Mysterious ripples in the Milky Way were caused by a passing dwarf galaxy

Using data from the Gaia space telescope, a team led by researchers at Lund University in Sweden has shown that large parts of the Milky Way's outer disk vibrate. The ripples are caused by a dwarf galaxy, now seen in the constellation Sagittarius, that shook our galaxy as it passed by hundreds of millions of years ago.

Our cosmic home, the Milky Way, contains between 100 and 400 billion stars. Astronomers believe that the galaxy was born 13.6 billion years ago, emerging from a rotating cloud of gas composed of hydrogen and helium. Over billions of years, the gas then collected in a rotating disk where the stars, such as our sun, were formed.

In a new study published in Monthly Notices of the Royal Astronomical Society, the research team presents their findings about the stars in the outer regions of the galactic disk.

"We can see that these stars wobble and move up and down at different speeds. When the dwarf galaxy Sagittarius passed the Milky Way, it created wave motions in our galaxy, a little bit like when a stone is dropped into a pond," Paul McMillan, the astronomy researcher at Lund Observatory who led the study, explains.

By using data from the European space telescope Gaia, the research team was able to study a much larger area of the Milky Way's disk than was previously possible. By measuring how strong the ripples are in different parts of the disc, the researchers have begun to piece together a complex puzzle, providing clues about Sagittarius' history and orbit around our home galaxy.

"At the moment, Sagittarius is slowly being torn apart, but 1-2 billion years ago it was significantly larger, probably around 20 percent of the mass of the Milky Way's disk," says Paul McMillan.

The researchers were surprised by how much of the Milky Way they could study using the data from Gaia. To date the telescope, which has been in operation since 2013, has measured the movement across the sky of approximately two billion stars and the movement towards or away from us of 33 million.

"With this new discovery, we can study the Milky Way in the same way that geologists draw conclusions about the structure of the Earth from the seismic waves that travel through it. This type of "galactic seismology" will teach us a lot about our home galaxy and its evolution," Paul McMillan concludes.

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Fossil algae, dating from 541 million years ago, offer new insights into the plant kingdom's roots

Paleontologists have identified a new genus and species of algae called Protocodium sinense which predates the origin of land plants and modern animals and provides new insight into the early diversification of the plant kingdom.

Discovered at a site in China, this 541-million-year-old fossil is the first and oldest green alga from this era to be preserved in three dimensions, enabling the researchers to investigate its internal structure and identify the new specimen with unprecedented accuracy. The study is published today in BMC Biology, opening a window into a world of evolutionary puzzles that scientists are just beginning to unravel.

"Protocodium belongs to a known lineage of green algae and has a surprisingly modern architecture, showing that these algae were already well diversified before the end of the Ediacaran period," says co-author Cédric Aria, postdoctoral fellow in the Department of Ecology & Evolutionary Biology in the Faculty of Arts & Science at the University of Toronto and based at the Royal Ontario Museum (ROM). "Its discovery touches the origin of the entire plant kingdom and puts a familiar name on the organisms that preceded the Cambrian explosion over half a billion years ago, when the world's first modern ecosystems emerged."

The newly discovered Protocodium fossils were found by a team led by Hong Hua, professor of geology, and including Shu Chai, postdoctoral researcher, both of Northwest University, Xi'an, China. It is part of the Gaojiashan biota, the name given to a significant group of exceptionally well-preserved fossils, at the Dengying Formation in the southern Shaanxi Province. In the past 20 years, this geological formation has yielded important fossil species documenting the end of the Ediacaran Period 541-million-years ago.

Organisms and their parts that do not originally absorb minerals -- unlike shells or bones -- require exceptional conditions to be preserved. In this case, the whole fossils and their fine cellular details were preserved in three dimensions due to the replacement of the original organic material by phosphate. This mode of preservation allowed the researchers to use various electron and X-ray microscopy techniques to virtually slice the fossil, unveil its internal structure with precision and ultimately identify it as a close relative of the modern Codium alga, a type of seaweed.

Protocodium fossils are small spheres half a millimetre wide, like large grains of pollen, covered by a multitude of smaller domes. Thanks to the 3D examination, the researchers determined the domed surface to be part of a complex, single cell that contains thin strands called siphons. This morphology is typical of certain modern single-celled seaweeds that contain many nuclei.

The discovery of Protocodium would call for caution when identifying generic spherical Ediacaran fossils and may imply that organisms like Codium are in fact much older and widespread. The famous Doushantuo fossil embryos, also from China and preserved in 3D, have

been at the heart of debates about the deep origin of certain animal groups. Specific stages of some of these animal-like embryos resemble the unicellular Protocodium on the outside, but 3D slicing reveals how they are comprised of many cells. On the other hand, numerous 2D, round fossils of uncertain algal or other affinity are also known from the Ediacaran and older periods, but in less detail.

