Salmonella exposure a risk for colon cancer

A new study published in the journal Cell Reports Medicine links exposure to salmonella bacteria to colon cancer risk.

The researchers, including a team led by Jun Sun from the University of Illinois Chicago, studied human colon cancer tissue samples and animal models and found that exposure to salmonella was linked with colon cancers that developed earlier and grew larger.

The study authors first looked at data from a Netherlands-based retrospective study of colon cancer patients that found tissue samples taken during routine colon cancer surgery with salmonella antibodies tended to be from people who had worse colon cancer outcomes.

Using salmonella strains isolated from these tissue samples, Sun and her U.S.-based team studied mice with colon cancer that had been exposed to the bacteria. They observed accelerated tumor growth and larger tumors in mice with salmonella exposure. They also saw that there was increased salmonella translocated to the tumors.

"During infection, salmonella hijacks essential host signaling pathways, and these molecular manipulations may cause oncogenic transformation. The current study tells us that more research is needed into the connection between salmonella exposure and colon cancer risk in the USA, and that simply by practicing safe food preparation, we can potentially help to protect ourselves," said Sun, UIC professor of medicine.

Sun's collaborators in the Netherlands also studied the bacteria in vitro. They combined human cancer cells and pre-cancer cells with the salmonella strain in the lab and measured any growth or changes in the tumor. They saw that even one infection caused transformation and that each salmonella infection exponentially increased the rate of cell transformation.

"The mouse and tissue culture experiments show that salmonella infection had a chronic effect to accelerate tumor growth," said Sun, who also is a member of the University of Illinois Cancer Center at UIC. "This evidence tells us that we need to look closer at salmonella exposure as an environmental risk factor for chronic diseases, such as colon cancer."

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Climate change likely to uproot more Amazon trees

Tropical forests are crucial for sucking up carbon dioxide from the atmosphere. But they're also subject to intense storms that can cause "windthrow" -- the uprooting or breaking of trees. These downed trees decompose, potentially turning a forest from a carbon sink into a carbon source.

A new study finds that more extreme thunderstorms from climate change will likely cause a greater number of large windthrow events in the Amazon rainforest. This is one of the few ways that researchers have developed a link between storm conditions in the atmosphere and forest mortality on land, helping fill a major gap in models.

"Building this link between atmospheric dynamics and damage at the surface is very important across the board," said Jeff Chambers, a senior faculty scientist at the Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab), and director of the Next Generation Ecosystem Experiments (NGEE)-Tropics project, which performed the research. "It's not just for the tropics. It's high-latitude, low-latitude, temperate-latitude, here in the U.S."

Researchers found that the Amazon will likely experience 43% more large blowdown events (of 25,000 square meters or more) by the end of the century. The area of the Amazon likely to see extreme storms that trigger large windthrows will also increase by about 50%. The study was published in the journal Nature Communications on Jan. 6.

"We want to know what these extreme storms and windthrows mean in terms of the carbon budget and carbon dynamics, and for carbon sinks in the forests," Chambers said. While downed trees slowly release carbon as they decompose, the open forest becomes host to new plants that pull carbon dioxide from the air. "It's a complicated system, and there are still a lot of pieces of the puzzle that we're working on. In order to answer the question more quantitatively, we need to build out the land-atmosphere links in Earth system models."

To find the link between air and land, researchers compared a map of more than 1,000 large windthrows with atmospheric data. They found that a measurement known as CAPE, the "convective available potential energy," was a good predictor of major blowdowns. CAPE measures the amount of energy available to move parcels of air vertically, and a high value of CAPE often leads to thunderstorms. More extreme storms can come with intense vertical winds, heavy rains or hail, and lightning, which interact with trees from the canopy down to the soil.

"Storms account for over half of the forest mortality in the Amazon," said Yanlei Feng, first author on the paper. "Climate change has a lot of impact on Amazon forests, but so far, a large fraction of the research focus has been on drought and fire. We hope our research brings more attention to extreme storms and improves our models to work under a changing environment from climate change."

