Astronomers discover first step toward planet formation

Astronomers have gotten very good at spotting the signs of planet formation around stars. But for a complete understanding of planet formation, we also need to study examples where planet formation has not yet started. Looking for something and not finding it can be even more difficult than finding it sometimes, but new detailed observations of the young star DG Taurus show that it has a smooth protoplanetary disk without signs of planet formation. This successful non-detection of planet formation may indicate that DG Taurus is on the eve of planet formation.

Planets form in disks of gas and dust, known as protoplanetary disks, around protostars, young stars still in the process of forming. Planet growth is so slow that it's not possible to watch the evolution as it happens, so astronomers observe many protostars at slightly different stages of planet formation to build up a theoretical understanding.

This time an international research team led by Satoshi Ohashi at the National Astronomical Observatory of Japan (NAOJ) used the Atacama Large Millimeter/submillimeter Array (ALMA) to conduct high-resolution observations of a protoplanetary disk around a relatively young protostar, DG Taurus located 410 light-years away in the direction of the constellation Taurus. The team found that DG Taurus has a smooth protoplanetary disk, without any rings which would indicate that planets are forming. This led the team to believe that DG Taurus system will start forming planets in the future.

The team found that in this pre-planet-formation stage, the dust grains within 40 AU (about twice the size of the orbit of Uranus in the Solar System) of the central protostar are still small, while beyond this radius the dust grains have started to grow in size, the first step in planet formation. This is contrary to theoretical expectations that planet formation starts in the inner part of the disk.

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Ancient carbon in rocks releases as much carbon dioxide as the world's volcanoes

A new study led by the University of Oxford has overturned the view that natural rock weathering acts as a CO2 sink, indicating instead that this can also act as a large CO2 source, rivalling that of volcanoes. The results, published today in the journal Nature, have important implications for modelling climate change scenarios.

Rocks contain an enormous store of carbon in the ancient remains of plants and animals that lived millions of years ago. This means that the "geological carbon cycle" acts as a thermostat that helps to regulate the Earth's temperature. For instance, during chemical weathering rocks can suck up CO2 when certain minerals are attacked by the weak acid found in rainwater. This process helps to counteract the continuous CO2 released by volcanoes around the world, and forms part of Earth's natural carbon cycle that has helped keep the surface habitable to life for a billion years or more.

However, for the first time this new study measured an additional natural process of CO2 release from rocks to the atmosphere, finding that it is as significant as the CO2 released from volcanoes around the world. Currently, this process is not included in most models of the natural carbon cycle.

The process occurs when rocks that formed on ancient seafloors (where plants and animals were buried in sediments) are pushed back up to Earth's surface, for example when mountains like the Himalayas or Andes form. This exposes the organic carbon in the rocks to oxygen in the air and water, which can react and release CO2. This means that weathering rocks could be a source of CO2, rather than the commonly assumed sink.

Up to now, measuring the release of this CO2 from weathering organic carbon in rocks has proved difficult. In the new study, the researchers used a tracer element (rhenium) which is released into water when rock organic carbon reacts with oxygen. Sampling river water to measure rhenium levels makes it possible to quantify CO2 release. However, sampling all river water in the world to get a global estimate would be a significant challenge.

To upscale over Earth's surface, the researchers did two things. First, they worked out how much organic carbon is present in rocks near the surface. Second, they worked out where these were being exposed most rapidly, by erosion in steep, mountain locations.

Dr Jesse Zondervan, the researcher who led the study at the Department of Earth Sciences, University of Oxford, said: "The challenge was then how to combine these global maps with the river data, while considering uncertainties. We fed all of our data into a supercomputer at Oxford, simulating the complex interplay of physical, chemical, and hydrological processes. By piecing together this vast planetary jigsaw, we could finally estimate the total carbon dioxide emitted as these rocks weather and exhale their ancient carbon into the air."

This could then be compared to how much CO2 could be drawn down by natural rock weathering of silicate minerals. The results identified many large areas where weathering was a CO2 source, challenging the current view about how weathering impacts the carbon cycle. Hotspots of CO2 release were concentrated in mountain ranges with high uplift rates that cause sedimentary rocks to be exposed, such as the eastern Himalayas, the Rocky Mountains, and the Andes. The global CO2 release from rock organic carbon weathering was found to be 68 megatons of carbon per year.

