Ultraviolet shines light on origins of the solar system

 By analyzing the oxygen isotopes (varieties of an element that have some extra neutrons) of these refractory inclusions, the research team has determined that the differences in composition between the sun, planets and other solar system materials were inherited from the protosolar molecular cloud that existed even before the solar system. The results of their study have been recently published in Science Advances.

"It has been recently demonstrated that variations in isotopic compositions of many elements in our solar system were inherited from the protosolar molecular cloud," said lead author Alexander Krot, of the University of Hawaii. "Our study reveals that oxygen is not the exception."

Molecular cloud or solar nebula?

When scientists compare oxygen isotopes 16, 17 and 18, they observe significant differences between the Earth and the sun. This is believed to be due to processing by ultraviolet light of carbon monoxide, which is broken apart leading to a large change in oxygen isotope ratios in water. The planets are formed from dust that inherits the changed oxygen isotope ratios through interactions with water.

What scientists have not known is whether the ultraviolet processing occurred in the parent molecular cloud that collapsed to form the proto-solar system or later in the cloud of gas and dust from which the planets formed, called the solar nebula.

To determine this, the research team turned to the most ancient component of meteorites, called calcium-aluminum inclusions (CAIs). They used an ion microprobe, electron backscatter images and X-ray elemental analyses at the University of Hawaii's Institute of Geophysics and Planetology to carefully analyze the CAIs. They then incorporated a second isotope system (aluminum and magnesium isotopes) to constrain the age of the CAIs, making the connection -- for the first time -- between oxygen isotope abundances and mass 26 aluminum isotopes.

From these aluminum and magnesium isotopes, they concluded that the CAIs were formed about 10,000 to 20,000 years after the collapse of the parent molecular cloud.

"This is extremely early in the history of the solar system," said Lyons, who is an associate research professor at ASU's School of Earth and Space Exploration, "so early that there would not be enough time to alter oxygen isotopes in the solar nebula."

Although more measurements and modeling work are needed to fully assess the implications of these findings, they do have implications for the inventory of organic compounds available during solar system and later planet and asteroid formation.

Read more at Science Daily

CRISPR meets Pac-Man: New DNA cut-and-paste tool enables bigger gene edits

 Gene editing for the development of new treatments, and for studying disease as well as normal function in humans and other organisms, may advance more quickly with a new tool for cutting larger pieces of DNA out of a cell's genome, according to a new study by UC San Francisco scientists.

Publication of the UCSF study on Oct. 19, 2020 in the journal Nature Methods comes less than two weeks after two researchers who first used the genetic scissors known as CRISPR-Cas9 were selected to receive this year's Nobel Prize in Chemistry.

Though now employed as a research tool in laboratories around the world, CRISPR evolved eons ago in bacteria as a means to fight their ancient nemeses, a whole host of viruses known as bacteriophages. When bacteria encounter a phage, they incorporate a bit of the viral DNA into their own DNA, and it then serves as a template to make RNA that binds to the corresponding viral DNA in the phage itself. The CRISPR enzymes then target, disable and kill the phage.

In his latest work exploring this ancient and strange arms race, principal investigator Joseph Bondy-Denomy, PhD, associate professor in the UCSF Department of Microbiology and Immunology, joined scientists Bálint Csörg?, PhD, and Lina León to develop and test a new CRISPR tool.

The already renowned CRISPR-Cas9 ensemble is like a molecular chisel that can be used to rapidly and precisely excise a small bit of DNA at a targeted site. Other methods can then be used to insert new DNA. But the new CRISPR-Cas3 system adapted by the UCSF scientists employs a different bacterial immune system. The key enzyme in this system, Cas3, acts more like a molecular wood chipper to remove much longer stretches of DNA quickly and accurately.

"Cas3 is like Cas9 with a motor -- after finding its specific DNA target, it runs on DNA and chews it up like a Pac-Man," Bondy-Denomy said.

This new capability to delete or replace long stretches of DNA will enable researchers to more efficiently assess the importance of genomic regions that contain DNA sequences of indeterminate function, according to Bondy-Denomy, an important consideration in understanding humans and the pathogens that plague them.

