Nations with strong women's rights likely to have better population health and faster growth

Nations with strong women's rights are more likely to have better health and faster growth than those who don't promote and protect these values, finds research published in the online journal BMJ Open.

This trend is evident in even in resource-poor countries, say the researchers.

While many parts of the world have made good economic progress, women's rights have often been overlooked, say the researchers. This is despite many countries having signed the international bill of rights for women, formally known as The Convention on the Elimination of All Forms of Discrimination Against Women (CEDAW).

The researchers wanted to find out if there might be a link between protection of women's rights, and health improvement and sustainable development, and if ultimately, women's rights might have more of an impact than economic and social, or civil and political rights alone.

They analysed databases which held information on health, human rights, and economic and social rights for 162 countries for the period 2004 to 2010.

Countries were grouped according to the respect they afforded to women's economic and social rights: high (44); moderate (51); and poor (63).

Analysis of the data showed that strong economic and social rights were associated with better/improving health outcomes, possibly because of the spend on health per head of the population, say the researchers.

But this wasn't the case when looking at countries based on women's economic and social rights.

Overall, countries with strong women's rights had better/improving health than those where women's rights were only moderately or poorly respected.

These health indicators include disease prevention, such as vaccination, reproductive health, death rates and life expectancy.

In countries where human rights, to include women's rights, were highly respected, but where access to hospital beds and doctors was nevertheless below average, health outcomes were still consistently better than average, the analysis showed.

"The results confirm that even with a lack of resources, if a country has a strong human rights structure, the health outcomes are better," the researchers write.

But countries where civil and political rights alone were highly valued had varying levels of health.

And despite some countries respecting economic, social and cultural rights, they still didn't protect women's economic and social rights.

This is an observational study, which used average health values, and as such, can't establish cause. Further research over longer time periods in countries with similar human rights trends is needed to pinpoint overarching trends, say the researchers.

But gender equality is not just a women's issue, but a development issue, they suggest.

"Since the promotion and protection of women's rights play a fundamental role for progress for states as they unite health, human rights and development, nations that have the ability to promote [women's social and economic rights]...are missing a crucial component in positive health outcomes," they write.

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Music can be a viable alternative to medications in reducing anxiety before anesthesia

Music is a viable alternative to sedative medications in reducing patient anxiety prior to an anesthesia procedure, according to a Penn Medicine study published today in the journal Regional Anesthesia & Pain Medicine.

A peripheral nerve block procedure is a type of regional anesthesia -- done in the preoperative area under ultrasound guidance -- that blocks sensations of pain from a specific area of the body. The procedure is routinely performed for a variety of outpatient orthopedic surgeries, such as hip and knee arthroscopies and elbow or hand surgeries. To reduce anxiety, which can lead to prolonged recovery and an increase in postoperative pain, patients commonly take sedative medications, like midazolam, prior to the nerve block procedure. Yet, the medications can have side effects, including breathing issues and paradoxical effects like hostility and agitation. In this study, researchers found a track of relaxing music to be similarly effective to the intravenous form of midazolam in reducing a patient's anxiety prior to the procedure.

"Our findings show that there are drug-free alternatives to help calm a patient before certain procedures, like nerve blocks," said the study's lead author Veena Graff, MD, an assistant professor of Clinical Anesthesiology and Critical Care. "We've rolled out a new process at our ambulatory surgical center to provide patients who want to listen to music with access to disposable headphones. Ultimately, our goal is to offer music as an alternative to help patients relax during their perioperative period."

While research has shown music can help reduce a patient's anxiety prior to surgery, previous studies have primarily focused on music vs. an oral form of sedative medications, which are not routinely used in the preoperative setting. In this study -- the first to compare music medicine with an intravenous form of sedative medication -- researchers aimed to measure the efficacy of music in lowering a patient's anxiety prior to conducting a peripheral nerve block.

The team randomly assigned 157 adults to receive one of two options three minutes prior to the peripheral nerve block: either an injection of 1-2 mg of midazolam, or a pair of noise canceling headphones playing Marconi Union's "Weightless," -- an eight-minute song, created in collaboration with sound therapists, with carefully arranged harmonies, rhythms, and bass lines designed specifically to calm listeners down. Researchers evaluated levels of anxiety before and after the use of each method, and found similar changes in the levels of anxiety in both groups.

However, the team noted that patients who received midazolam reported higher levels of satisfaction with their overall experience and fewer issues with communication. Researchers attribute these findings to a number of factors, including the fact they used noise canceling headphones, didn't standardize the volume of music, and didn't allow patients to select the music.