Professor Robert Hilton (Department of Earth Sciences, University of Oxford), who leads the ROC-CO2 research project that funded the study, said: "This is about 100 times less than present day human CO2 emissions by burning fossil fuels, but it is similar to how much CO2 is released by volcanoes around the world, meaning it is a key player in Earth's natural carbon cycle."

These fluxes could have changed during Earth's past. For instance, during periods of mountain building that bring up many rocks containing organic matter, the CO2 release may have been higher, influencing global climate in the past.

Ongoing and future work is looking into how changes in erosion due to human activities, alongside the increased warming of rocks due to anthropogenic climate changes, could increase this natural carbon leak. A question the team are now asking is if this natural CO2 release will increase over the coming century. "Currently we don't know -- our methods allow us to provide a robust global estimate, but not yet assess how it could change'' says Hilton.

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Survival of the newest: the mammals that survive mass extinctions aren't as 'boring' as scientists thought

When an asteroid hit the Earth 66 million years ago, it set off a devastating mass extinction. The dinosaurs (except for a few birds) all died out, along with lots of the mammals. But some small mammals survived, laying the groundwork for all the mammals alive today. For decades, scientists have assumed that mammals and their relatives that survived challenging times (like those during mass extinctions) made it because they were generalists that were able to eat just about anything and adapt to whatever life threw at them. A new study into the mammal family tree through multiple mass extinctions revealed that the species that survived aren't as generic as scientists had thought: instead, having new and different traits can be the key to succeeding in the aftermath of a catastrophe.

"The idea of the 'survival of the unspecialized' goes back to the 1800s, and the conventional wisdom is that generalized animals are the least likely to go extinct. But we found that the ones that survived more often only seemed generalized in hindsight, when compared with their later descendents. They were actually pretty advanced animals for their time, with new traits that might have helped them survive and provided evolutionary flexibility," says Ken Angielczyk, the MacArthur Curator of Paleomammalogy at the Field Museum and senior author of the study in Nature Ecology and Evolution.

"What's been thought previously is that every time a new group of mammals evolves, you start out with a small generalist animal, since when disaster strikes, those are the guys that keep on trucking -- they can hide anywhere, they can eat whatever is around," says Spencer Hellert, an Assistant Professor at Columbia College Chicago, a research associate at the Field Museum, and co-lead author of the study. "The kind of mammal that survives a mass extinction won't be a specialist like a panda bear that can only eat bamboo."

David Grossnickle, an Assistant Professor at the Oregon Institute of Technology and co-lead author, published a study in 2019 that highlighted how small, insect-eating mammals are often the lineages that survive challenging times, including the extinction event that killed the dinosaurs, and serve as forerunners of major diversifications. He approached Hellert and Angielczyk to see if that trend held true for earlier mammals and their ancestors.

Hellert created a massive family tree of the synapsids, the group of animals of which mammals are the last surviving members. This family tree is one of the largest fossil trees ever produced, and it takes into account all the previous family trees made by scientists for this group. This method is a more formal, rigorous, and repeatable way to summarize information from lots of trees instead of just picking a few and sticking them together.

"We couldn't test this idea without a humongous family tree," says Angielczyk, "along with general information about the animals' diets and body sizes. Then we looked at what happened over time through the five major evolutionary radiations in synapsids," when a few species branched out into greater diversity. When a new disaster led the majority of those species to go extinct, the process repeated itself.

The researchers, including co-authors Graeme Lloyd and Christian Kammerer, found that the story of synapsid evolution wasn't one of "survival of the small and unspecialized." At some points, larger synapsids were the ones that survived, and the winners weren't just generalist insect-eaters.

"We were pretty surprised -- it's pretty well-established that those mammal radiations go from these small insectivores into the bigger taxa repeatedly, so I was kind of expecting to see that as we went back into synapsid history. And when we went back, that pattern starts to disappear," says Grossnickle.

While some of the survivors of mass extinctions at first appeared to be unspecialized, closer analysis revealed that they had newer, more novel characteristics. For instance, many mammals from the time of the dinosaurs had teeth that were good for cutting into prey. A few had tooth structures that acted like a mortar and pestle and were able to grind in addition to just cutting. This "fancier" tooth may have been an advantage in hard times with less food availability, because this more specialized tooth structure would have let them eat a wider variety of food.