While this study looked at a future with high carbon emissions (a scenario known as SSP-585), scientists could use projected CAPE data to explore windthrow impacts in different emissions scenarios. Researchers are now working to integrate the new forest-storm relationship into Earth system models. Better models will help scientists explore how forests will respond to a warmer future -- and whether they can continue to siphon carbon out of the atmosphere or will instead become a contributor.

"This was a very impactful climate change study for me," said Feng, who completed the research as a graduate student researcher in the NGEE-Tropics project at Berkeley Lab. She now studies carbon capture and storage at the Carnegie Institution for Science at Stanford University. "I'm worried about the projected increase in forest disturbances in our study and I hope I can help limit climate change. So now I'm working on climate change solutions."

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Vitamin D benefits and metabolism may depend on body weight

Researchers from Brigham and Women's Hospital, a founding member of the Mass General Brigham healthcare system, have found new evidence that vitamin D may be metabolized differently in people with an elevated body mass index (BMI). The study, appearing in JAMA Network Open, is a new analysis of data from the VITAL trial, a large nationwide clinical trial led by Brigham researchers that investigated whether taking vitamin D or marine omega-3 supplements could reduce the risk of developing cancer, heart disease, or stroke.

"The analysis of the original VITAL data found that vitamin D supplementation correlated with positive effects on several health outcomes, but only among people with a BMI under 25," said first author Deirdre K. Tobias, ScD, an associate epidemiologist in Brigham's Division of Preventive Medicine. "There seems to be something different happening with vitamin D metabolism at higher body weights, and this study may help explain diminished outcomes of supplementation for individuals with an elevated BMI."

Vitamin D is an essential nutrient involved in many biological processes, most notably helping our body absorb minerals, such as calcium and magnesium. While some of the vitamin D we need is made in the body from sunlight, vitamin D deficiencies are often treated with supplementation. Evidence from laboratory studies, epidemiologic research and clinical research has also suggested that vitamin D may play a role in the incidence and progression of cancer and cardiovascular disease, and it was this evidence that prompted the original VITAL trial.

The VITAL trial was a randomized, double-blind, placebo-controlled trial in 25,871 U.S. participants, which included men over the age of 50 and women over the age of 55. All participants were free of cancer and cardiovascular disease at the time of enrollment. While the trial found little benefit of vitamin D supplementation for preventing cancer, heart attack, or stroke in the overall cohort, there was a statistical correlation between BMI and cancer incidence, cancer mortality, and autoimmune disease incidence. Other studies suggest similar results for type 2 diabetes.

The new study aimed to investigate this correlation. The researchers analyzed data from 16,515 participants from the original trial who provided blood samples at baseline (before randomization to vitamin D), as well as 2,742 with a follow-up blood sample taken after two years. The researchers measured the levels of total and free vitamin D, as well as many other novel biomarkers for vitamin D, such as its metabolites, calcium, and parathyroid hormone, which helps the body utilize vitamin D.

"Most studies like this focus on the total vitamin D blood level," said senior author JoAnn E. Manson, MD, DrPH, chief of the Division of Preventive Medicine at the Brigham and principal investigator of VITAL. "The fact that we were able to look at this expanded profile of vitamin D metabolites and novel biomarkers gave us unique insights into vitamin D availability and activity, and whether vitamin D metabolism might be disrupted in some people but not in others."

The researchers found that vitamin D supplementation increased most of the biomarkers associated with vitamin D metabolism in people, regardless of their weight. However, these increases were significantly smaller in people with elevated BMIs.

"We observed striking differences after two years, indicating a blunted response to vitamin D supplementation with higher BMI," Tobias said. "This may have implications clinically and potentially explain some of the observed differences in the effectiveness of vitamin D supplementation by obesity status."

"This study sheds light on why we're seeing 30-40 percent reductions in cancer deaths, autoimmune diseases, and other outcomes with vitamin D supplementation among those with lower BMIs but minimal benefit in those with higher BMIs, suggesting it may be possible to achieve benefits across the population with more personalized dosing of vitamin D," said Manson. "These nuances make it clear that there's more to the vitamin D story."