"We know that seaweed-like fossils are at least one billion-years-old," says Chai, the study's first author. "But until now, flat, grainy two-dimensional preservation has made it challenging to recognize more than general morphological structures."

Green algae are photosynthetic organisms, which means they convert light and carbon dioxide into sugars and oxygen. They were therefore likely important foundations of Earth's early ecosystems, and the study suggests green algae were already established in the world's shallow waters as carbon dioxide recyclers and oxygen producers before the Cambrian explosion.

Apart from its smaller size, Protocodium appears surprisingly identical to the modern Codium, a type of green algae found in many seas worldwide. Certain types of this seaweed are notoriously invasive -- such as Codium fragile subspecies tomentosoides, dubbed "dead man's fingers" for its appearance, and spread along with commercially farmed shellfish. From an evolutionary perspective, green algae like the ancient Protocodium and land plants share a common ancestor that was thought to be about one billion to one billion and a half years old, but now likely older -- the assignment of Protocodium so close to a modern group pushes back in time the history of the entire plant kingdom.

"It's very telling that such an organism has remained practically unchanged over at least 540 million years," says Aria. "By the Ediacaran, evolution had driven it towards a stable adaptive zone -- it's been comfortable there since, and more than that, quite successful. So much so, in fact, that nowadays Codium takes advantage of global trade to easily outcompete other algal species."

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Analysis of particles of the asteroid Ryugu delivers surprising results

In December 2020, a small landing capsule brought rock particles from the asteroid Ryugu to Earth -- material from the beginnings of our solar system. The Japanese space probe Hayabusa 2 had collected the samples. Geoscientist Professor Frank Brenker and his team from Goethe University Frankfurt were among the first researchers wordwide allowed literally to "shed light" on these scientifically precious samples. In the process, they discovered areas with a massive accumulation of rare earths and unexpected structures. As part of an international research collaboration, they have now reported on this in the scientific journal Science.

Frank Brenker and his team are world leaders in a method that makes it possible to analyse the chemical composition of material in a three-dimensional and entirely non-destructive way and without complicated sample preparation -- yet with a resolution of under 100 nanometres. Resolution expresses the smallest perceptible difference between two measured values. The method's long name is "Synchrotron Radiation induced X-Ray Fluorescence Computed Tomography," in short SR-XRF-CT.

Japan had chosen Ryugu (English: Dragon's Palace) as the probe's destination because it is an asteroid which, due to its high carbon content, promised to deliver particularly extensive information about the origin of life in our solar system. The analyses conducted on 16 particles by the researchers together with the scientists in Frankfurt have now shown that Ryugu is composed of CI-type material. These are very similar to the Sun in terms of their chemical composition. So far, CI-material has only rarely been found on Earth -- material of which it was unclear how much it had been altered or contaminated when entering Earth's atmosphere or upon impact with our planet. Furthermore, the analysis confirms the assumption that Ryugu originated from a parent asteroid which formed in the outer solar nebula.

Until now, scientists had assumed that there was hardly any transport of material within the asteroid due to the low temperatures during the formation of the CI material in the early days of the solar system and therefore scarcely any possibility for a massive accumulation of elements. By means of SR-XRF-CT, however, the researchers in Frankfurt found a fine vein of magnetite -- an iron oxide mineral -- and hydroxyapatite, a phosphate mineral, in one of the grains of the asteroid. Other groups of scientists established that the structure and other magnetite-hydroxyapatite regions in the Ryugu samples must have formed at a surprisingly low temperature of under 40 °C. This finding is fundamental for interpreting almost all the results that the analysis of the Ryugu samples has generated and will generate in future.

In areas of the samples containing hydroxyapatite, Frank Brenker's team additionally detected rare earth metals -- a group of chemical elements indispensable today for alloys and glassware for high-tech applications, among others. "The rare earths occur in the hydroxyapatite of the asteroid in concentrations 100 times higher than elsewhere in the solar system," says Brenker. What's more, he says, all the elements of the rare earth metals have accumulated in the phosphate mineral to the same degree -- which is also unusual. Brenker is convinced: "This equal distribution of rare earths is a further indication that Ryugu is a very pristine asteroid that represents the beginnings of our solar system."

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Babies react to taste and smell in the womb

Scientists have recorded the first direct evidence that babies react differently to various smells and tastes while in the womb by looking at their facial expressions.

A study led by Durham University's Fetal and Neonatal Research Lab, UK, took 4D ultrasound scans of 100 pregnant women to see how their unborn babies responded after being exposed to flavours from foods eaten by their mothers.

Researchers looked at how the fetuses reacted to either carrot or kale flavours just a short time after the flavours had been ingested by the mothers.

Fetuses exposed to carrot showed more "laughter-face" responses while those exposed to kale showed more "cry-face" responses.

Their findings could further our understanding of the development of human taste and smell receptors.

