology and Mineralogy. Accurate predictions of the release of greenhouse gases from permafrost deposits are therefore more complex than previously assumed.

The results of the joint project, which was funded by the German Federal Ministry of Education and Research (BMBF), are published in the article 'Stabilization of mineral-associated organic carbon in Pleistocene permafrost' in the journal Nature Communications.

The Arctic is warming dramatically fast compared to other parts of the world. Much of it is covered by permafrost and contains large amounts of carbon, almost twice as much as the atmosphere. This carbon comes from plants that have grown over thousands of years, decomposed in the soil and then become 'frozen'. Due to strongly rising temperatures in the Arctic, this gigantic freezer is thawing fast. The old carbon stored in it can now be degraded by microorganisms, releasing carbon dioxide and methane into the atmosphere. These greenhouse gases accelerate global warming. The warmer it gets, the more greenhouse gases are in turn released from the permafrost, causing temperatures to rise further and frozen soils and sediments to thaw even faster. "There is a feedback of carbon in permafrost with climate, the strength of which depends largely on those factors that influence microbial degradation," said Janet Rethemeyer.

In the joint research project, scientists from the Institute of Zoology at the University of Cologne, the University of Tübingen, the Technical University of Munich and the Alfred-Wegener-Institute in Potsdam studied long permafrost cores from the Siberian Arctic. The cores come from very ice-rich, fine-grained sediments -- similar to loess in our latitudes -- that were deposited in large areas of Siberia and Alaska during the last ice age. The cores, up to 12 metres long, comprise sediments deposited over a period of up to 55,000 years.

The analyses of the permafrost cores show that a significant part (25-35 %) of the carbon is associated with the mineral particles and thus more difficult to access for microorganisms. "Predictions of interactions between thawing permafrost and climate are very complicated because the microbial degradability of the organic material in the sediments has varied greatly over the last 55,000 years. This is due to the different climatic conditions during this long period of deposition," Janet Rethemeyer explained. Warmer and wetter conditions resulted in poorer binding of carbon to the mineral particles, while a colder and drier climate led to stronger binding, primarily to iron oxides. Stronger binding to iron oxides means that the decomposition rates of old plant material are lower, as Professor Dr. Michael Bonkowski from the Institute of Zoology, Department of Terrestrial Ecology at the University of Cologne has shown in laboratory experiments.

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Elephant seals drift off to sleep while diving far below the ocean surface

For the first time, scientists have recorded brain activity in a free-ranging, wild marine mammal, revealing the sleep habits of elephant seals during the months they spend at sea.

The new findings, published April 20 in Science, show that while elephant seals may spend 10 hours a day sleeping on the beach during the breeding season, they average just 2 hours of sleep per day when they are at sea on months-long foraging trips. They sleep for about 10 minutes at a time during deep, 30-minute dives, often spiraling downward while fast asleep, and sometimes lying motionless on the seafloor.

First author Jessica Kendall-Bar led the study as a UC Santa Cruz graduate student working with Daniel Costa and Terrie Williams, both professors of ecology and evolutionary biology at UCSC.

"For years, one of the central questions about elephant seals has been when do they sleep," said Costa, who directs UCSC's Institute of Marine Sciences. Costa's lab has led the UCSC elephant seal research program at Año Nuevo Reserve for over 25 years, using increasingly sophisticated tags to track the movements and diving behavior of the seals during their foraging migrations, when they head out into the North Pacific Ocean for as long as 8 months.

"The dive records show that they are constantly diving, so we thought they must be sleeping during what we call drift dives, when they stop swimming and slowly sink, but we really didn't know," Costa said. "Now we're finally able to say they're definitely sleeping during those dives, and we also found that they're not sleeping very much overall compared to other mammals."

In fact, during their months at sea, elephant seals rival the record for the least sleep among all mammals, currently held by African elephants, which appear to sleep just two hours per day based on their movement patterns.

"Elephant seals are unusual in that they switch between getting a lot of sleep when they're on land, over 10 hours a day, and two hours or less when they're at sea," said Kendall-Bar, who is currently a postdoctoral fellow at UC San Diego's Scripps Institution of Oceanography.

Elephant seals are most vulnerable to predators such as sharks and killer whales when they are at the surface in the open ocean, so they only spend a minute or two breathing at the surface in between dives.

"They're able to hold their breath for a long time, so they can go into a deep slumber on these dives deep below the surface where it's safe," Kendall-Bar said.