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A star's unexpected survival

Hundreds of millions of light-years away in a distant galaxy, a star orbiting a supermassive black hole is being violently ripped apart under the black hole's immense gravitational pull. As the star is shredded, its remnants are transformed into a stream of debris that rains back down onto the black hole to form a very hot, very bright disk of material swirling around the black hole, called an accretion disc. This phenomenon -- where a star is destroyed by a supermassive black hole and fuels a luminous accretion flare -- is known as a tidal disruption event (TDE), and it is predicted that TDEs occur roughly once every 10,000 to 100,000 years in a given galaxy.

With luminosities exceeding entire galaxies (i.e., billions of times brighter than our Sun) for brief periods of time (months to years), accretion events enable astrophysicists to study supermassive black holes (SMBHs) from cosmological distances, providing a window into the central regions of otherwise-quiescent -- or dormant -- galaxies. By probing these ``strong-gravity'' events, where Einstein's general theory of relativity is critical for determining how matter behaves, TDEs yield information about one of the most extreme environments in the universe: the event horizon -- the point of no return -- of a black hole.

TDEs are usually "once-and-done" because the extreme gravitational field of the SMBH destroys the star, meaning that the SMBH fades back into darkness following the accretion flare. In some instances, however, the high-density core of the star can survive the gravitational interaction with the SMBH, allowing it to orbit the black hole more than once. Researchers call this a repeating partial TDE.

A team of physicists, including lead author Thomas Wevers, Fellow of the European Southern Observatory, and co-authors Eric Coughlin, assistant professor of physics at Syracuse University, and Dheeraj R. "DJ" Pasham, research scientist at MIT's Kavli Institute for Astrophysics and Space Research, have proposed a model for a repeating partial TDE. Their findings, published in Astrophysical Journal Letters, describe the capture of the star by a SMBH, the stripping of the material each time the star comes close to the black hole, and the delay between when the material is stripped and when it feeds the black hole again. The team's work is the first to develop and use a detailed model of a repeating partial TDE to explain the observations, make predictions about the orbital properties of a star in a distant galaxy, and understand the partial tidal disruption process.

The team is studying a TDE known as AT2018fyk (AT stands for ``Astrophysical Transient''). The star was captured by a SMBH through an exchange process known as "Hills capture," where the star was originally part of a binary system (two stars that orbit one another under their mutual gravitational attraction) that was ripped apart by the gravitational field of the black hole. The other (non-captured) star was ejected from the center of the galaxy at speeds comparable to ~ 1000 km/s, which is known as a hypervelocity star.

Once bound to the SMBH, the star powering the emission from AT2018fyk has been repeatedly stripped of its outer envelope each time it passes through its point of closest approach with the black hole. The stripped outer layers of the star form the bright accretion disk, which researchers can study using X-Ray and Ultraviolet /Optical telescopes that observe light from distant galaxies.

According to Wevers, having the opportunity to study a partial TDE gives unprecedented insight into the existence of supermassive black holes and the orbital dynamics of stars in the centers of galaxies.

"Until now, the assumption has been that when we see the aftermath of a close encounter between a star and a supermassive black hole, the outcome will be fatal for the star, that is, the star is completely destroyed," he says. "But contrary to all other TDEs we know of, when we pointed our telescopes to the same location again several years later, we found that it had re-brightened again. This led us to propose that rather than being fatal, part of the star survived the initial encounter and returned to the same location to be stripped of material once more, explaining the re-brightening phase."

First detected in 2018, AT2018fyk was initially perceived as an ordinary TDE. For approximately 600 days the source stayed bright in the X-ray, but then abruptly went dark and was undetectable -- a result of the stellar remnant core returning to a black hole, explains MIT physicist Dheeraj R. Pasham.

"When the core returns to the black hole it essentially steals all the gas away from the black hole via gravity and as a result there is no matter to accrete and hence the system goes dark," Pasham says.

It wasn't immediately clear what caused the precipitous decline in the luminosity of AT2018fyk, because TDEs normally decay smoothly and gradually -- not abruptly -- in their emission. But around 600 days after the drop, the source was again found to be X-ray bright. This led the researchers to propose that the star survived its close encounter with the SMBH the first time and was in orbit about the black hole.