The researchers also believe that what pregnant women eat might influence babies' taste preferences after birth and potentially have implications for establishing healthy eating habits.

The study is published in the journal Psychological Science.

Humans experience flavour through a combination of taste and smell. In fetuses it is thought that this might happen through inhaling and swallowing the amniotic fluid in the womb.

Lead researcher Beyza Ustun, a postgraduate researcher in the Fetal and Neonatal Research Lab, Department of Psychology, Durham University, said:

"A number of studies have suggested that babies can taste and smell in the womb, but they are based on post-birth outcomes while our study is the first to see these reactions prior to birth.

"As a result, we think that this repeated exposure to flavours before birth could help to establish food preferences post-birth, which could be important when thinking about messaging around healthy eating and the potential for avoiding 'food-fussiness' when weaning.

"It was really amazing to see unborn babies' reaction to kale or carrot flavours during the scans and share those moments with their parents."

The research team, which also included scientists from Aston University, Birmingham, UK, and the National Centre for Scientific Research-University of Burgundy, France, scanned the mothers, aged 18 to 40, at both 32 weeks and 36 weeks of pregnancy to see fetal facial reactions to the kale and carrot flavours.

Mothers were given a single capsule containing approximately 400mg of carrot or 400mg kale powder around 20 minutes before each scan. They were asked not to consume any food or flavoured drinks one hour before their scans.

The mothers also did not eat or drink anything containing carrot or kale on the day of their scans to control for factors that could affect fetal reactions.

Facial reactions seen in both flavour groups, compared with fetuses in a control group who were not exposed to either flavour, showed that exposure to just a small amount of carrot or kale flavour was enough to stimulate a reaction.

Co-author Professor Nadja Reissland, head of the Fetal and Neonatal Research Lab, Department of Psychology, Durham University, supervised Beyza Ustun's research. She said:

"Previous research conducted in my lab has suggested that 4D ultrasound scans are a way of monitoring fetal reactions to understand how they respond to maternal health behaviours such as smoking, and their mental health including stress, depression, and anxiety.

"This latest study could have important implications for understanding the earliest evidence for fetal abilities to sense and discriminate different flavours and smells from the foods ingested by their mothers."

Co-author Professor Benoist Schaal, of the National Centre for Scientific Research-University of Burgundy, France, said:

"Looking at fetuses' facial reactions we can assume that a range of chemical stimuli pass through maternal diet into the fetal environment.

"This could have important implications for our understanding of the development of our taste and smell receptors, and related perception and memory."

The researchers say their findings might also help with information given to mothers about the importance of taste and healthy diets during pregnancy.

They have now begun a follow-up study with the same babies post-birth to see if the influence of flavours they experienced in the womb affects their acceptance of different foods.

Research co-author Professor Jackie Blissett, of Aston University, said:

"It could be argued that repeated prenatal flavour exposures may lead to preferences for those flavours experienced postnatally. In other words, exposing the fetus to less 'liked' flavours, such as kale, might mean they get used to those flavours in utero.

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Why whales don't get brain damage when they swim

Special blood vessels in whale brains may protect them from pulses, caused by swimming, in their blood that would damage the brain, new UBC research has suggested.

There are many theories as to the exact use of these networks of blood vessels cradling a whale's brain and spine, known as 'retia mirabilia', or 'wonderful net', but now UBC zoologists believe they've solved the mystery, with computer modeling backing their predictions.

Land mammals such as horses experience 'pulses' in their blood when galloping, where blood pressures inside the body go up and down on every stride. In a new study, lead author Dr. Margo Lillie and her team have suggested for the first time that the same phenomenon occurs in marine mammals that swim with dorso-ventral movements; in other words, whales. And, they may have found out just why whales avoid long-term damage to the brain for this.

In all mammals, average blood pressure is higher in arteries, or the blood exiting the heart, than in veins. This difference in pressure drives the blood flow in the body, including through the brain, says Dr. Lillie, a research associate emerita in the UBC department of zoology. However, locomotion can forcefully move blood, causing spikes in pressure, or 'pulses' to the brain. The difference in pressure between the blood entering and exiting the brain for these pulses can cause damage.

Long-term damage of this kind can lead to dementia in human beings, says Dr. Lillie. But while horses deal with the pulses by breathing in and out, whales hold their breath when diving and swimming. "So if cetaceans can't use their respiratory system to moderate pressure pulses, they must have found another way to deal with the problem," says Dr. Lillie.

Dr. Lillie and colleagues theorized that the retia use a 'pulse-transfer' mechanism to ensure there is no difference in blood pressure in the cetacean's brain during movement, on top of the average difference. Essentially, rather than dampening the pulses that occur in the blood, the retia transfer the pulse in the arterial blood entering the brain to the venous blood exiting, keeping the same 'amplitude' or strength of pulse, and so, avoiding any difference in pressure in the brain itself.