These findings don't mean that hyper-specialized animals, like pandas that only eat bamboo, are less vulnerable to the threat of extinction than more generalist species, like raccoons that can eat a wider variety of foods. Instead, the study shows that the mammal relatives that made it through mass extinctions aren't as generic as previously assumed.

"Animals with novel traits like new tooth features, or jaws that work a little better at breaking down different food items, don't really take over ecologically until the incumbent, older lineages go extinct," says Grossnickle. "You often need an extinction event like the one that killed the dinosaurs to knock out some of those older groups, and then it allows those fancier animals to persist and diversify."

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Natural GM crops: Grasses take evolutionary shortcut by borrowing genes from their neighbors

Grass may transfer genes from their neighbours in the same way genetically modified crops are made, a new study has revealed.

Research, led by the University of Sheffield, is the first to show the frequency at which grasses incorporate DNA from other species into their genomes through a process known as lateral gene transfer.

The stolen genetic secrets give them an evolutionary advantage by allowing them to grow faster, bigger or stronger and adapt to new environments quicker.

Understanding the rate is important to know the potential impact it can have on a plant's evolution and how it adapts to the environment.

Grasses are the most ecologically and economically important group of plants, covering 30% of the earth's terrestrial surface and producing a majority of our food.

The Sheffield team sequenced multiple genomes of a species of tropical grass and determined at different time points in its evolution how many genes were acquired -- giving a rate of accumulation.

It is now thought these transfers are likely to occur in the same way that some genetically modified crops are made.

These findings, published in the journal New Phytologist could inform future work to harness the process to improve crop productivity and make more resilient crops, and have implications on how we view and use controversial GM crops.

Dr. Luke Dunning, Research Fellow from the University of Sheffield's School of Biosciences, and senior author of the research, said: "There are many methods to make GM crops, some which require substantial human intervention and some that don't. Some of these methods that require minimal human intervention could occur naturally and facilitate the transfers we have observed in wild grasses.

"These methods work by contaminating the reproductive process with DNA from a third individual. Our current working hypothesis, and something we plan to test in the near future, is that these same methods are responsible for the gene transfers we document in wild grasses.

"This means, in the near future, controversial genetic modification could be perceived as more of a natural process.

"Currently, these 'natural' reproductive contamination methods are not as efficient in producing GM plants as those that are used routinely, but by further understanding how lateral gene transfer occurs in the wild we may be able to increase the success of this process."

Since Darwin, much of our understanding of evolution has been based on the assumption that genetic information is passed from parents to offspring -- the rule of common descent for plant and animal evolution.

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Plot thickens in hunt for ninth planet

A pair of theoretical physicists are reporting that the same observations inspiring the hunt for a ninth planet might instead be evidence within the solar system of a modified law of gravity originally developed to understand the rotation of galaxies.

Researchers Harsh Mathur, a professor of physics at Case Western Reserve University, and Katherine Brown, an associate professor of physics at Hamilton College, made the assertion after studying the effect the Milky Way galaxy would have on objects in the outer solar system -- if the laws of gravity were governed by a theory known as Modified Newtonian Dynamics (or MOND).

MOND proposes Isaac Newton's famous law of gravity is valid up to a point. That is, when the gravitational acceleration predicted by Newton's law becomes small enough, MOND allows for a different gravitational behavior to take over.

The observational success of MOND on galactic scales is why some scientists consider it an alternative to "dark matter," the term physicists use to describe a hypothesized form of matter that would have gravitational effects but not emit any light.

"MOND is really good at explaining galactic-scale observations," Mathur said, "but I hadn't expected that it would have noticeable effects on the outer solar system."

Their work was recently published in The Astronomical Journal.

A 'striking' alignment

Mathur and Brown had studied MOND's effect on galactic dynamics before. But they became interested in MOND's more local effects after astronomers announced in 2016 that a handful of objects in the outer solar system showed orbital anomalies that could be explained by a ninth planet.

Orbital peculiarities have led to historic discoveries before: Neptune was discovered through its gravitational tug on the orbits of nearby object, the minute precession of Mercury provided early evidence in support of Einstein's theory of general relativity, and astronomers have recently used orbital dynamics to infer the presence of a supermassive black hole at the center of our Galaxy.