Using detailed modeling, the team's findings suggest that the orbital period of the star about the black hole is roughly 1,200 days, and it takes approximately 600 days for the material that is shed from the star to return to the black hole and start accreting. Their model also constrained the size of the captured star, which they believe was about the size of the sun. As for the original binary, the team believes the two stars were extremely close to one another before being ripped apart by the black hole, likely orbiting each other every few days.

So how could a star survive its brush with death? It all comes down to a matter of proximity and trajectory. If the star collided head-on with the black hole and passed the event horizon -- the threshold where the speed needed to escape the black hole surpasses the speed of light -- the star would be consumed by the black hole. If the star passed very close to the black hole and crossed the so-called "tidal radius" -- where the tidal force of the hole is stronger than the gravitational force that keeps the star together -- it would be destroyed. In the model they have proposed, the star's orbit reaches a point of closest approach that is just outside of the tidal radius, but doesn't cross it completely: some of the material at the stellar surface is stripped by the black hole, but the material at its center remains intact.

How, or if, the process of the star orbiting the SMBH can occur over many repeated passages is a theoretical question that the team plans to investigate with future simulations. Syracuse physicist Eric Coughlin explains that they estimate between 1 to 10% of the mass of the star is lost each time it passes the black hole, with the large range due to uncertainty in modeling the emission from the TDE.

"If the mass loss is only at the 1% level, then we expect the star to survive for many more encounters, whereas if it is closer to 10%, the star may have already been destroyed," notes Coughlin.

The team will keep their eyes to the sky in the coming years to test their predictions. Based on their model, they forecast that the source will abruptly disappear around March 2023 and brighten again when the freshly stripped material accretes onto the black hole in 2025.

The team says their study offers a new way forward for tracking and monitoring follow-up sources that have been detected in the past. The work also suggests a new paradigm for the origin of repeating flares from the centers of external galaxies.

"In the future, it is likely that more systems will be checked for late-time flares, especially now that this project puts forth a theoretical picture of the capture of the star through a dynamical exchange process and the ensuing repeated partial tidal disruption," says Coughlin. "We're hopeful this model can be used to infer the properties of distant supermassive black holes and gain an understanding of their "demographics," being the number of black holes within a given mass range, which is otherwise difficult to achieve directly."

The team says the model also makes several testable predictions about the tidal disruption process, and with more observations of systems like AT2018fyk, it should give insight into the physics of partial tidal disruption events and the extreme environments around supermassive black holes.

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20,000 premature US deaths caused by human-ignited fires each year

Over 80% of premature deaths caused by small smoke particles in the United States result directly from human-ignited fires. This is the outcome of a study published today in IOP Publishing's journal Environmental Research Letters.

The new study, led by researchers at the Massachusetts Institute of Technology, analyses the impact of smoke particles on air quality in the United States. Their research shows that human-ignited fires account for more than 67% of small smoke particles called PM2.5 in the United States. These particles are known to degrade air quality, causing respiratory illnesses and premature death.

The level of fire activity in the US is on the rise. The research team estimate that smoke from human-ignited fires was responsible for 20,000 premature deaths in 2018 alone, a year with a high frequency of fire events -- a substantial portion of which were associated with human ignitions such as agricultural and human lit fires. This is 270% more than there were in 2003, when there was a low frequency of fire events. The research highlights that during high fire activity years, there are much higher concentrations of smoke PM2.5 in the air.

Dr Therese Carter, lead author of the study, said: "Fires not only threaten human lives, infrastructure, and ecosystems, but they are also a major cause for concern in terms of air quality. High levels of smoke exposure can negatively impact human health resulting in conditions such as respiratory infections, lung cancer, heart disease and even premature births. Our results show that a large and significant portion of harmful smoke particles result directly from human-lit fires."

The team used the Global Fire Emissions Database to quantify agricultural fire emissions, then classify these fires into two categories: human vs. natural ignition. Applying a chemical transport model, they simulate the concentration of smoke particles across the United States, concluding that a significant portion of PM2.5 in the US results from human-ignited fires and thus has the potential to be managed.