"Previously, there was no easy and reliable way to delete very large regions of DNA in bacteria for research or therapeutic purposes," he said. "Now, instead of making 100 different small DNA deletions we can just make one deletion and ask, 'What changed?'"

Because bacteria and other types of cells are commonly used to produce small molecule or protein-based pharmaceuticals, CRISPR-Cas3 will enable biotechnology industry scientists to more easily remove potentially pathogenic or useless DNA from these cells, according to Bondy-Denomy.

"Large swathes of bacterial DNA are poorly understood, with unknown functions that in some cases are not necessary for survival," Bondy-Denomy said. "In addition, bacterial DNA contains large stretches of DNA imported from other sources, which can cause disease in the bacterium's human host, or divert bacterial metabolism."

CRISPR-Cas3 also should also allow entire genes to be inserted into the genome in industrial, agricultural or even in human gene therapy applications, Bondy-Denomy said.

The UCSF researchers selected and modified the CRISPR-Cas3 system used by the bacterium Pseudomonas aeruginosa, and demonstrated in this species and in three others, including bacteria that cause disease in humans and plants, that their more compact version functions well to remove selected DNA in all four species. Other CRISPR-Cas3 systems have been made to work in human and other mammalian cells, and that also should be achievable for the modified P. aeruginosa system, Bondy-Denomy said.

Bondy-Denomy studies a range of bacteria, bacteriophage, and CRISPR systems to learn more about how they work and to find useful molecular tools. "CRISPR-Cas3 is by far the most common CRISPR system in nature," he said. "About 10 times as many bacterial species use a Cas3 system as use a Cas9 system. It may be that Cas3 is a better bacterial immune system because it shreds phage DNA."

Unlike Cas9, when Cas3 binds to its precise DNA target it begins chewing up one strand of the double-stranded DNA in both directions, leaving a single strand exposed. The deletions obtained in the UCSF experiments ranged in size, in many cases encompassing as many as 100 bacterial genes. The CRISPR-Cas3 mechanism should also allow for easier replacement of deleted DNA with a new DNA sequence, the researchers found.

For DNA deletion and editing in the lab, scientists program CRISPR systems to target specific DNA in the genome of an organism of interest using any guide sequence they choose.

In the new CRISPR-Cas3 study, by manipulating the sequences of DNA provided to the bacteria for repairing the deletions, the researchers were able to precisely set the boundaries of these large DNA repairs, something they were unable to accomplish with CRISPR-Cas9.

Read more at Science Daily

Study shows active older adults have better physical and mental health

 Older adults with higher physical activity and lower sitting time have better overall physical and mental health, according to a new study from the American Cancer Society (ACS). The study, appearing in the journal, CANCER, suggests that higher amounts of regular moderate- to vigorous-intensity physical activity (MVPA) and lower duration of sedentary time is associated with higher global mental and physical health for older cancer survivors and older adults, in general.

With a rapidly aging population and nearly 16.9 million cancer survivors in the United States today, there is a need to identify strategies associated with healthy aging and improving quality of life for aging cancer survivors. Being physically active is related to several health benefits, and in this study, ACS investigators led by Dr. Erika Rees-Punia analyzed self-reported aerobic and muscle-strengthening physical activities, sitting time, and mental and physical health among nearly 78,000 participants in the ACS's Cancer Prevention Study II Nutrition Cohort. Participants (average age 78 years) included older cancer survivors up to 10 years post-diagnosis, and cancer-free adults.

The investigators found that regardless of cancer history, the differences in global mental and physical health between the most and least active, and the least and most sedentary, were clinically meaningful. These findings provide evidence for the importance of engaging in regular MVPA and decreasing sitting time as a reasonable non-pharmacologic strategy to improve quality of life in older men and women, with or without a prior cancer diagnosis. In fact, the recently published ACS physical activity guidelines recommend that adults get 150-300 minutes of moderate-intensity activity or 75-150 minutes of vigorous-intensity activity through the week, and to limit sedentary behaviors such as screen-based entertainment.