The researchers collected biomechanic parameters from 11 cetacean species, including, fluking frequency, and input these data into a computer model.

"Our hypothesis that swimming generates internal pressure pulses is new, and our model supports our prediction that locomotion-generated pressure pulses can be synchronized by a pulse transfer mechanism that reduces the pulsatility of resulting flow by up to 97 per cent,"says senior author Dr. Robert Shadwick, professor emeritus in the UBC department of zoology.

The model could potentially be used to ask questions about other animals and what's happening with their blood pressure pulses when they move, including humans, says Dr. Shadwick. And while the researchers say the hypothesis still needs to be tested directly by measuring blood pressures and flow in the brain of swimming cetaceans, this is currently not ethically and technically possible, as it would involve putting a probe in a live whale.

"As interesting as they are, they're essentially inaccessible," he says. "They are the biggest animals on the planet, possibly ever, and understanding how they manage to survive and live and do what they do is a fascinating piece of basic biology."

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Common gene variant linked to COVID mortality

It may be the most baffling quirk of COVID: What manifests as minor, flu-like symptoms in some individuals spirals into severe disease, disability, and even death in others. A new paper published in Nature may explain the genetic underpinnings of this dichotomy.

The researchers demonstrated that mice with gene variants previously linked to Alzheimer's disease were at greater risk of dying when infected with COVID. And a retrospective analysis suggests that patients with those same gene variants were more likely to have died of COVID throughout the pandemic. Because three percent of the world population possesses these gene variants, the findings may have implications for hundreds of millions of individuals globally.

"It is clear that age, sex, and certain preconditions such as diabetes increase the risk of detrimental outcomes, but these factors don't fully explain the spectrum of COVID outcomes," says Sohail Tavazoie, the Leon Hess Professor at The Rockefeller University. "This is the first time that we've seen such a common genetic variant associated with COVID mortality."

A closer look at APOE

In previous work, Tavazoie's lab studied a gene called APOE that plays a role in cancer metastasis. After demonstrating that the gene suppresses the spread of melanoma and regulates anti-tumor immune responses, he and his team began looking at its different forms, or alleles, more closely. Most people have a form called APOE3, but 40 percent of the population carries at least one copy of the APOE2 or APOE4 variant. Individuals with APOE2 or APOE4 produce proteins that differ from APOE3 protein by one or two amino acids.

One or two amino acids make a difference. Individuals with APOE4 are at greater risk of developing Alzheimer's and atherosclerosis, and Tavazoie and Benjamin Ostendorf, a postdoctoral fellow in his lab, have demonstrated that APOE4 and APOE2 impact the immune response against melanoma. As the pandemic progressed, Tavazoie and Ostendorf began to wonder whether APOE variants might impact COVID outcomes, too. "We had looked only at non-infectious diseases," he says. "But what if APOE variants also made people vulnerable to an infectious agent, like SARS-CoV-2? Could they cause different immune responses against a virus?"

To find out, Tavazoie and colleagues first exposed more than 300 mice engineered to carry human APOE to a mouse-adapted version of SARS-CoV-2 produced by colleagues Hans-Heinrich Hoffmann and Charles M. Rice. They found that mice with APOE4 and APOE2 were more likely to die than those with the more common APOE3 allele. "The results were striking," says Ostendorf, lead author on the study. "A difference in just one or two amino acids in the APOE gene was sufficient to cause major differences in the survival of mice exhibiting COVID."

Mice with APOE2 and APOE4 also had more virus replicating in their lungs, and more signs of inflammation and tissue damage. At the cellular level, the researchers found that APOE3 appeared to reduce the amount of virus entering the cell, while animals with the other variants had less potent immune responses to the virus. "Taken together, these results suggest that the APOE genotype impacts COVID outcomes in two ways," Ostendorf says, "by modulating the immune response and by preventing SARS-CoV-2 from infecting cells."

Toward clinical practice

The lab then turned to retrospective human studies. In an analysis of 13,000 patients in the UK Biobank, the researchers found that individuals with two copies of either APOE4 or APOE2 were more likely to have died of COVID than those with two copies of APOE3. (Roughly three percent of individuals have two copies of APOE2 or APOE4, representing an estimated 230 million people worldwide.)

Tavazoie emphasizes that there is no evidence that the 40 percent of individuals carrying only one of these alleles are at increased risk. Moreover, he says those with two APOE2 or APOE4 alleles are likely at lower risk today than the data indicates. "Vaccination changes the picture," he explains. "Data in UK Biobank spans the length of the pandemic, and many of the individuals who died early on would likely have been protected had they been vaccinated."

Moving forward, Tavazoie hopes to see prospective studies on the link between APOE and distinct COVID outcomes. "We've taken the first step," he says. "But to be clinically useful, these results will need to be assessed in prospective human trials that test individuals for their APOE genotypes and account for the availability of vaccination, something that wasn't available early in the pandemic and would improve COVID outcomes across APOE genotypes."