Kendall-Bar developed a system that can reliably record brain activity (as an electroencephalogram or EEG) in wild elephant seals during their normal diving behavior at sea. With a neoprene headcap to secure the EEG sensors and a small data logger to record the signals, the system can be recovered when the animals return to the beach at Año Nuevo.

"We used the same sensors you'd use for a human sleep study at a sleep clinic and a removable, flexible adhesive to attach the headcap so that water couldn't get in and disrupt the signals," Kendall-Bar said.

In addition to the EEG system, the seals carried time-depth recorders, accelerometers, and other instruments that allowed the researchers to track the seals' movements along with the corresponding brain activity. The recordings show diving seals going into the deep sleep stage known as slow-wave sleep while maintaining a controlled glide downward, then transitioning into rapid-eye-movement (REM) sleep, when sleep paralysis causes them to turn upside down and drift downwards in a "sleep spiral."

"They go into slow-wave sleep and maintain their body posture for several minutes before they transition into REM sleep, when they lose postural control and turn upside down," Kendall-Bar said.

At the depths at which this happens, the seals are usually negatively buoyant and continue to fall passively in a corkscrew spiral "like a falling leaf," Williams said. In shallower waters over the continental shelf, elephant seals sometimes sleep while resting on the seafloor.

"It doesn't seem possible that they would truly go into paralytic REM sleep during a dive, but it tells us something about the decision-making processes of these seals to see where in the water column they feel safe enough to go to sleep," said Williams, who directs the Comparative Neurophysiology Lab at UCSC.

In developing the new EEG instrument, Kendall-Bar first deployed it on elephant seals housed temporarily in the marine mammal facilities at UCSC's Long Marine Laboratory. The next step was to deploy it on animals in the elephant seal colony at Año Nuevo Reserve north of Santa Cruz, where researchers could observe the animals on the beach.

"I spent a lot of time watching sleeping seals," Kendall-Bar said. "Our team monitored instrumented seals to make sure they were able to reintegrate with the colony and were behaving naturally."

Some of those seals took short excursions into the water, but to observe diving behavior the researchers used a translocation procedure developed by Costa's lab. Juvenile female elephant seals outfitted with the EEG sensors and trackers were transported from Año Nuevo to Monterey and released on a beach at the southern end of Monterey Bay. Over the next few days, the animals would swim back to Año Nuevo across the deep Monterey Canyon, where their dive behavior is very similar to that seen during much longer foraging trips in the open ocean.

With data on brain activity and dive behavior from 13 juvenile female elephant seals, including a total of 104 sleep dives, Kendall-Bar developed a highly accurate algorithm for identifying periods of sleep based on the dive data alone. This enabled her to estimate sleep quotas for 334 adult seals using dive data recorded over several months during their foraging trips.

"Because of the dataset that Dan Costa has curated over 25 years of working with elephant seals at Año Nuevo, I was able to extrapolate our results to over 300 animals and get a population-level look at sleep behavior," said Kendall-Bar, who now plans to use similar methods to study brain activity in other species of seals and sea lions and in human freedivers.

Williams called Kendall-Bar's work on the project a tour de force. "It's an amazing feat to pull this off," she said. "She developed an EEG system to work on an animal that's diving several hundred meters in the ocean. Then she uses the data to create data-driven animations so we can really visualize what the animal is doing as it dives through the water column."

The results may be helpful for conservation efforts by revealing a "sleepscape" of preferred resting areas, Williams said. "Normally, we're concerned about protecting the areas where animals go to feed, but perhaps the places where they sleep are as important as any other critical habitat," she said.

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Metal-poor stars are more life-friendly

Stars that contain comparatively large amounts of heavy elements provide less favourable conditions for the emergence of complex life than metal-poor stars, as scientists from the Max Planck Institutes for Solar System Research and for Chemistry as well as from the University of Göttingen have now found. The team showed how the metallicity of a star is connected to the ability of its planets to surround themselves with a protective ozone layer. Crucial to this is the intensity of the ultraviolet light that the star emits into space, in different wavelength ranges. The study provides scientists searching the sky with space telescopes for habitable star systems with important clues as to where this endeavour could be particularly promising. It also suggests a startling conclusion: as the universe ages, it becomes increasingly unfriendly to the emergence of complex life on new planets.