"The findings reinforce the importance of moving more and sitting less for both physical and mental health, no matter your age or history of cancer," said Rees-Punia. "This is especially relevant now as so many of us, particularly cancer survivors, may be staying home to avoid COVID-19 exposure, and may be feeling a little isolated or down. A simple walk or other physical activity that you enjoy may be good for your mind and body."

From Science Daily

Targeting the shell of the Ebola virus

 As the world grapples with the coronavirus (COVID-19) pandemic, another virus has been raging again in the Democratic Republic of the Congo in recent months: Ebola. Since the first terrifying outbreak in 2013, the Ebola virus has periodically emerged in Africa, causing horrific bleeding in its victims and, in many cases, death.

How can we battle these infectious agents that reproduce by hijacking cells and reprogramming them into virus-replicating machines? Science at the molecular level is critical to gaining the upper hand -- research you'll find underway in the laboratory of Professor Juan Perilla at the University of Delaware.

Perilla and his team of graduate and undergraduate students in UD's Department of Chemistry and Biochemistry are using supercomputers to simulate the inner workings of Ebola, observing the way molecules move, atom by atom, to carry out their functions. In the team's latest work, they reveal structural features of the virus's coiled protein shell, or nucleocapsid, that may be promising therapeutic targets, more easily destabilized and knocked out by an antiviral treatment.

The research is highlighted in the Tuesday, Oct. 20 issue of the Journal of Chemical Physics, which is published by the American Institute of Physics, a federation of societies in the physical sciences representing more than 120,000 members.

"The Ebola nucleocapsid looks like a Slinky walking spring, whose neighboring rings are connected," Perilla said. "We tried to find what factors control the stability of this spring in our computer simulations."

The life cycle of Ebola is highly dependent on this coiled nucleocapsid, which surrounds the virus's genetic material consisting of a single strand of ribonucleic acid (ssRNA). Nucleoproteins protect this RNA from being recognized by cellular defense mechanisms. Through interactions with different viral proteins, such as VP24 and VP30, these nucleoproteins form a minimal functional unit -- a copy machine -- for viral transcription and replication.

While nucleoproteins are important to the nucleocapsid's stability, the team's most surprising finding, Perilla said, is that in the absence of single-stranded RNA, the nucleocapsid quickly becomes disordered. But RNA alone is not sufficient to stabilize it. The team also observed charged ions binding to the nucleocapsid, which may reveal where other important cellular factors bind and stabilize the structure during the virus's life cycle.

Perilla compared the team's work to a search for molecular "knobs" that control the nucleocapsid's stability like volume control knobs that can be turned up to hinder virus replication.

The UD team built two molecular dynamics systems of the Ebola nucleocapsid for their study. One included single-stranded RNA; the other contained only the nucleoprotein. The systems were then simulated using the Texas Advanced Computing Center's Frontera supercomputer -- the largest academic supercomputer in the world. The simulations took about two months to complete.

Graduate research assistant Chaoyi Xu ran the molecular simulations, while the entire team was involved in developing the analytical framework and conducting the analysis. Writing the manuscript was a learning experience for Xu and undergraduate research assistant Tanya Nesterova, who had not been directly involved in this work before. She also received training as a next-generation computational scientist with support from UD's Undergraduate Research Scholars program and NSF's XSEDE-EMPOWER program. The latter has allowed her to perform the highest-level research using the nation's top supercomputers. Postdoctoral researcher Nidhi Katyal's expertise also was essential to bringing the project to completion, Perilla said.

While a vaccine exists for Ebola, it must be kept extremely cold, which is difficult in remote African regions where outbreaks have occurred. Will the team's work help advance new treatments?

"As basic scientists we are excited to understand the fundamental principles of Ebola," Perilla said. "The nucleocapsid is the most abundant protein in the virus and it's highly immunogenic -- able to produce an immune response. Thus, our new findings may facilitate the development of new antiviral treatments."