From Science Daily

Sea level rise: West Antarctic ice collapse may be prevented by snowing ocean water onto it

Antarctica illustration.

The ice sheet covering West Antarctica is at risk of sliding off into the ocean. While further ice-sheet destabilisation in other parts of the continent may be limited by a reduction of greenhouse gas emissions, the slow, yet inexorable loss of West Antarctic ice is likely to continue even after climate warming is stabilised. A collapse might take hundreds of years but will raise sea levels worldwide by more than three meters.

A team of researchers from the Potsdam Institute for Climate Impact Research (PIK) is now scrutinising a daring way of stabilising the ice sheet: Generating trillions of tons of additional snowfall by pumping ocean water onto the glaciers and distributing it with snow canons. This would mean unprecedented engineering efforts and a substantial environmental hazard in one of the world's last pristine regions -- to prevent long-term sea level rise for some of the world's most densely populated areas along coastlines from the US to China.

"The fundamental trade-off is whether we as humanity want to sacrifice Antarctica to safe the currently inhabited coastal regions and the cultural heritage that we have built and are building on our shores. It is about global metropolises, from New York to Shanghai, which in the long term will be below sea level if nothing is done" explains Anders Levermann, physicist at the Potsdam Institute for Climate Impact Research (PIK) and Columbia University and one of the authors of the study. "The West Antarctic Ice Sheet is one of the tipping elements in our climate system. Ice loss is accelerating and might not stop until the West Antarctic ice sheet is practically gone."

Unprecedented measures to stabilise the ice sheet

Warm ocean currents have reached the Amundsen Sea Sector of West Antarctica -- a region comprising several glaciers that are prone to instability due to their topographic configuration. Underwater melting of these glaciers triggered their speed-up and retreat. This is already now responsible for the largest ice loss from the continent and provides an accelerating contribution to global sea level rise. In their study, the researchers employ computer simulations to project the dynamic ice loss into the future. They confirm earlier studies suggesting that even strong reduction of greenhouse gas emissions may not prevent the collapse of the West Antarctic ice sheet.

"So we investigated what could stop a potential collapse in our simulations and increased the snowfall in the destabilised region far beyond observations," says PIK co-author Johannes Feldmann. "In fact, we find that an awful lot of snow can indeed push the ice sheet back towards a stable regime and stop the instability. In practice, this could be realized by an enormous redisposition of water masses -- pumped out of the ocean and snowed onto the ice sheet at a rate of several hundred billion tons per year over a few decades."

A tremendous trade-off between hazards and hopes

"We are fully aware of the disruptive character such an intervention would have," adds Feldmann. Uplifting, desalinating and heating the ocean water as well as powering the snow canons would require an amount of electric power in the order of several ten thousand high-end wind turbines. "Putting up such a wind farm and the further infrastructure in the Amundsen Sea and the massive extraction of ocean water itself would essentially mean losing a unique natural reserve. Further, the harsh Antarctic climate makes the technical challenges difficult to anticipate and hard to handle while the potential hazardous impacts to the region are likely to be devastating." Thus the risks and costs of such an unprecedented endeavour must be weighted very carefully against its potential benefits. "Also, our study does not consider future human-made global warming. Hence this gigantic endeavour only makes sense if the Paris Climate Agreement is kept and carbon emissions are reduced fast and unequivocally."

Read more at Science Daily

Rising CO2, climate change projected to reduce availability of nutrients worldwide

One of the biggest challenges to reducing hunger and undernutrition around the world is to produce foods that provide not only enough calories but also make enough necessary nutrients widely available. New research finds that, over the next 30 years, climate change and increasing carbon dioxide (CO2) could significantly reduce the availability of critical nutrients such as protein, iron, and zinc, compared to a future without it. The total impacts of climate change shocks and elevated levels of CO2 in the atmosphere are estimated to reduce growth in global per capita nutrient availability of protein, iron, and zinc by 19.5%, 14.4%, and 14.6%, respectively.

"We've made a lot of progress reducing undernutrition around the world recently but global population growth over the next 30 years will require increasing the production of foods that provide sufficient nutrients," explained Senior Scientist at the International Food Policy Research Institute (IFPRI) and study co-author Timothy Sulser. "These findings suggest that climate change could slow progress on improvements in global nutrition by simply making key nutrients less available than they would be without it."

The study, "A modeling approach combining elevated atmospheric CO2 effects on protein, iron and zinc availability with projected climate change impacts on global diets," [LINK] was co-authored by an international group of researchers and published in the peer-reviewed journal, Lancet Planetary Health. The study represents the most comprehensive synthesis of the impacts of elevated CO2 and climate change on the availability of nutrients in the global food supply to date.