If future studies do confirm a link between APOE and COVID outcomes, clinicians might recommend that individuals with APOE4 or APOE2 be prioritized for vaccinations, boosters, and antiviral therapies. Screening for APOE is fairly routine and inexpensive, and many individuals already know their APOE variants because commercial genetic tests such as 23andMe use it to gauge Alzheimer's risk. At the same time, Tavazoie cautions that screening for a gene variant linked to Alzheimer's is not without ethical hurdles, given that many people would rather not know whether they are predisposed to an incurable neurodegenerative disease.

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Astronomers detect hot gas bubble swirling around the Milky Way's supermassive black hole

Using the Atacama Large Millimeter/submillimeter Array (ALMA), astronomers have spotted signs of a 'hot spot' orbiting Sagittarius A*, the black hole at the centre of our galaxy. The finding helps us better understand the enigmatic and dynamic environment of our supermassive black hole.

"We think we're looking at a hot bubble of gas zipping around Sagittarius A* on an orbit similar in size to that of the planet Mercury, but making a full loop in just around 70 minutes. This requires a mind blowing velocity of about 30% of the speed of light!" says Maciek Wielgus of the Max Planck Institute for Radio Astronomy in Bonn, Germany, who led the study published today in Astronomy & Astrophysics.

The observations were made with ALMA in the Chilean Andes -- a radio telescope co-owned by the European Southern Observatory (ESO) -- during a campaign by the Event Horizon Telescope (EHT) Collaboration to image black holes. In April 2017 the EHT linked together eight existing radio telescopes worldwide, including ALMA, resulting in the recently released first ever image of Sagittarius A*. To calibrate the EHT data, Wielgus and his colleagues, who are members of the EHT Collaboration, used ALMA data recorded simultaneously with the EHT observations of Sagittarius A*. To the team's surprise, there were more clues to the nature of the black hole hidden in the ALMA-only measurements.

By chance, some of the observations were done shortly after a burst or flare of X-ray energy was emitted from the centre of our galaxy, which was spotted by NASA's Chandra Space Telescope. These kinds of flares, previously observed with X-ray and infrared telescopes, are thought to be associated with so-called 'hot spots', hot gas bubbles that orbit very fast and close to the black hole.

"What is really new and interesting is that such flares were so far only clearly present in X-ray and infrared observations of Sagittarius A*. Here we see for the first time a very strong indication that orbiting hot spots are also present in radio observations," says Wielgus, who is also affiliated with the Nicolaus Copernicus Astronomical Centre, Poland and the Black Hole Initiative at Harvard University, USA.

"Perhaps these hot spots detected at infrared wavelengths are a manifestation of the same physical phenomenon: as infrared-emitting hot spots cool down, they become visible at longer wavelengths, like the ones observed by ALMA and the EHT," adds Jesse Vos, a PhD student at Radboud University, the Netherlands, who was also involved in this study.

The flares were long thought to originate from magnetic interactions in the very hot gas orbiting very close to Sagittarius A*, and the new findings support this idea. "Now we find strong evidence for a magnetic origin of these flares and our observations give us a clue about the geometry of the process. The new data are extremely helpful for building a theoretical interpretation of these events," says co-author Monika Mo?cibrodzka from Radboud University.

ALMA allows astronomers to study polarised radio emission from Sagittarius A*, which can be used to unveil the black hole's magnetic field. The team used these observations together with theoretical models to learn more about the formation of the hot spot and the environment it is embedded in, including the magnetic field around Sagittarius A*. Their research provides stronger constraints on the shape of this magnetic field than previous observations, helping astronomers uncover the nature of our black hole and its surroundings.

The observations confirm some of the previous discoveries made by the GRAVITY instrument at ESO's Very Large Telescope (VLT), which observes in the infrared. The data from GRAVITY and ALMA both suggest the flare originates in a clump of gas swirling around the black hole at about 30% of the speed of light in a clockwise direction in the sky, with the orbit of the hot spot being nearly face-on.

"In the future we should be able to track hot spots across frequencies using coordinated multiwavelength observations with both GRAVITY and ALMA -- the success of such an endeavour would be a true milestone for our understanding of the physics of flares in the Galactic centre," says Ivan Marti-Vidal of the University of València in Spain, co-author of the study.

The team is also hoping to be able to directly observe the orbiting gas clumps with the EHT, to probe ever closer to the black hole and learn more about it. "Hopefully, one day, we will be comfortable saying that we 'know' what is going on in Sagittarius A*," Wielgus concludes.