To limit the devastating effects of pollution from small smoke particles, the team recommends an ignition-focused approach. State agencies can implement management plans to restrict the ignition of agricultural fires to periods when weather conditions would minimise health impacts. However, human-ignited wildfires are much harder to manage due to their sporadic and unplanned nature.

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NASA says 2022 fifth warmest year on record, warming trend continues

Earth's average surface temperature in 2022 tied with 2015 as the fifth warmest on record, according to an analysis by NASA. Continuing the planet's long-term warming trend, global temperatures in 2022 were 1.6 degrees Fahrenheit (0.89 degrees Celsius) above the average for NASA's baseline period (1951-1980), scientists from NASA's Goddard Institute for Space Studies (GISS) in New York reported.

"This warming trend is alarming," said NASA Administrator Bill Nelson. "Our warming climate is already making a mark: Forest fires are intensifying; hurricanes are getting stronger; droughts are wreaking havoc and sea levels are rising. NASA is deepening our commitment to do our part in addressing climate change. Our Earth System Observatory will provide state-of-the-art data to support our climate modeling, analysis and predictions to help humanity confront our planet's changing climate."

The past nine years have been the warmest years since modern recordkeeping began in 1880. This means Earth in 2022 was about 2 degrees Fahrenheit (or about 1.11 degrees Celsius) warmer than the late 19th century average.

"The reason for the warming trend is that human activities continue to pump enormous amounts of greenhouse gases into the atmosphere, and the long-term planetary impacts will also continue," said Gavin Schmidt, director of GISS, NASA's leading center for climate modeling.

Human-driven greenhouse gas emissions have rebounded following a short-lived dip in 2020 due to the COVID-19 pandemic. Recently, NASA scientists, as well as international scientists, determined carbon dioxide emissions were the highest on record in 2022. NASA also identified some super-emitters of methane -- another powerful greenhouse gas -- using the Earth Surface Mineral Dust Source Investigation instrument that launched to the International Space Station last year.

The Arctic region continues to experience the strongest warming trends -- close to four times the global average -- according to GISS research presented at the 2022 annual meeting of the American Geophysical Union, as well as a separate study.

Communities around the world are experiencing impacts scientists see as connected to the warming atmosphere and ocean. Climate change has intensified rainfall and tropical storms, deepened the severity of droughts, and increased the impact of storm surges. Last year brought torrential monsoon rains that devastated Pakistan and a persistent megadrought in the U.S. Southwest. In September, Hurricane Ian became one of the strongest and costliest hurricanes to strike the continental U.S.

Tracking Our Changing Planet

NASA's global temperature analysis is drawn from data collected by weather stations and Antarctic research stations, as well as instruments mounted on ships and ocean buoys. NASA scientists analyze these measurements to account for uncertainties in the data and to maintain consistent methods for calculating global average surface temperature differences for every year. These ground-based measurements of surface temperature are consistent with satellite data collected since 2002 by the Atmospheric Infrared Sounder on NASA's Aqua satellite and with other estimates.

NASA uses the period from 1951-1980 as a baseline to understand how global temperatures change over time. That baseline includes climate patterns such as La Niña and El Niño, as well as unusually hot or cold years due to other factors, ensuring it encompasses natural variations in Earth's temperature.

Many factors can affect the average temperature in any given year. For example, 2022 was one of the warmest on record despite a third consecutive year of La Niña conditions in the tropical Pacific Ocean. NASA scientists estimate that La Niña's cooling influence may have lowered global temperatures slightly (about 0.11 degrees Fahrenheit or 0.06 degrees Celsius) from what the average would have been under more typical ocean conditions.

A separate, independent analysis by the National Oceanic and Atmospheric Administration (NOAA) concluded that the global surface temperature for 2022 was the sixth highest since 1880. NOAA scientists use much of the same raw temperature data in their analysis and have a different baseline period (1901-2000) and methodology. Although rankings for specific years can differ slightly between the records, they are in broad agreement and both reflect ongoing long-term warming.