Using the IMPACT global agriculture sector model along with data from the Global Expanded Nutrient Supply (GENuS) model and two data sets on the effects of CO2 on nutrient content in crops, researchers projected per capita availability of protein, iron, and zinc out to 2050.

Improvements in technology, and markets effects are projected to increase nutrient availability over current levels by 2050, but these gains are substantially diminished by the negative impacts of rising concentrations of carbon dioxide.

While higher levels of CO2 can boost photosynthesis and growth in some plants, previous research has also found they reduce the concentration of key micronutrients in crops. The new study finds that wheat, rice, maize, barley, potatoes, soybeans, and vegetables are all projected to suffer nutrient losses of about 3% on average by 2050 due to elevated CO2 concentration.

The effects are not likely to be felt evenly around the world, however, and many countries currently experiencing high levels of nutrient deficiency are also projected to be more affected by lower nutrient availability in the future.

Nutrient reductions are projected to be particularly severe in South Asia, the Middle East, Africa South of the Sahara, North Africa, and the former Soviet Union -- regions largely comprised of low- and middle-income countries where levels of undernutrition are generally higher and diets are more vulnerable to direct impacts of changes in temperature and precipitation triggered by climate change.

"In general, people in low- and middle-income countries receive a larger portion of their nutrients from plant-based sources, which tend to have lower bioavailability than animal-based sources," said Robert Beach, Senior Economist and Fellow at RTI International and lead author of the study.

This means that many people with already relatively low nutrient intake will likely become more vulnerable to deficiencies in iron, zinc, and protein as crops lose their nutrients. Many of these regions are also the ones expected to fuel the largest growth in populations and thus requiring the most growth in nutrient availability.

The impact on individual crops can also have disproportionate effects on diets and health. Significant nutrient losses in wheat have especially widespread implications. "Wheat accounts for a large proportion of diets in many parts of the world, so any changes in its nutrient concentrations can have substantial impact on the micronutrients many people receive," added Beach.

Protein, iron, and zinc availability in wheat are projected to be reduced by up to 12% by 2050 in all regions. People will likely experience the largest decreases in protein availability from wheat in places where wheat consumption is particularly high, including the former Soviet Union, Middle East, North Africa, and eastern Europe.

In South Asia, where the population's iron intake already sits well below the recommended level-India exhibits the highest prevalence of anemia in the world -- iron availability is projected to remain inadequate. What's more, elevated carbon levels push the average availability of zinc in the region below the threshold of recommended nutrient intake.

Although the study's models were limited to 2050, Sulser added, "extending the analysis through the second half of this century, when climate change is expected to have even stronger impacts, would result in even greater reductions in nutrient availability."

Researchers also emphasized the need for further work to build upon their findings, including additional study of climate impacts on animal sources, such as poultry, livestock, and fisheries, crops' nutritional composition, nutrient deficiencies resulting from short-term climate shocks, and technologies that could mitigate reductions in nutrient availability.

Quantifying the potential health impacts for individuals also requires a consideration of the many factors beyond food consumption -- including access to clean water, sanitation, and education -- that influence nutrition and health outcomes.

Read more at Science Daily

The unpopular truth about biases toward people with disabilities

Needing to ride in a wheelchair can put the brakes on myriad opportunities -- some less obvious than one might think. New research from Michigan State University sheds light on the bias people have toward people with disabilities, known as "ableism," and how it shifts over time.

Contrary to popular belief, the findings suggest that biases toward people with disabilities increase with age and over time, but that people are less likely to show how they really feel publicly.

"Disabilities are a sensitive, uncomfortable topic for many people to talk about. Few are willing to acknowledge a bias toward people with disabilities," said William Chopik, MSU assistant professor of psychology and senior author. "Because this is so understudied, the goal of our research was to characterize why -- and which types of -- people hold higher biases against those with disabilities."

The research, published in the Journal of Social Issues, is the largest of its kind using data from 300,000 participants gathered over 13 years. Participants ranged from 18- to 90-years-old, and 15% classified themselves as having a disability.

Authors Jenna Harder, Victor Keller and Chopik used data from Project Implicit, a platform that allows users to learn and measure biases anonymously. The platform defined a disability as "some sort of physical, mental or emotional limitation" and asked a series of questions measuring feelings about people with disabilities. The researchers also measured how much contact participants had with the disability community using a scale of one to seven, one being "knowing someone" and seven being "having constant contact" with a person with a disability.