Brown realized MOND's predictions might be at odds with the observations that had motivated the search for a ninth planet. "We wanted to see if the data that support the Planet Nine hypothesis would effectively rule out MOND," she said.

Instead, Mathur and Brown found MOND predicts precisely clustering that astronomers have observed. Over millions of years, they argue, the orbits of some objects in the outer solar system would be dragged into alignment with the galaxy's own gravitational field.

When they plotted the orbits of the objects from the Planet Nine dataset against the galaxy's own gravitational field, "the alignment was striking," Mathur said.

The authors caution that the current dataset is small and that that any number of other possibilities might prove to be correct; other astronomers have argued the orbital peculiarities are the result of observational bias, for example.

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Climate change brings earlier arrival of intense hurricanes

Intense tropical cyclones are one of the most devastating natural disasters in the world due to torrential rains, flooding, destructive winds, and coastal storm surges. New research co-authored by a University of Hawai'i at Manoa atmospheric scientist revealed that since the 1980s, Category 4 and 5 hurricanes (maximum wind speed greater than 131 miles per hour) have been arriving three to four days earlier with each passing decade of climate change. Their findings were published recently in Nature.

"When intense tropical cyclones occur earlier than usual, they cause unexpected problems for communities," said Pao-Shin Chu, atmospheric sciences professor in the UH Manoa School of Ocean and Earth Science and Technology and Hawai'i State Climatologist. "Moreover, the earlier advance of these storms will overlap with other weather systems, for example local thunderstorms or seasonal monsoon rainfall, and can produce compounding extreme events and strain the emergency response."

Changes in many characteristics of intense hurricanes under a warming climate, for example, the number, intensity, and lifespan, are fairly well-studied. However, little is known about changes in the seasonal cycle of these intense events.

Using satellite data, historical tropical cyclone tracks, NOAA rainfall records, and various statistical methods, Chu and co-authors found that there has been a significant shift of these intense tropical cyclones from autumn to summer months since the 1980s in most tropical oceans. The effect was particularly observed in the eastern North Pacific off the coast of Mexico, where most hurricanes near Hawai'i come from; the western North Pacific; the South Pacific; the Gulf of Mexico; and the Atlantic coast of Florida and the Caribbean.

"It was surprising to consistently see earlier arrivals when we independently assessed satellite data and conventional ground-based observations of intense tropical cyclones," said Chu.

In August 2017, for example, Hurricane Harvey, a Category 4 hurricane, made landfall on Texas and Louisiana and inflicted catastrophic flooding and more than 100 deaths.

Using simulations from multiple global climate models (e.g., high-resolution CMIP6 models), the team detected warmer oceanic conditions developed earlier, which favored the earlier onset of intense tropical cyclones. Further, they found that the warming was primarily driven by greenhouse gas forcing.

"In a future with high carbon dioxide emissions, the earlier shifting trend is projected to be amplified," said Chu.

In South China and the Gulf of Mexico, the earlier onset of intense tropical cyclones contributes significantly to an earlier onset of extreme rainfall.

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The medicine of the future could be artificial life forms

Creating artificial life is a recurring theme in both science and popular literature, where it conjures images of creeping slime creatures with malevolent intentions or super-cute designer pets. At the same time, the question arises: What role should artificial life play in our environment here on Earth, where all life forms are created by nature and have their own place and purpose?

Associate professor Chenguang Lou from the Department of Physics, Chemistry, and Pharmacy, University of Southern Denmark, together with Professor Hanbin Mao from Kent State University, is the parent of a special artificial hybrid molecule that could lead to the creation of artificial life forms. They have now published a review in the journal Cell Reports Physical Science on the state of research in the field behind their creation. The field is called "hybrid peptide-DNA nanostructures," and it is an emerging field, less than ten years old.

Lou's vision is to create viral vaccines (modified and weakened versions of a virus) and artificial life forms that can be used for diagnosing and treating diseases.

"In nature, most organisms have natural enemies, but some do not. For example, some disease-causing viruses have no natural enemy. It would be a logical step to create an artificial life form that could become an enemy to them," he says.

Similarly, he envisions such artificial life forms can act as vaccines against viral infection and can be used as nanorobots or nanomachines loaded with medication or diagnostic elements and sent into a patient's body.