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COVID-19 infections increase risk of long-term brain problems

If you've had COVID-19, it may still be messing with your brain. Those who have been infected with the virus are at increased risk of developing a range of neurological conditions in the first year after the infection, new research shows. Such complications include strokes, cognitive and memory problems, depression, anxiety and migraine headaches, according to a comprehensive analysis of federal health data by researchers at Washington University School of Medicine in St. Louis and the Veterans Affairs St. Louis Health Care system.

Additionally, the post-COVID brain is associated with movement disorders, from tremors and involuntary muscle contractions to epileptic seizures, hearing and vision abnormalities, and balance and coordination difficulties as well as other symptoms similar to what is experienced with Parkinson's disease.

The findings are published Sept. 22 in Nature Medicine.

"Our study provides a comprehensive assessment of the long-term neurologic consequences of COVID-19," said senior author Ziyad Al-Aly, MD, a clinical epidemiologist at Washington University. "Past studies have examined a narrower set of neurological outcomes, mostly in hospitalized patients. We evaluated 44 brain and other neurologic disorders among both nonhospitalized and hospitalized patients, including those admitted to the intensive care unit. The results show the devastating long-term effects of COVID-19. These are part and parcel of long COVID. The virus is not always as benign as some people think it is."

Overall, COVID-19 has contributed to more than 40 million new cases of neurological disorders worldwide, Al-Aly said.

Other than having a COVID infection, specific risk factors for long-term neurological problems are scarce. "We're seeing brain problems in previously healthy individuals and those who have had mild infections," Al-Aly said. "It doesn't matter if you are young or old, female or male, or what your race is. It doesn't matter if you smoked or not, or if you had other unhealthy habits or conditions."

Few people in the study were vaccinated for COVID-19 because the vaccines were not yet widely available during the time span of the study, from March 2020 through early January 2021. The data also predates delta, omicron and other COVID variants.

A previous study in Nature Medicine led by Al-Aly found that vaccines slightly reduce -- by about 20% -- the risk of long-term brain problems. "It is definitely important to get vaccinated but also important to understand that they do not offer complete protection against these long-term neurologic disorders," Al-Aly said.

The researchers analyzed about 14 million de-identified medical records in a database maintained by the U.S. Department of Veterans Affairs, the nation's largest integrated health-care system. Patients included all ages, races and sexes.

They created a controlled data set of 154,000 people who had tested positive for COVID-19 sometime from March 1, 2020, through Jan. 15, 2021, and who had survived the first 30 days after infection. Statistical modeling was used to compare neurological outcomes in the COVID-19 data set with two other groups of people not infected with the virus: a control group of more than 5.6 million patients who did not have COVID-19 during the same time frame; and a control group of more than 5.8 million people from March 2018 to December 31, 2019, long before the virus infected and killed millions across the globe.

The researchers examined brain health over a year-long period. Neurological conditions occurred in 7% more people with COVID-19 compared with those who had not been infected with the virus. Extrapolating this percentage based on the number of COVID-19 cases in the U.S., that translates to roughly 6.6 million people who have suffered brain impairments associated with the virus.

Memory problems -- colloquially called brain fog -- are one of the most common brain-related, long-COVID symptoms. Compared with those in the control groups, people who contracted the virus were at a 77% increased risk of developing memory problems. "These problems resolve in some people but persist in many others," Al-Aly said. "At this point, the proportion of people who get better versus those with long-lasting problems is unknown."

Interestingly, the researchers noted an increased risk of Alzheimer's disease among those infected with the virus. There were two more cases of Alzheimer's per 1,000 people with COVID-19 compared with the control groups. "It's unlikely that someone who has had COVID-19 will just get Alzheimer's out of the blue," Al-Aly said. "Alzheimer's takes years to manifest. But what we suspect is happening is that people who have a predisposition to Alzheimer's may be pushed over the edge by COVID, meaning they're on a faster track to develop the disease. It's rare but concerning."

Also compared to the control groups, people who had the virus were 50% more likely to suffer from an ischemic stroke, which strikes when a blood clot or other obstruction blocks an artery's ability to supply blood and oxygen to the brain. Ischemic strokes account for the majority of all strokes, and can lead to difficulty speaking, cognitive confusion, vision problems, the loss of feeling on one side of the body, permanent brain damage, paralysis and death.

"There have been several studies by other researchers that have shown, in mice and humans, that SARS-CoV-2 can attack the lining of the blood vessels and then then trigger a stroke or seizure," Al-Aly said. "It helps explain how someone with no risk factors could suddenly have a stroke."

Overall, compared to the uninfected, people who had COVID-19 were 80% more likely to suffer from epilepsy or seizures, 43% more likely to develop mental health disorders such as anxiety or depression, 35% more likely to experience mild to severe headaches, and 42% more likely to encounter movement disorders. The latter includes involuntary muscle contractions, tremors and other Parkinson's-like symptoms.

COVID-19 sufferers were also 30% more likely to have eye problems such as blurred vision, dryness and retinal inflammation; and they were 22% more likely to develop hearing abnormalities such as tinnitus, or ringing in the ears.