The researchers used the surveys to measure implicit attitudes and explicit bias. Harder explained that an implicit attitude are thoughts or feelings that happen automatically, which are hard to control, suppress or regulate. Explicit attitudes, she said, are the things people consciously agree with and are more controllable because it is how people express or portray their opinions about something publicly. One can think through what they are about to say and filter themselves if necessary, she said.

The researchers found that implicit bias from respondents increased over time and with age, meaning that they had less-favorable feelings toward people with disabilities. But, when asking explicitly how much participants preferred people with disabilities to be abled, they shared more positive responses with time and age, meaning that they outwardly portrayed positive opinions about people with disabilities.

"This is a big mystery because people outwardly say they feel less biased, but in actuality the implicit attitude has been getting stronger as time goes on," Chopik said. "It's not popular to express negative opinions about people with disabilities, so perhaps they feel inclined say nicer things publicly instead. Changes in explicit attitudes do not always lead to changes in implicit prejudice -- sometimes becoming more aware of a prejudice might increase implicit prejudice."

The findings also revealed that women felt less implicit bias, and that people who had contact with the disabled population had lower prejudice.

"Some of our findings related to women align with stereotypes: when you look at how men and women compare on bias, women are more compassionate toward stigmatized groups," Harder said.

"Gender was one of the most consistent predictors in this study, supporting theories that women are particularly receptive to people who they perceive as needing help."

Chopik explained that lower prejudice from people who had contact with disabled people was consistent with theories related to interactions with other stigmatized groups.

"As you interact more with a stigmatized group, you can potentially have more positive experiences with them, which changes your attitudes," he said. "You start with a certain bias, but over time those biases are challenged and your attitude changes because you have the chance to develop positive associations with the group and see them in a different light."

Data gathered from disabled participants showed feelings of warmth among their own community and a more positive attitude toward their peers. The more visible a disability -- like needing a wheelchair or a walker -- the stronger the positive attitude toward the disability community was.

Chopik emphasized the lack of research on ableism and hopes to encourage more participation from academia.

Read more at Science Daily

Jurassic fossil shows how early mammals could swallow like their modern descendants

The 165-million-year-old fossil of Microdocodon gracilis, a tiny, shrew-like animal, shows the earliest example of modern hyoid bones in mammal evolution.

The hyoid bones link the back of the mouth, or pharynx, to the openings of the esophagus and the larynx. The hyoids of modern mammals, including humans, are arranged in a "U" shape, similar to the saddle seat of children's swing, suspended by jointed segments from the skull. It helps us transport and swallow chewed food and liquid -- a crucial function on which our livelihood depends.

Mammals as a whole are far more sophisticated than other living vertebrates in chewing up food and swallowing it one small lump at a time, instead of gulping down huge bites or whole prey like an alligator.

"Mammals have become so diverse today through the evolution of diverse ways to chew their food, weather it is insects, worms, meat, or plants. But no matter how differently mammals can chew, they all have to swallow in the same way," said Zhe-Xi Luo, PhD, a professor of organismal biology and anatomy at the University of Chicago and the senior author of a new study of the fossil, published this week in Science.

"Essentially, the specialized way for mammals to chew and then swallow is all made possible by the agile hyoid bones at the back of the throat," Luo said.

'A pristine, beautiful fossil'

This modern hyoid apparatus is mobile and allows the throat muscles to control the intricate functions to transport and swallow chewed food or drink fluids. Other vertebrates also have hyoid bones, but their hyoids are simple and rod-like, without mobile joints between segments. They can only swallow food whole or in large chunks.

When and how this unique hyoid structure first appeared in mammals, however, has long been in question among paleontologists. In 2014, Chang-Fu Zhou, PhD, from the Paleontological Museum of Liaoning in China, the lead author of the new study, found a new fossil of Microdocodon preserved with delicate hyoid bones in the famous Jurassic Daohugou site of northeastern China. Soon afterwards, Luo and Thomas Martin from the University of Bonn, Germany, met up with Zhou in China to study the fossil.

"It is a pristine, beautiful fossil. I was amazed by the exquisite preservation of this tiny fossil at the first sight. We got a sense that it was unusual, but we were puzzled about what was unusual about it," Luo said. "After taking detailed photographs and examining the fossil under a microscope, it dawned on us that this Jurassic animal has tiny hyoid bones much like those of modern mammals."