"An artificial viral vaccine may be about 10 years away. An artificial cell, on the other hand, is on the horizon because it consists of many elements that need to be controlled before we can start building with them. But with the knowledge we have, there is, in principle, no hindrance to produce artificial cellular organisms in the future," he says.

What are the building blocks that Lou and his colleagues in this field will use to create viral vaccines and artificial life? DNA and peptides are some of the most important biomolecules in nature, making DNA technology and peptide technology the two most powerful molecular tools in the nanotechnological toolkit today. DNA technology provides precise control over programming, from the atomic level to the macro level, but it can only provide limited chemical functions since it only has four bases: A, C, G, and T. Peptide technology, on the other hand, can provide sufficient chemical functions on a large scale, as there are 20 amino acids to work with. Nature uses both DNA and peptides to build various protein factories found in cells, allowing them to evolve into organisms.

Recently, Hanbin Mao and Chenguang Lou have succeeded in linking designed three-stranded DNA structures with three-stranded peptide structures, thus creating an artificial hybrid molecule that combines the strengths of both. This work was published in Nature Communications in 2022.

Elsewhere in the world, other researchers are also working on connecting DNA and peptides because this connection forms a strong foundation for the development of more advanced biological entities and life forms.

At Oxford University, researchers have succeeded in building a nanomachine made of DNA and peptides that can drill through a cell membrane, creating an artificial membrane channel through which small molecules can pass. (Spruijt et al., Nat. Nanotechnol. 2018, 13, 739-745)

At Arizona State University, Nicholas Stephanopoulos and colleagues have enabled DNA and peptides to self-assemble into 2D and 3D structures. (Buchberger et al., J. Am. Chem. Soc. 2020, 142, 1406-1416)

At Northwest University, researchers have shown that microfibers can form in conjunction with DNA and peptides self-assembling. DNA and peptides operate at the nano level, so when considering the size differences, microfibers are huge. (Freeman et al., Science, 2018, 362, 808-813)

At Ben-Gurion University of the Negev, scientists have used hybrid molecules to create an onion-like spherical structure containing cancer medication, which holds promise to be used in the body to target cancerous tumors. (Chotera et al., Chem. Eur. J., 2018, 24, 10128-10135)

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Scientists discover the highest energy gamma-rays ever from a pulsar

Scientists using the H.E.S.S. observatory in Namibia have detected the highest energy gamma rays ever from a dead star called a pulsar. The energy of these gamma rays clocked in at 20 tera-electronvolts, or about ten trillion times the energy of visible light. This observation is hard to reconcile with the theory of the production of such pulsed gamma rays, as the international team reports in the journal Nature Astronomy.

Pulsars are the left-over corpses of stars that spectacularly exploded in a supernova. The explosions leave behind a tiny, dead star with a diameter of just some 20 kilometres, rotating extremely fast and endowed with an enormous magnetic field. "These dead stars are almost entirely made up of neutrons and are incredibly dense: a teaspoon of their material has a mass of more than five billion tonnes, or about 900 times the mass of the Great Pyramid of Giza," explains H.E.S.S. scientist Emma de Oña Wilhelmi, a co-author of the publication working at DESY.

Pulsars emit rotating beams of electromagnetic radiation, somewhat like cosmic lighthouses. If their beam sweeps across our solar system, we see flashes of radiation at regular time intervals. These flashes, also called pulses of radiation, can be searched for in different energy bands of the electromagnetic spectrum. Scientists think that the source of this radiation are fast electrons produced and accelerated in the pulsar's magnetosphere, while traveling towards its periphery. The magnetosphere is made up of plasma and electromagnetic fields that surround and co-rotate with the star. "On their outward journey, the electrons acquire energy and release it in the form of the observed radiation beams," says Bronek Rudak from the Nicolaus Copernicus Astronomical Center (CAMK PAN) in Poland, also a co-author.

The Vela pulsar, located in the Southern sky in the constellation Vela (sail of the ship), is the brightest pulsar in the radio band of the electromagnetic spectrum and the brightest persistent source of cosmic gamma rays in the giga-electronvolts (GeV) range. It rotates about eleven times per second. However, above a few GeV, its radiation ends abruptly, presumably because the electrons reach the end of the pulsar's magnetosphere and escape from it.