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Ten-minute scan enables detection and cure of the commonest cause of high blood pressure

Doctors at Queen Mary University of London and Barts Hospital, and Cambridge University Hospital, have led research using a new type of CT scan to light up tiny nodules in a hormone gland and cure high blood pressure by their removal. The nodules are discovered in one-in-twenty people with high blood pressure.

Published today in Nature Medicine, the research solves a 60-year problem of how to detect the hormone producing nodules without a difficult catheter study that is available in only a handful of hospitals, and often fails. The research also found that, when combined with a urine test, the scan detects a group of patients who come off all their blood pressure medicines after treatment.

128 people participated in the study of a new scan after doctors found that their Hypertension (high blood pressure) was caused by a steroid hormone, aldosterone. The scan found that in two thirds of patients with elevated aldosterone secretion, this is coming from a benign nodule in just one of the adrenal glands, which can then be safely removed. The scan uses a very short-acting dose of metomidate, a radioactive dye that sticks only to the aldosterone-producing nodule. The scan was as accurate as the old catheter test, but quick, painless and technically successful in every patient. Until now, the catheter test was unable to predict which patients would be completely cured of hypertension by surgical removal of the gland. By contrast, the combination of a 'hot nodule' on the scan and urine steroid test detected 18 of the 24 patients who achieved a normal blood pressure off all their drugs.

The research, conducted on patients at Barts Hospital, Cambridge University Hospital, and Guy's and St Thomas's, and Universities of Glasgow and Birmingham, was funded by the National Institute for Health and Care Research (NIHR) and Medical Research Council (MRC) partnership, Barts Charity, and the British Heart Foundation.

Professor Morris Brown, co-senior author of the study and Professor of Endocrine Hypertension at Queen Mary University of London, said: "These aldosterone-producing nodules are very small and easily overlooked on a regular CT scan. When they glow for a few minutes after our injection, they are revealed as the obvious cause of Hypertension, which can often then be cured. Until now, 99% are never diagnosed because of the difficulty and unavailability of tests. Hopefully this is about to change."

Professor William Drake, co-senior author of the study and Professor of Clinical Endocrinology at Queen Mary University of London, said:"This study was the result of years of hard work and collaboration between centres across the UK. Much of the 'on the ground' energy and drive came from the talented research fellows who, in addition to doing this innovative work, gave selflessly of their time and energy during the national pandemic emergency. The future of research in this area is in very safe hands."

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Madagascar mouse lemur retroviruses are diverse and surprisingly similar to ones found in polar bears or domestic sheep

Madagascar is home to a unique biodiversity with a large number of endemic species, among those many lemur species, including the mouse lemurs. This diversity is also found in their retroviruses, a team led by scientists from the Leibniz Institute of Zoo and Wildlife Research (Leibniz-IZW) and the University of Stirling reports in the journal "Virus Evolution." They analysed the mouse lemur genome and identified viruses of two classes that represent ancient infections of the mouse lemur germline. The viruses now behave similarly to lemur genes and are thus called endogenous retroviruses (ERVs). It was surprising that some of the identified retroviruses are closely related to viruses found in other, very different mammals such as polar bears or domestic sheep. This suggests an intriguing and complex pattern of host switching of retroviruses, much more complex than previously thought.

For their analysis, the team collected blood samples from four species of Malagasy mouse lemurs and screened them using high throughput sequencing. The scientists identified two gamma and three beta retrovirus sequences in the lemurs' genomes, representing ancient infections of the mouse lemur germlines. Since then, the virus DNA has been incorporated in the host genomes and the viruses are no longer active or infectious. "We were surprised to find that one of the two identified gamma retroviruses was related to an ERV described in polar bears," states Dr Sharon Kessler, a German Academic Exchange Service (DAAD) supported scientist and Assistant Professor at the University of Stirling. The polar bear virus is young from an evolutionary point of view whereas the lemur virus is old. "How these related viruses infected such geographically separated species is unclear," Kessler says.