This new insight gave Luo and his colleagues added context on how to study the new fossil. Microdocodon is a docodont, from an extinct lineage of near relatives of mammals from the Mesozoic Era called mammaliaforms. Previously, paleontologists anticipated that hyoids like this had to be there in all of these early mammals, but it was difficult to identify the delicate bones. After finding them in Microdocodon, Luo and his collaborators have since found similar fossilized hyoid structures in other Mesozoic mammals.

"Now we are able for the first time to address how the crucial function for swallowing evolved among early mammals from the fossil record," Luo said. "The tiny hyoids of Microdocodon are a big milestone for interpreting the evolution of mammalian feeding function."

New insights on mammal evolution as a whole

Luo also worked with postdoctoral scholar Bhart-Anjan Bhullar, PhD, now on the faculty at Yale University, and April Neander, a scientific artist and expert on CT visualization of fossils at UChicago, to study casts of Microdocodon and reconstruct how it lived.

The jaw and middle ear of modern mammals are developed from (or around) the first pharyngeal arch, structures in a vertebrate embryo that develop into other recognizable bones and tissues. Meanwhile, the hyoids are developed separately from the second and the third pharyngeal arches. Microdocodon has a primitive middle ear still attached to the jaw like that of other early mammals like cynodonts, which is unlike the ear of modern mammals. Yet its hyoids are already like those of modern mammals.

"Hyoids and ear bones are all derivatives of the primordial vertebrate mouth and gill skeleton, with which our earliest fishlike ancestors fed and respired," Bhullar said. "The jointed, mobile hyoid of Microdocodon coexists with an archaic middle ear -- still attached to the lower jaw. Therefore, the building of the modern mammal entailed serial repurposing of a truly ancient system."

The tiny, shrew-like creature likely weighed only 5 to 9 grams, with a slender body, and an exceptionally long tail. The dimensions of its limb bones match up with those of modern tree-dwellers.

Read more at Science Daily

How mammals' brains evolved to distinguish odors is nothing to sniff at

Cat smelling flowers.

The world is filled with millions upon millions of distinct smells, but how mammals' brains evolved to tell them apart is something of a mystery.

Now, two neuroscientists from the Salk Institute and UC San Diego have discovered that at least six types of mammals -- from mice to cats -- distinguish odors in roughly the same way, using circuitry in the brain that's evolutionarily preserved across species.

"The study yields insights into organizational principles underpinning brain circuitry for olfaction in mammals that may be applied to other parts of the brain and other species," says Charles Stevens, distinguished professor emeritus in Salk's Neurobiology Laboratory and coauthor of the research published in the July 18, 2019 issue of Current Biology.

In brief, the study reveals that the size of each of the three components of the neural network for olfaction scales about the same for each species, starting with receptors in the nose that transmit signals to a cluster of neurons in the front of the brain called the olfactory bulb which, in turn, relays the signals to a "higher functioning" region for odor identification called the piriform cortex.

"These three stages scale with each other, with the relationship of the number of neurons in each stage the same across species," says Shyam Srinivasan, assistant project scientist with UC San Diego's Kavli Institute for Brain and Mind, and the paper's coauthor. "So, if you told me the number of neurons in the nose, I could predict the number in the piriform cortex or the bulb."

The current study builds on research by the same duo, published in 2018, which described how mouse brains process and distinguish odors using what's known as "distributed circuits." Unlike the visual system, for example, where information is transmitted in an orderly manner to specific parts of the visual cortex, the researchers discovered that the olfactory system in mice relies on a combination of connections distributed across the piriform cortex.

Following that paper, Stevens and Srinivasan sought to determine if the distributed neural circuitry revealed in mice is similar in other mammals. For the current work, the researchers analyzed mammal brains of varying sizes and types. Their calculations, plus previous studies over the past few years, were used to estimate brain volumes. Stevens and Srinivasan used a variety of microscopy techniques that let them visualize different types of neurons that form synapses (connections) in the olfactory circuitry.

"We couldn't count every neuron, so we did a survey," says Srinivasan. "The idea is that you take samples from different represented areas, so any irregularities are caught."

The new study revealed that the average number of synapses connecting each functional unit of the olfactory bulb (a glomerulus) to neurons in the piriform cortex is invariant across species.

"It was remarkable to see how these were conserved," says Stevens.

Specifically, identification of individual odors is linked to the strength and combination of firing neurons in the circuit that can be likened to music from a piano whose notes spring from the depression of multiple keys to create chords, or the arrangement of letters that form the words on this page.

"The discrimination of odors is based on the firing rate, the electric pulse that travels down the neuron's axon," says Srinivasan. "One odor, say for coffee, may elicit a slow response in a neuron while the same neuron may respond to chocolate at a faster rate."