In the search for habitable or even inhabited planets orbiting distant stars, researchers have in the past years increasingly focused on the gas envelopes of these worlds. Do observational data show evidence of an atmosphere? Does it perhaps even contain gases such as oxygen or methane, which on Earth are produced almost exclusively as metabolic products of lifeforms? In the next years, such observations will be pushed to new limits: Nasa's James Webb Telescope will make it possible to not only characterize the atmospheres of large gas giants like Super-Neptunes, but also to analyze for the first time the much fainter spectrographic signals from rocky planet atmospheres.

With the help of numerical simulations, the current study, which was published in Nature Communications today, now turns to the ozone content of exoplanet atmospheres. As on Earth, this compound of three oxygen atoms can protect the planet's surface (and life forms residing on it) from cell-damaging ultraviolet (UV) radiation. A protective layer of ozone is thus an important prerequisite for the emergence of complex life. "We wanted to understand what properties a star must have in order for its planets to form a protective ozone layer," Anna Shapiro, scientist at the Max Planck Institute for Solar System Research and first author of the current study, explains the basic idea.

As often in science, this idea was triggered by an earlier finding. Three years ago, researchers led by the Max Planck Institute for Solar System Research had compared the Sun's brightness variations with those of hundreds of Sun-like stars. The result: the intensity of the visible light from many of these stars fluctuates much more strongly than in the case of the Sun. "We saw huge peaks in intensity," says Alexander Shapiro, who was involved in both the analyses from three years ago and the current study. "It is therefore quite possible, that the Sun, too, is capable of such spikes in intensity. In that case, also the intensity of the ultraviolet light would increase dramatically," he adds. "So naturally we wondered, what this would mean for life on Earth and what the situation is like in other star systems," says Sami Solanki, director at the Max Planck Institute for Solar System Research and co-author of both studies.

Dual role of UV radiation

At the surface of about half of all stars around which exoplanets have been shown to orbit, temperatures range from about 5,000 to about 6,000 degrees Celsius. In their calculations, the researchers therefore turned to this subgroup. With a surface temperature of approximately 5500 degrees Celsius, the Sun is also one of them. "In the Earth's atmospheric chemistry, ultraviolet radiation from the Sun plays a dual role," explains Anna Shapiro, whose past research interest focused on the influence of solar radiation on Earth's atmosphere. In reactions with individual oxygen atoms and oxygen molecules, ozone can both be created and destroyed. While long-wave UV-B radiation destroys ozone, short-wave UV-C radiation helps create protective ozone in the middle atmosphere. "It was therefore reasonable to assume that ultraviolet light may have a similarly complex influence on exoplanet atmospheres as well," the astronomer adds. The precise wavelengths are crucial.

The researchers therefore calculated exactly which wavelengths make up the ultraviolet light emitted by the stars. For the first time, they also considered the influence of metallicity. This property describes the ratio of hydrogen to heavier elements (simplistically and somewhat misleadingly called "metals" by astrophysicists) in the building material of the star. In the case of the Sun, there are more than 31000 hydrogen atoms for every iron atom. The study also considered stars with lower and higher iron content.

Simulated interactions of UV radiation with gases

In a second step, the team investigated how the calculated UV radiation would affect the atmospheres of planets orbiting at a life-friendly distance around these stars. Life-friendly distances are those that allow moderate temperatures -- neither too hot nor too cold for liquid water -- at the planet's surface. For such worlds, the team simulated on the computer exactly which processes the parent star's characteristic UV light sets in motion in the planet's atmosphere.

To compute the composition of planetary atmospheres the researchers used a chemistry-climate model that simulates the processes that control oxygen, ozone, and many other gases, and their interactions with ultraviolet light from stars, at very high spectral resolution. This model allowed the investigation of a wide variety of conditions on exoplanets and comparison with the history of the Earth's atmosphere in the last half billion years. During this period the high atmospheric oxygen content and the ozone layer were established that allowed the evolution of life on land on our planet. "It is feasible that the history of the Earth and its atmosphere holds clues about the evolution of life that may also apply to exoplanets" says Jos Lelieveld, Managing Director of the Max Planck Institute for Chemistry, who was involved in the study.