"Our study adds to this growing body of evidence by providing a comprehensive account of the neurologic consequences of COVID-19 one year after infection," Al-Aly said.

Read more at Science Daily

Shaking the dinosaur family tree: How did 'bird-hipped' dinosaurs evolve?

Researchers have conducted a new analysis of the origins of 'bird-hipped' dinosaurs -- the group which includes iconic species such as Triceratops -- and found that they likely evolved from a group of animals known as silesaurs, which were first identified two decades ago.

The researchers, from the University of Cambridge and the Universidade Federal de Santa Maria in Brazil, were attempting to solve a long-standing mystery in palaeontology: where the 'bird-hipped' dinosaurs, or ornithischians, came from.

Currently, there is a gap of more than 25 million years in the fossil record, making it difficult to find the branch of the dinosaur family tree where ornithischians belong.

The researchers conducted an extensive analysis of early dinosaurs as well as silesaurs, a group named after Silesaurus, first described in 2003. The researchers suggest that silesaurs progressively modified their anatomy during the Late Triassic Period, so that they came to resemble ornithischians by the Early Jurassic Period.

However, these ornithischian ancestors have the hip structure of the 'lizard-hipped' dinosaurs, or saurischians, suggesting that the earliest bird-hipped dinosaurs were in fact lizard-hipped. The results are reported in the Zoological Journal of the Linnean Society.

Dinosaurs originated in the Late Triassic period, about 225 million years ago, and dominated life on Earth until a mass extinction event 66 million years ago. Dinosaurs have fascinated us since they were first named as such by Richard Owen in 1842.

The earliest discovered dinosaur remains were scrappy: odd-looking teeth and a few bones. By the latter half of the 19th century however, enough dinosaur remains had been found that a classification system was needed. Harry Seeley, who had been trained in Cambridge by Adam Sedgwick, developed such a classification of dinosaurs based primarily upon the shape of their hip bones: they were either saurischians (lizard-hipped) or ornithischians (bird-hipped). This classification, first published in 1888, proved reliable: all dinosaur discoveries seemed to slot neatly into one or other of these groupings.

However, in a 2017 paper, Professor David Norman from Cambridge's Department of Earth Sciences and his former PhD students Matthew Baron and Paul Barrett argued that these dinosaur family groupings need to be rearranged, re-defined and re-named. In a study published in Nature, the researchers suggested that bird-hipped dinosaurs and lizard-hipped dinosaurs such as Tyrannosaurus evolved from a common ancestor, potentially overturning more than a century of theory about the evolutionary history of dinosaurs.

Controversy aside, it has long been recognised that the bird-hipped dinosaurs are clearly anatomically distinct from all other types of dinosaurs, even though they have nothing to do with birds. But how they came to be, has remained a long-standing problem.

"It seemed to be that they originated with all other dinosaurs in the Late Triassic but exhibited a unique set of features that could not be fitted into an evolutionary succession from their dinosaur cousins," said Norman, who is a Fellow of Christ's College. "It was as if they just suddenly appeared out of nowhere."

Recent work has begun to indicate a more varied and puzzling picture of ornithischian origins. From a phylogenetic perspective -- how the dinosaur family tree branches over time -- it is predicted that ornithischian remains should first appear in the fossil record about 225 million years ago.

"However, the more we've looked in rocks of that age, the less we've found," said Norman. "The first unarguable ornithischian remains date from less than 200 million years ago, meaning there is a 25+ million-year ornithischian gap. So far, all attempts to fill that gap have failed."

One solution to this conundrum can be traced back to a discovery in the early years of this century, when the skeleton of an unusual Late Triassic dinosaur-like animal was discovered in Poland. It was described by Jerzy Dzik and named Silesaurus (the 'Silesian lizard').

Silesaurus has long slender legs that gave it an upright dinosaur-like posture -- and its hip bones are arranged like a saurischian -- but it seemed to have a toothless, beak-like region at the front of its lower jaw. This was not unlike the toothless beak-like structure known as a predentary that is found in all ornithischian dinosaur skulls, although the uniquely ornithischian predentary bone was not present.

Its teeth were also constricted at the top of the roots, and the crowns of the teeth were leaf-shaped in profile: a type of tooth shape seen in many early ornithischians. Dzik speculated about the possible ornithischian similarities of Silesaurus, but the suggestion was dismissed or ignored by most researchers.

In the years that followed, more Silesaurus-like creatures were discovered, mostly in South America. Many of these specimens were fragments, but the toothless tip of the lower jaw and the leaf-shaped teeth were common.

The accumulation of these specimens attracted the attention of several researchers. Their analyses suggested that silesaurs were close relatives of true dinosaurs. Either they were placed on a branch just before the origin of true dinosaurs or, in some instances, they appeared as a sister group to Ornithischia. In 2020, Mauricio Garcia and Rodrigo Müller from the Universidade Federal de Santa Maria in Brazil proposed that silesaur-like creatures could sit on the branch of Dinosauria that led to Ornithischia.