This code used for olfaction is different than other parts of the brain.

"We showed that the connectivity parameters and the relationship between different stages of the olfactory circuit are conserved across mammals, suggesting that evolution has used the same design for the circuit across species, but just changed the size to fit the animals' environmental niche," says Stevens.

In the future, Stevens plans to examine other regions of the brain in search of other distributed circuits whose function is based on similar coding found in this study.

Read more at Science Daily

What makes some people more receptive to the idea of being vaccinated against infectious disease?

Fear, trust, and the likelihood of exposure are three leading factors that influence whether people are willing to be vaccinated against a virulent disease, according to a new study in the journal Heliyon, published by Elsevier.

Following the highly-publicized 2014 outbreak of Ebola in Africa and anticipating the possibility of a future Ebola outbreak in the United States, a 2014 CNN/ORC poll asked a random sample of 1,018 adults if they would take an anti-Ebola vaccination if and when it became available. About half of the participants reported that they would, while half expressed hesitation or refusal, even if vaccination services for Ebola were available to them.

In the current study, investigators conducted a secondary analysis of that data to examine the factors contributing to vaccination receptivity vs. hesitation. They found that three factors primarily influenced receptivity: a general fear orientation; trust in government to contain a crisis; and the relative chance of being exposed to the pathogen. Interestingly, the effectiveness and safety of a vaccine itself was not among the factors influencing receptivity.

"Facing a raising number of epidemics that create public health dangers, our findings indicate that vaccine hesitancy is associated with social factors that are independent of the perceived effectiveness of vaccines. Willingness to take vaccination is positively associated with a generalized sense of fear, trust in the government's ability to control an outbreak of the disease, and expectation of a potential Ebola outbreak that is imminent and proximate," explains one of the study's investigators, Kent P. Schwirian, PhD, Emeritus Professor of Sociology, The Ohio State University, Columbus, OH, USA.

Professor Schwirian elaborated on how these three factors shape the willingness of half of the sample population to engage in the protective behavior of vaccination.

• General Fear Orientation. Respondents expressed fear not only of being infected, but also more generally in terms of their outlook on life and how they perceive things are going overall in society today. The more than 60 percent who reported being somewhat or very scared about events in the US today were much more willing to consider an anti-Ebola vaccination than individuals who did not report this anxiety.
• Trust in Government. People who expressed confidence in the US government's ability to prevent an Ebola outbreak were much more willing to take the anti-Ebola vaccine than individuals who lacked confidence in the government to do so.
• Exposure Expectancy of an Ebola Outbreak. While approximately 80 percent of the respondents thought that it was somewhat or highly likely that an Ebola outbreak would happen fairly soon in the US, most people thought that the outbreak would not happen in their local community or family. However, the closer in proximity they thought the outbreak would be to them, the more willing they were to take the anti-Ebola vaccination.

Gustavo S. Mesch, PhD, Professor of Sociology and Rector, University of Haifa, Israel, the study's other investigator, recommends reexamining the research questions with more current data. "Our life and death struggle against lethal microbes is ultimately fought at the local level. Unless local hospitals and health care personnel are prepared to fight and ready to go, we are at a major disadvantage in attempting to save lives," he cautions. "Confirming what percentage of the population would opt-in or out of vaccines, and the central role of trust in the government, would help public health officials plan their responses." He added that the results also showed other factors that can be validated and explored, particularly that of older respondents who were more likely to be vaccine receptive, as were those with less formal education.

Vaccination is the primary public health response to the growing number of infectious diseases that infect the world's population. At the same time, a growing anti-vax movement has spawned a small but vocal faction of the population, spreading hesitancy despite widespread evidence of vaccine efficacy and safety. The reluctance or refusal to be vaccinated or to have one's children vaccinated was identified by the World Health Organization as one of the top ten global health threats of 2019. Understanding the factors that contribute to vaccination compliance or hesitancy is vital for controlling disease outbreaks.

Read more at Science Daily

Correcting historic sea surface temperature measurements

Researchers found a "statistical nightmare" in comparing ocean temperature readings taken on different vessels in different time periods.

Something odd happened in the oceans in the early 20th century. The North Atlantic and Northeast Pacific appeared to warm twice as much as the global average while the Northwest Pacific cooled over several decades.

Atmospheric and oceanic models have had trouble accounting for these differences in temperature changes, leading to a mystery in climate science: why did the oceans warm and cool at such different rates in the early 20th century?