There were further surprises among the beta retroviruses. A virulent retrovirus that infects domestic sheep called Jaagsiekte sheep retrovirus (JSRV), which also forms ERVs in domestic sheep, is thought to be a virus confined to domestic sheep, goats and their relatives -- the first cloned sheep "Dolly" had to be euthanised after a JSRV infection and subsequent illness. The mouse lemurs have a closely related JSRV-like virus in their genome. "This suggests that JSRV-like viruses have been more widespread among mammals and are considerably older than previously thought. Why they only show up in such disparate species and in such a punctuated way is curious," says Prof Alex Greenwood, head of the Leibniz-IZW Department of Wildlife Diseases, where the sample screening was conducted. Similarly, the team also identified a virus in the mouse lemurs related to retroviruses found in squirrel monkeys, vampire bats and marsupials. "This group of viruses is becoming more interesting over time as more and more examples of similar viruses are being found in many places including very young ones that may still have currently infectious exogenous counterparts in nature," says Greenwood.

Much of the mouse lemur retroviral diversity observed is associated with non-primate viruses, suggesting a complex pattern of viral host switching around the time the ancestors of lemurs colonized Madagascar. Further studies of viral diversity will help to clarify the complex history of retroviral transmission among mammals.

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Martian meteorite contains large diversity of organic compounds

The Martian meteorite Tissint contains a huge diversity of organic compounds, found an international team of researchers led by Technical University of Munich and Helmholtz Munich's Philippe Schmitt-Kopplin and including Carnegie's Andrew Steele. Their work is published in Science Advances.

Tissint, which crash landed in Morocco more than 11 years ago, is one of only five Martian meteorites that have been observed as they fell to Earth. Pieces of it were found scattered around the desert about 30 miles from the town after which it is named.

This sample of Martian rock was formed hundreds of millions of years ago on our next-door planetary neighbor and was launched into space by a violent event. Unraveling the origin stories of the Tissint meteorite's organic compounds can help scientists understand whether the Red Planet ever hosted life, as well as Earth's geologic history.

"Mars and Earth share many aspects of their evolution," said lead author Schmitt-Kopplin. "And while life arose and thrived on our home planet, the question of whether it ever existed on Mars is a very hot research topic that requires deeper knowledge of our neighboring planet's water, organic molecules, and reactive surfaces."

Organic molecules contain carbon, hydrogen, oxygen, nitrogen, sulfur, and sometimes other elements. Organic compounds are commonly associated with life, although previous Martian meteorite research demonstrated that they can be created by non-biological processes, referred to as abiotic organic chemistry.

"Understanding the processes and sequence of events that shaped this rich organic bounty will reveal new details about Mars' habitability and potentially about the reactions that could lead to the formation of life," added Steele, who has done extensive research on organic material in Martian meteorites, including Tissint, and is a member of both the Perseverance and Curiosity rovers' science teams.

The researchers were able to thoroughly analyze the meteorite's organic inventory, revealing a link between the type and diversity of organic molecules and specific mineralogy. Their efforts resulted in the most comprehensive catalog ever made of the diversity of organic compounds found in a Martian meteorite or in a sample collected and analyzed by a rover. This work uncovered details about how the processes occurring in Mars' mantle and crust evolved, especially with regard to abiotic organics that formed from water-rock interactions.

Of particular interest was the abundance of organic magnesium compounds, a suite of organic molecules not previously seen on Mars, which offer new insights about the high-pressure, high-temperature geochemistry that shaped the Red Planet's deep interior and indicate a connection between its carbon cycle and its mineral evolution.

The researchers say that samples returned from Mars by future missions should provide an unprecedented amount of information about the formation, stability and dynamics of organic compounds in real Martian environments.

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Using paleogenomics to elucidate 10,000 years of immune system evolution

Scientists from the Institut Pasteur, Université Paris Cité, the CNRS and the Collège de France have used paleogenomics to trace 10,000 years of human immune system evolution. They analyzed the genomes of more than 2,800 individuals who lived in Europe over the past ten millennia. They were able to date the increase in frequency of most of the mutations that are advantageous in defending against pathogens to after the Bronze Age, 4,500 years ago. The scientists also observed that mutations conferring a higher risk of developing inflammatory disorders have become more frequent over the past 10,000 years. These enlightening results on the effects of natural selection on immunity genes were published in the journal Cell Genomics on January 13, 2023.