Promising candidates

The results of the simulations were surprising for the scientists. Overall, metal-poor stars emit more UV radiation than their metal-rich counterparts. But the ratio of ozone-generating UV-C radiation to ozone-destroying UV-B radiation also depends critically on metallicity: in metal-poor stars, UV-C radiation predominates, allowing a dense ozone layer to form. For metal-rich stars, with their predominant UV-B radiation, this protective envelope is much more sparse. "Contrary to expectations, metal-poor stars should thus provide more favourable conditions for the emergence of life," Anna Shapiro concludes. This finding could be helpful for future space missions such as Esa's Plato mission, which will comb through a vast array of stars for signs of habitable exoplanets. With 26 telescopes on board, the eponymous probe will be launched into space in 2026 and will focus its attention primarily on Earth-like planets orbiting Sun-like stars at life-friendly distances. The mission's data centre is currently being set up at the Max Planck Institute for Solar System Research. "Our current study gives us valuable clues as to which stars Plato should pay special attention to," says Laurent Gizon, Managing Director at the Institute and co-author of the current study.

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Long-distance quantum teleportation enabled by multiplexed quantum memories

Quantum teleportation is a technique allowing the transfer of quantum information between two distant quantum objects, a sender and a receiver, using a phenomenon called quantum entanglement as a resource. The unique feature of this process is that the actual information is not transferred by sending quantum bits (qubits) through a communication channel connecting the two parties; instead, the information is destroyed at one location and appears at the other one without physically travelling between the two. This surprising property is enabled by quantum entanglement, accompanied by the transmission of classical bits.

There is a deep interest in quantum teleportation nowadays within the field of quantum communications and quantum networks because it would allow the transfer of quantum bits between network nodes over very long distances, using previously shared entanglement. This would help the integration of quantum technologies into current telecommunication networks and extend the ultra-secure communications enabled by these systems to very long distances. In addition, quantum teleportation permits the transfer of quantum information between different kinds of quantum systems, e.g. between light and matter or between different kinds of quantum nodes.

Quantum teleportation was theoretically proposed in the early 90s and experimental demonstrations were carried out by several groups around the world. While the scientific community has gained extensive experience on how to perform these experiments, there is still an open question on how to teleport information in a practical way, allowing reliable and fast quantum communication over an extended network. It seems clear that such an infrastructure should be compatible with the current telecommunications network. In addition, the protocol of quantum teleportation requires a final operation to be applied on the teleported qubit, conditioned on the result of the teleportation measurement (transmitted by classical bits), in order to transfer the information faithfully and at a higher rate, a feature called active feed-forward. This means that the receiver requires a device known as a quantum memory that can store the qubit without degrading it until the final operation can be implemented. Finally, this quantum memory should be able to operate in a multiplexed fashion to maximize the speed of teleporting information when the sender and the receiver are far away. To date, no implementation had incorporated these three requirements in the same demonstration.

In a recent study published in Nature Communications, ICFO researchers Dario Lago-Rivera, Jelena V. Rakonjac, Samuele Grandi, led by ICREA Prof. at ICFO Hugues de Riedmatten have reported achieving long distance teleportation of quantum information from a photon to a solid-state qubit, a photon stored in a multiplexed quantum memory. The technique involved the use of an active feed-forward scheme, which, together with the multimodality of the memory, has allowed maximization of the teleportation rate. The proposed architecture was compatible with the telecommunications channels, and thus enabling future integration and scalability for long-distance quantum communication.

How to achieve quantum teleportation

The team built two experimental setups, that in the jargon of the community are usually called Alice and Bob. The two setups were connected by a 1km optical fiber spun up in a spool, to emulate a physical distance between the parties.

Three photons were involved in the experiment. In the first setup, Alice, the team used a special crystal to create two entangled photons: the first photon at 606 nm, called signal photon, and the second photon called idler photon, compatible with the telecommunications infrastructure. Once created, "we kept the first 606 nm photon at Alice and stored it in a multiplexed solid-state quantum memory, holding it in the memory for future processing. At the same time, we took the telecom photon created at Alice and sent it through the 1km of optical fiber to reach the second experimental setup, called Bob," Dario Lago recalls.

In this second setup, Bob, the scientists had another crystal where they created a third photon, where they had encoded the quantum bit they wanted to teleport. Once the third photon was created, the second photon had arrived to Bob from Alice, and this is where the core of the teleportation experiment takes place.

Teleporting information over 1km

The second and third photons interfered with each other through what is known as a Bell State measurement (BSM). The effect of this measurement was to mix the state of the second and third photon. Thanks to the fact that the first and second photons were entangled to begin with, i.e. their joint state was highly correlated, the result of the BSM was that of transferring the information encoded in the third photon to the first one, stored by Alice in the quantum memory, 1 km away. As Dario Lago and Jelena Rakonjac mention, "we are capable of transferring information between two photons that were never in contact before, but connected through a third photon that was indeed entangled with the first. The uniqueness of this experiment lies in the fact that we employed a multiplexed quantum memory capable of storing the first photon for long enough such that by the time Alice found out that the interaction had happened, we were still able to process the teleported information as the protocol requires."