But this is not the end of the story: using deep observations with H.E.S.S., a new radiation component at even higher energies has now been discovered, with energies of up to tens of tera-electronvolts (TeV). "That is about 200 times more energetic than all radiation ever detected before from this object," says co-author Christo Venter from the North-West University in South Africa. This very high-energy component appears at the same phase intervals as the one observed in the GeV range. However, to attain these energies, the electrons might have to travel even farther than the magnetosphere, yet the rotational emission pattern needs to remain intact.

"This result challenges our previous knowledge of pulsars and requires a rethinking of how these natural accelerators work," says Arache Djannati-Atai from the Astroparticle & Cosmology (APC) laboratory in France, who led the research. "The traditional scheme according to which particles are accelerated along magnetic field lines within or slightly outside the magnetosphere cannot sufficiently explain our observations. Perhaps we are witnessing the acceleration of particles through the so-called magnetic reconnection process beyond the light cylinder, which still somehow preserves the rotational pattern? But even this scenario faces difficulties to explain how such extreme radiation is produced."

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And then there were 6 -- kinds of taste, that is

Japanese scientist Kikunae Ikeda first proposed umami as a basic taste -- in addition to sweet, sour, salty and bitter -- in the early 1900s. About eight decades later, the scientific community officially agreed with him.

Now, scientists led by researchers at the USC Dornsife College of Letters, Arts and Sciences have evidence of a sixth basic taste.

In research published Oct. 10 in Nature Communications, USC Dornsife neuroscientist Emily Liman and her team found that the tongue responds to ammonium chloride through the same protein receptor that signals sour taste.

"If you live in a Scandinavian country, you will be familiar with and may like this taste," says Liman, professor of biological sciences. In some northern European countries, salt licorice has been a popular candy at least since the early 20th century. The treat counts among its ingredients salmiak salt, or ammonium chloride.

Scientists have for decades recognized that the tongue responds strongly to ammonium chloride. However, despite extensive research, the specific tongue receptors that react to it remained elusive.

Liman and the research team thought they might have an answer.

In recent years, they uncovered the protein responsible for detecting sour taste. That protein, called OTOP1, sits within cell membranes and forms a channel for hydrogen ions moving into the cell.

Hydrogen ions are the key component of acids, and as foodies everywhere know, the tongue senses acid as sour. That's why lemonade (rich in citric and ascorbic acids), vinegar (acetic acid) and other acidic foods impart a zing of tartness when they hit the tongue. Hydrogen ions from these acidic substances move into taste receptor cells through the OTOP1 channel.

Because ammonium chloride can affect the concentration of acid -- that is, hydrogen ions -- within a cell, the team wondered if it could somehow trigger OTOP1.

To answer this question, they introduced the Otop1 gene into lab-grown human cells so the cells produce the OTOP1 receptor protein. They then exposed the cells to acid or to ammonium chloride and measured the responses.

"We saw that ammonium chloride is a really strong activator of the OTOP1 channel," Liman said. "It activates as well or better than acids."

Ammonium chloride gives off small amounts of ammonia, which moves inside the cell and raises the pH, making it more alkaline, which means fewer hydrogen ions.

"This pH difference drives a proton influx through the OTOP1 channel," explained Ziyu Liang, a PhD student in Liman's lab and first author on the study.

To confirm that their result was more than a laboratory artifact, they turned to a technique that measures electrical conductivity, simulating how nerves conduct a signal. Using taste bud cells from normal mice and from mice the lab previously genetically engineered to not produce OTOP1, they measured how well the taste cells generated electrical responses called action potentials when ammonium chloride is introduced.

Taste bud cells from wildtype mice showed a sharp increase in action potentials after ammonium chloride was added while taste bud cells from the mice lacking OTOP1 failed to respond to the salt. This confirmed their hypothesis that OTOP1 responds to the salt, generating an electrical signal in taste bud cells.

The same was true when another member of the research team, Courtney Wilson, recorded signals from the nerves that innervate the taste cells. She saw the nerves respond to addition of ammonium chloride in normal mice but not in mice lacking OTOP1.