Now, research from Harvard University and the UK's National Oceanography Centre points to an answer both as mundane as a decimal point truncation and as complicated as global politics. Part history, part climate science, this research corrects decades of data and suggests that ocean warming occurred in a much more homogenous way.

The research is published in Nature.

Humans have been measuring and recording the sea surface temperature for centuries. Sea surface temperatures helped sailors verify their course, find their bearings, and predict stormy weather.

Until the 1960s, most sea surface temperature measurements were taken by dropping a bucket into the ocean and measuring the temperature of the water inside.

The National Oceanic and Atmospheric Administration (NOAA) and the National Science Foundation's National Center for Atmospheric Research (NCAR) maintains a collection of sea surface temperature readings dating back to the early 19th Century. The database contains more than 155 million observations from fishing, merchant, research and navy ships from all over the world. These observations are vital to understanding changes in ocean surface temperature over time, both natural and anthropogenic.

They are also a statistical nightmare.

How do you compare, for example, the measurements of a British Man-of-War from 1820 to a Japanese fishing vessel from 1920 to a U.S. Navy ship from 1950? How do you know what kind of buckets were used, and how much they were warmed by sunshine or cooled by evaporation while being sampled?

For example, a canvas bucket left on a deck for three minutes under typical weather conditions can cool by 0.5 degrees Celsius more than a wooden bucket measured under the same conditions. Given that global warming during the 20th Century was about 1 degree Celsius, the biases associated with different measurement protocols requires careful accounting.

"There are gigabytes of data in this database and every piece has a quirky story," said Peter Huybers, Professor of Earth and Planetary Sciences and of Environmental Science and Engineering at the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) and senior author of the paper. "The data is rife with peculiarities."

A lot of research has been done to identify and adjust for these peculiarities. In 2008, for example, researchers found that a 0.3-degree Celsius jump in sea surface temperatures in 1945 was the result of measurements taken from engine room intakes. Even with these corrections, however, the data is far from perfect and there are still unexplained changes in sea surface temperature.

In this research, Huybers and his colleagues proposed a comprehensive approach to correcting the data, using a new statistical technique that compares measurements taken by nearby ships.

"Our approach looks at the differences in sea surface temperature measurements from distinct groups of ships when they pass nearby, within 300 kilometers and two days of one another," said Duo Chan, a graduate student in the Harvard Graduate School of Arts and Sciences and first author of the paper. "Using this approach, we found 17.8 million near crossings and identified some big biases in some groups."

The researchers focused on data from 1908 to 1941, broken down by the country of origin of the ship and the "decks," a term stemming from the fact that marine observations were stored using decks of punch cards. One deck includes observations from both Robert Falcon Scott's and Ernest Shackleton's voyages to the Antarctic.

"These data have made a long journey from the original logbooks to the modern archive and difficult choices were made to fit the available information onto punch cards or a manageable number of magnetic tape reels," said Elizabeth Kent, a co-author from the UK National Oceanography Centre. "We now have both the methods and the computer power to reveal how those choices have affected the data, and also pick out biases due to variations in observing practice by different nations, bringing us closer to the real historical temperatures."

The researchers found two new key causes of the warming discrepancies in the North Pacific and North Atlantic.

The first had to do with changes in Japanese records. Prior to 1932, most records of sea surface temperature from Japanese vessels in the North Pacific came from fishing vessels. This data, spread across several different decks, was originally recorded in whole-degrees Fahrenheit, then converted to Celsius, and finally rounded to tenths-of-a-degree.

However, in the lead-up to World War II, more and more Japanese readings came from naval ships. These data were stored in a different deck and when the U.S. Air Force digitized the collection, they truncated the data, chopping off the tenths-of-a-degree digits and recording the information in whole-degree Celsius.

Unrecognized effects of truncation largely explain the rapid cooling apparent in foregoing estimate of Pacific sea surface temperatures between 1935 and 1941, said Huybers. After correcting for the bias introduced by truncation, the warming in the Pacific is much more uniform.

While Japanese data holds the key to warming in the Pacific in the early 20th century, it's German data that plays the most important role in understanding sea surface temperatures in the North Atlantic during the same time.

In the late 1920s, German ships began providing a majority of data in the North Atlantic. Most of these measurements are collected in one deck, which, when compared to nearby measurements, is significantly warmer. When adjusted, the warming in the North Atlantic becomes more gradual.

With these adjustments, the researchers found that rates of warming across the North Pacific and North Atlantic become much more similar and have a warming pattern closer to what would be expected from rising greenhouse gas concentrations. However, discrepancies still remain and the overall rate of warming found in the measurements is still faster than predicted by model simulations.