"This work attracted our attention in Cambridge," said Norman. "A few years ago, I devised a research project aimed directly at the problem of how the Ornithischia came to be, and Matt was the research student on the project."

Norman and Barron began to collaborate with Rodrigo and Mauricio, enlarging the original analysis to include a range of ornithischian dinosaurs, as well as dinosaur ancestors. The outcome of their collaboration is a family tree that depicts silesaurs as a succession of animals on the stem of the branch leading to Ornithischia.

"Silesaurians progressively modified their anatomy during the Late Triassic, so that they come to resemble ornithischians," said Norman. "We have been able to trace this transition through the development of the toothless beak, the development of leaf-shaped coarse-edged teeth typical of those seen in the herbivorous ornithischians, modifications to the shoulder bones, changes in the proportions of the pelvic bones, and finally a restructuring of the muscle attachment areas on the hind legs."

The research suggests that ornithischians did not arise from nowhere. Rather, they first appeared in the Late Triassic in the guise of silesaurs that gradually rearranged their anatomy with the passage of time until recognisable ornithischians had evolved by the beginning of the Jurassic Period.

However, there is another aspect to this explanation, which is that the earliest ornithischians of the Late Triassic had none of the anatomical characteristics of true ornithischians: they lacked a predentary and, most importantly, retained the early saurischian hip construction.

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A sea change for plastic pollution: New material biodegrades in ocean water

Plastics, now ubiquitous in the modern world, have become a rising threat to human and environmental health. Around the planet, evidence of plastic pollution stretches from grocery bags in the deep sea to microplastics in our food supplies and even in our blood.

Seeking solutions to counteract the rise in plastic trash, scientists at the University of California San Diego have developed new biodegradable materials that are designed to replace conventionally used plastic. After proving their polyurethane foams biodegrade in land-based composts, an interdisciplinary team of scientists including UC San Diego biologist Stephen Mayfield and chemists Michael Burkart and Robert "Skip" Pomeroy have now shown that the material biodegrades in seawater. The results are published in the journalScience of the Total Environment.

The researchers are working to address a plastic pollution problem now described as a global environmental crisis. In 2010, researchers estimated that 8 billion kilograms of plastic enter the ocean in a single year, with a steep escalation predicted by 2025. Upon entering the ocean, plastic waste disrupts marine ecosystems, migrates to central locations and forms trash gyres such as the Great Pacific Garbage Patch, which covers an area more than 1.6 million square kilometers. These plastics never degrade, but rather break up into ever-smaller particles, eventually becoming microplastics that persist in the environment for centuries.

Working with study coauthor Samantha Clements, a marine biologist and scientific diver at Scripps Institution of Oceanography, the UC San Diego researchers conducted a series of tests of their biodegradable polyurethane materials -- currently used as foams in the first commercially available biodegradable shoes (sold by a spinoff company called Blueview) -- at Scripps' Ellen Browning Scripps Memorial Pier and Experimental Aquarium. The pier's location provided scientists the access and a unique opportunity to test materials in the natural nearshore ecosystem, which is the exact environment where rogue plastics are most likely to end up.

The team found that an assortment of marine organisms colonizes on the polyurethane foam and biodegrades the material back to their starting chemicals, which are consumed as nutrients by these microorganisms, in the ocean environment. Data from the study suggest that the microorganisms, a mix of bacteria and fungi, live throughout the natural marine environment.

"Improper disposal of plastic in the ocean breaks down into microplastics and has become an enormous environmental problem," said Mayfield, a professor in the School of Biological Sciences and director of the California Center for Algae Biotechnology. "We've shown that it's absolutely possible to make high performance plastic products that also can degrade in the ocean. Plastics should not be going into the ocean in the first place, but if they do, this material becomes food for microorganisms and not plastic trash and microplastics that harm aquatic life."

Shoes, including flip-flops, the world's most popular shoe, make up a large percentage of plastic waste that ends up in the world's oceans and landfills. To fully test and analyze their polyurethane materials, developed at UC San Diego over the last eight years, the study joined experts in biology, polymer and synthetic chemistry and marine science. Foam samples were exposed to tidal and wave dynamics and tracked for molecular and physical changes using Fourier-transform infrared spectroscopy and scanning electron microscopy. The results showed that the material started to degraded in as little as four weeks. The researchers then identified microorganisms from six marine sites around San Diego that are capable of breaking down and consuming the polyurethane material.

"No single discipline can address these universal environmental problems but we've developed an integrated solution that works on land -- and now we know also biodegrades in the ocean," said Mayfield. "I was surprised to see just how many organisms colonize on these foams in the ocean. It becomes something like a microbial reef."

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