In the 1950s, the geneticist J.B.S. Haldane attributed the maintenance or persistence of the mutation responsible for anomalies in red blood cells commonly observed in Africa to the protection these anomalies provided against malaria, an endemic infection that claims millions of lives. This theory suggested that pathogens are among the strongest selective pressures faced by humans. Several population genetics studies subsequently confirmed the theory. But major questions remained, especially regarding the specific epochs during which the selective pressures exerted by pathogens on human populations were strongest and their impact on the present-day risk of developing inflammatory or autoimmune disorders.

To address these questions, scientists from the Institut Pasteur, Université Paris Cité, the CNRS and the Collège de France, in collaboration with the Imagine Institute and The Rockefeller University (United States), adopted an approach based on paleogenomics. This discipline, which studies the DNA from fossil remains, has led to major discoveries about the history and evolution of humans and human diseases, as illustrated by the decision to award the 2022 Nobel Prize in Physiology or Medicine to the paleogeneticist Svante Pääbo. In the study led by the Institut Pasteur, published on January 13 in the journal Cell Genomics, the scientists analyzed the variability of the genomes of more than 2,800 individuals who lived in Europe over the past ten millennia -- a period covering the Neolithic, the Bronze Age, the Iron Age, the Middle Ages and the present.

By reconstituting the evolution over time of hundreds of thousands of genetic mutations, the scientists initially identified mutations that rapidly increased in frequency in Europe, indicating that they were advantageous. These mutations that evolved under "positive" natural selection are mainly located in 89 genes enriched in functions relating to the innate immune response, including especially the OAS genes -- which are responsible for antiviral activity -- and the gene responsible for the ABO blood group system. Surprisingly, most of these positive selection events, which demonstrate a genetic adaptation to the pathogenic environment, began recently, from the start of the Bronze Age, around 4,500 years ago. The scientists explain this "acceleration" in adaptation by the growth in the human population during this period and/or by strong selective pressures exerted by pathogens in the Bronze Age, probably linked to the spread of severe infectious diseases such as plague.

At the same time, the scientists also looked at the opposite situation, in other words, mutations whose frequency fell significantly over the past ten millennia. These mutations are probably subject to "negative" selection because they increase the risk of disease. They noted that once again, these selection events mainly began in the Bronze Age. Many of these disadvantageous mutations were also located in genes associated with the innate immune response, such as TYK2, LPB, TLR3 and IL23R, and have been confirmed in experimental research to have a deleterious effect in terms of infectious disease risk. The results emphasize the value of adopting an evolutionary approach in research on genetic susceptibility to infectious diseases.

Finally, the scientists explored the theory that the selection exerted by pathogens in the past gave an advantage to alleles conferring resistance to infectious diseases, but that in turn these alleles have increased the present-day risk of autoimmune or inflammatory disorders. They investigated the few thousand mutations known to increase susceptibility firstly to tuberculosis, hepatitis, HIV or COVID-19, and secondly to rheumatoid arthritis, systemic lupus erythematosus or inflammatory bowel disease. By looking at the evolution of these mutations over time, they observed that those associated with an increased risk of inflammatory disorders -- including Crohn's disease -- became more frequent over the past 10,000 years, while the frequency of those associated with a risk of developing infectious diseases decreased. "These results suggest that the risk of inflammatory disorders has increased in Europeans since the Neolithic period because of a positive selection of mutations improving resistance to infectious diseases," explains Lluis Quintana-Murci, director of the study and Head of the Human Evolutionary Genetics Unit (Institut Pasteur/CNRS Evolutionary Genomics, Modeling and Health Unit/Université Paris Cité).

The results of the study, which harnessed the huge potential of paleogenomics, show that natural selection has targeted human immunity genes over the past ten millennia in Europe, especially since the start of the Bronze Age, and contributed to present-day disparities in terms of the risk of infectious and inflammatory diseases.

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