Read more at Science Daily

Scientists discover how mosquito brains integrate diverse sensory cues to find a host

Mosquito biting.

For female mosquitoes, finding their next meal is all about smelling and seeing.

Through behavioral experiments and real-time recording of the female mosquito brain, a team of scientists, led by researchers at the University of Washington, has discovered how the mosquito brain integrates signals from two of its sensory systems -- visual and olfactory -- to identify, track and hone in on a potential host for her next blood meal.

Their findings, published July 18 in the journal Current Biology, indicate that, when the mosquito's olfactory system detects certain chemical cues, they trigger changes in the mosquito brain that initiate a behavioral response: The mosquito begins to use her visual system to scan her surroundings for specific types of shapes and fly toward them, presumably associating those shapes with potential hosts.

Only female mosquitoes feed on blood, and these results give scientists a much-needed glimpse of the sensory-integration process that the mosquito brain uses to locate a host. Scientists can use these findings to help develop new methods for mosquito control and reduce the spread of mosquito-borne diseases.

This study focused on the olfactory cue that triggers the hunt for a host: carbon dioxide, or CO2. For mosquitoes, smelling CO2 is a telltale sign that a potential meal is nearby.

"Our breath is just loaded with CO2," said corresponding author Jeffrey Riffell, a UW professor of biology. "It's a long-range attractant, which mosquitoes use to locate a potential host that could be more than 100 feet away."

That potential host could be a person or another warm-blooded animal. Prior research by Riffell and his collaborators has shown that smelling CO2 can "prime" the mosquito's visual system to hunt for a host. In this new research, they measure how CO2 triggers precise changes in mosquito flight behavior and visualize how the mosquito brain responds to combinations of olfactory and visual cues.

The team collected data from approximately 250 individual mosquitoes during behavioral trials conducted in a small circular arena, about 7 inches in diameter. A 360-degree LED display framed the arena and a tungsten wire tether in the middle held each mosquito. An optical sensor below the insect collected data about mosquito wingbeats, an air inlet and vacuum line streamed odors into the arena, and the LED display showed different types of visual stimuli.

The team tested how tethered Aedes aegypti mosquitoes responded to visual stimuli as well as puffs of CO2-rich air. They found that, in the arena, one-second puffs of air containing 5% CO2 -- just above the 4.5% CO2 air emitted by humans -- prompted the mosquitoes to beat their wings faster. Some visual elements like a fast-moving starfield had little effect on mosquito behavior. But if the arena showed a horizontally moving bar, mosquitoes beat their wings faster and attempted to steer in the same direction. This response was more pronounced if researchers introduced a puff of CO2 before showing the bar.

To get a clear picture of how smelling CO2 first affected flight behavior, they analyzed their data using a mathematical model of housefly flight behavior.

"We found that CO2 influences the mosquito's ability to turn toward an object that isn't directly in their flight path," said Riffell. "When they smell the CO2, they essentially turn toward the object in their visual field faster and more readily than they would without CO2."

The researchers repeated the arena experiments with a genetically modified Aedes aegypti strain created by Riffell and co-author Omar Akbari, an assistant professor at the University of California, San Diego. Cells in these mosquitoes glow fluorescent green if they contain high levels of calcium ions -- including neurons of the central nervous system when they are actively firing. In the arena, the researchers removed a small portion of the mosquito skull and used a microscope to view neuronal activity in sections of the brain in real time.

The team focused on 59 "regions of interest" that showed especially high levels of calcium ion levels in the lobula, a part of the mosquito brain's optic lobe. If the mosquito was shown a horizontal bar, two-thirds of those regions lit up, indicating increased neuronal firing in response to the visual stimulus. When the researchers introduced a puff of CO2 first and then showed the horizontal bar, 23% of the regions had even higher activity than before -- indicating that the CO2 odor prompted a larger-magnitude response in these areas of the brain that control vision.

The researchers tried the reverse experiment -- seeing if a horizontal bar triggered increased firing in the parts of the mosquito brain that control smell -- but saw no response.

"Smell triggers vision, but vision does not trigger the sense of smell," said Riffell.

Their findings align with the general picture of mosquito senses. The mosquito sense of smell operates at long distances, picking up scents more than 100 feet away. But their eyesight is most effective for objects 15 to 20 feet away, according to Riffell.

"Olfaction is a long-range sense for mosquitoes, while vision is for intermediate-range tracking," said Riffell. "So, it makes sense that we see an odor -- in this case CO2 -- affecting parts of the mosquito brain that control vision, and not the reverse."

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