Then the team went one step further and examined how mice react when given a choice to drink either plain water or water laced with ammonium chloride. For these experiments, they disabled the bitter cells that also contribute to the taste of ammonium chloride. Mice with a functional OTOP1 protein found the taste of ammonium chloride unappealing and did not drink the solution, while mice lacking the OTOP1 protein did not mind the alkaline salt, even at very high concentrations.

"This was really the clincher," Liman said. "It shows that the OTOP1 channel is essential for the behavioral response to ammonium."

But the scientists weren't done. They wondered if other animals would also be sensitive to and use their OTOP1 channels to detect ammonium. They found that the OTOP1 channel in some species seems to be more sensitive to ammonium chloride than in other species. And human OTOP1 channels were also sensitive to ammonium chloride.

So, what is the advantage in tasting ammonium chloride and why is it evolutionarily so conserved?

Liman speculates that the ability to taste ammonium chloride might have evolved to help organisms avoid eating harmful biological substances that have high concentrations of ammonium.

"Ammonium is found in waste products -- think of fertilizer -- and is somewhat toxic," she explained, "so it makes sense we evolved taste mechanisms to detect it. Chicken OTOP1 is much more sensitive to ammonium than zebra fish." Liman speculates that these variations may reflect differences in the ecological niches of different animals. "Fish may simply not encounter much ammonium in the water, while chicken coops are filled with ammonium that needs to be avoided and not eaten."

But she cautions that this is very early research and further study is needed to understand species differences in sensitivity to ammonium and what makes OTOP1 channels from some species sensitive and some less sensitive to ammonium.

Towards this end, they have made a start. "We identified a particular part of the OTOP1 channel -- a specific amino acid -- that's necessary for it to respond to ammonium," Liman said. "If we mutate this one residue, the channel is not nearly as sensitive to ammonium, but it still responds to acid."

Moreover, because this one amino acid is conserved across different species, there must have been selective pressure to maintain it, she says. In other words, the OTOP1 channel's ability to respond to ammonium must have been important to the animals' survival.

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Oldest fossil human footprints in North America confirmed

The 2021 results began a global conversation that sparked public imagination and incited dissenting commentary throughout the scientific community as to the accuracy of the ages.

"The immediate reaction in some circles of the archeological community was that the accuracy of our dating was insufficient to make the extraordinary claim that humans were present in North America during the Last Glacial Maximum. But our targeted methodology in this current research really paid off," said Jeff Pigati, USGS research geologist and co-lead author of a newly published study that confirms the age of the White Sands footprints.

The controversy centered on the accuracy of the original ages, which were obtained by radiocarbon dating. The age of the White Sands footprints was initially determined by dating seeds of the common aquatic plant Ruppia cirrhosa that were found in the fossilized impressions. But aquatic plants can acquire carbon from dissolved carbon atoms in the water rather than ambient air, which can potentially cause the measured ages to be too old.

"Even as the original work was being published, we were forging ahead to test our results with multiple lines of evidence," said Kathleen Springer, USGS research geologist and co-lead author on the current Science paper. "We were confident in our original ages, as well as the strong geologic, hydrologic, and stratigraphic evidence, but we knew that independent chronologic control was critical."

For their follow-up study, the researchers focused on radiocarbon dating of conifer pollen, because it comes from terrestrial plants and therefore avoids potential issues that arise when dating aquatic plants like Ruppia. The researchers used painstaking procedures to isolate approximately 75,000 pollen grains for each sample they dated. Importantly, the pollen samples were collected from the exact same layers as the original seeds, so a direct comparison could be made. In each case, the pollen age was statistically identical to the corresponding seed age.

"Pollen samples also helped us understand the broader environmental context at the time the footprints were made," said David Wahl, USGS research geographer and a co-author on the current Science article. "The pollen in the samples came from plants typically found in cold and wet glacial conditions, in stark contrast with pollen from the modern playa which reflects the desert vegetation found there today."

In addition to the pollen samples, the team used a different type of dating called optically stimulated luminescence, which dates the last time quartz grains were exposed to sunlight. Using this method, they found that quartz samples collected within the footprint-bearing layers had a minimum age of ~21,500 years, providing further support to the radiocarbon results.

With three separate lines of evidence pointing to the same approximate age, it is highly unlikely that they are all incorrect or biased and, taken together, provide strong support for the 21,000 to 23,000-year age range for the footprints.

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