This processing that Dario and Jelena mention was the active feed-forward technique mentioned earlier. Depending on the outcome of the BSM, a phase-shift was applied to the first photon after storage in the memory. In this way, the same state would always be encoded in the first photon. Without this, half of the teleportation events would have to be discarded. Moreover, the multimodality of the quantum memory allowed them to increase the teleportation rate beyond the limits imposed by the 1 km separation between them without degrading the quality of the teleported qubit. Overall, this resulted in a teleportation rate three times higher than for a single-mode quantum memory, only limited by the speed of the classical hardware.

Scalability and Integration

The experiment carried out by this group in 2021, where they achieved for the first time entanglement of two multimode quantum memories separated by 10 meters and heralded by a photon at the telecommunication wavelength, has been the precursor of this experiment.

As Hugues de Riedmatten emphasizes, "Quantum teleportation will be crucial for enabling high-quality long-distance communication for the future quantum internet. Our goal is to implement quantum teleportation in more and more complex networks, with previously distributed entanglement. The solid-state and multiplexed nature of our quantum nodes as well as their compatibility with the telecom network make them a promising approach to deploy the technology over long distance in the installed fiber network."

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Scientists identify 2022 sea urchin killer

The search for the 2022 killer that decimated the long-spined sea urchin population in the Caribbean and along Florida's east coast is over. A team of researchers organized by Mya Breitbart, Distinguished University Professor at the University of South Florida's College of Marine Science, identified a single-celled organism called a ciliate as the cause of a massive die-off event to a marine animal vital to coral reef health.

Their findings were reported in Science Advances.

"We're beyond thrilled to get to the bottom of the 2022 mystery and a bit stunned we did it so quickly," said Breitbart, senior author on the Science Advances study and an expert in marine genomics. "We had a great team in place and the tools needed to do the ocean science equivalent of a forensic investigation."

Ciliates are microscopic organisms covered in hair-like structures called cilia that help them move and eat. They are found almost anywhere there is water and most are not disease-causing agents. However, this specific species of ciliate -- called a scuticociliate -- has been implicated in die-offs of other marine species, such as sharks, in the past.

Examining urchins collected from 23 sites in the Caribbean, the research team used a series of techniques to confirm the source of the die-off event.

After identifying the ciliate in every affected urchin specimen using genomic techniques, the team grew ciliates in the lab and performed infection experiments at the USF College of Marine Science. When the pathogen was introduced to otherwise healthy urchins in an aquarium tank, the urchins died within a few days -- replicating what was taking place in the ocean and confirming the ciliate as the disease source.

"We're excited to share this information with everyone, from reef managers to additional scientists so we can explore it further and try to stop its spread," Breitbart said.

The long-spined sea urchins inhabit shallow tropical waters and feed on algae that would otherwise destroy a reef. They began to lose their spines within days of contracting an unknown disease and died in droves starting in January 2022.

A similar die-off event took place in the early 1980s, which wiped out 98 percent of the long-spined sea urchin population. The culprit of that die-off remains a mystery.

Breitbart first got the call about the unfolding die-off at the end of March 2022. She immediately assembled a team consisting of Ian Hewson, lead author on the publication and a marine ecologist at Cornell University; Christina Kellogg, a microbiologist from the U.S. Geological Survey in St. Petersburg, Fla. who has worked extensively on coral reef diseases; and USF graduate student Isabella Ritchie.

"At the time, we didn't know if this die-off was caused by pollution, stress, something else -- we just didn't know," said Hewson, an expert in diseases that cause mass die-offs of sea stars, who flew from New York to the Caribbean Islands to observe the situation.

Even with the source of the mysterious die-off uncovered, questions still remain. For example:
 

• Is this ciliate new to the area, or was it there prior to the die-off?
• If it has been there, what environmental conditions favored its growth and why did it infect the urchins?
• Can it affect other species of urchins?

"One theory we have is that the ciliate grew well under high-productivity conditions that were observed in the Caribbean when the die-off first started," Kellogg said. "We're also curious about the fact that there is some overlap in some geographic areas where this die-off occurred and where corals are declining from stony coral tissue loss disease."

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