Read more at Science Daily

Prebiotic chemistry: In the beginning, there was sugar

 Organic molecules formed the basis for the evolution of life. But how could inorganic precursors have given rise to them? Ludwig-Maximilians-Universitaet (LMU) in Munich chemist Oliver Trapp now reports a reaction pathway in which minerals catalyze the formation of sugars in the absence of water.

More than 4 billion years ago, the Earth was very far from being the Blue Planet it would later become. At that point it had just begun to cool and, in the course of that process, the concentric structural zones that lie ever deeper beneath our feet were formed. The early Earth was dominated by volcanism, and the atmosphere was made up of carbon dioxide, nitrogen, methane, ammonia, hydrogen sulfide and water vapor. In this decidedly inhospitable environment the building blocks of life were formed. How then might this have come about?

Researchers have puzzled over the question for decades. The first breakthrough was made in 1953 by two chemists, named Stanley Miller and Harold C. Urey, at the University of Chicago. In their experiments, they simulated the atmosphere of the primordial Earth in a closed reaction system that contained the gases mentioned above. A miniature 'ocean' was heated to provide water vapor, and electrical discharges were passed through the system to mimic the effects of lightning. When they analyzed the chemicals produced under these conditions, Miller and Urey detected amino acids -- the basic constituents of proteins -- as well as a number of other organic acids.

It is now known that the conditions employed in these experiments did not reflect those that prevailed on the early Earth. Nevertheless, the Miller-Urey experiment initiated the field of prebiotic chemical evolution. However, it not throw much light on how other classes of molecules found in all biological cells -- such as sugars, fats and nucleic acids -- might have been generated. These compounds are however indispensable ingredients of the process that led to the first bacteria and subsequently to photosynthetic cyanobacteria that produced oxygen. This is why Oliver Trapp, Professor of Organic Chemistry at LMU, decided to focus his research on the prebiotic synthesis of these substances.

From formaldehyde to sugar

The story of synthetic routes from smaller precursors to sugars goes back almost a century prior to the Miller-Urey experiment. In 1861, the Russian chemist Alexander Butlerov showed that formaldehyde could give rise to various sugars via what became known as the formose reaction. Miller und Urey in fact found formic acid in their experiments, and it can be readily reduced to yield formaldehyde. Butlerov also discovered that the formose reaction is promoted by a number of metal oxides and hydroxides, including those of calcium, barium, thallium and lead. Notably calcium is abundantly available on and below the Earth's surface.

However, the hypothesis that sugars could have been produced via the formose reaction runs into two difficulties. The 'classical' formose reaction produces a diverse mixture of compounds, and it takes place only in aqueous media. These requirements are at odds with the fact that sugars have been detected in meteorites.

Together with colleagues at LMU and the Max Planck Institute for Astronomy in Heidelberg, Trapp therefore decided to explore whether formaldehyde could give rise to sugars in a solid-phase system. With a view to simulating the kinds of mechanical forces to which solid minerals would have been subjected, all the reaction components were combined in a ball mill -- in the absence of solvents, but adding enough formaldehyde to saturate the powdered solids

And indeed, the formose reaction was observed and several different minerals were found to catalyze it. The formaldehyde was adsorbed onto the solid particles, and the interaction resulted in the formation of the formaldehyde dimer (glycolaldehyde) -- and ribose, the 5-carbon sugar that is an essential constituent of ribonucleic acid (RNA). RNA is thought to have merged prior to DNA, and it serves as the repository of genetic information in many viruses, as well as providing the templates for protein synthesis in all cellular organisms. More complex sugars were also obtained in the experiments, together with a few byproducts, such as lactic acid and methanol.

Read more at Science Daily

The Milky Way galaxy has a clumpy halo

 The Milky Way galaxy is in the recycling business.

University of Iowa astronomers have determined our galaxy is surrounded by a clumpy halo of hot gases that is continually being supplied with material ejected by birthing or dying stars. This heated halo, called the circumgalactic medium (CGM), was the incubator for the Milky Way's formation some 10 billion years ago and could be where basic matter unaccounted for since the birth of the universe may reside.

The findings come from observations made by HaloSat, one of a class of minisatellites designed and built at Iowa -- this one primed to look at the X-rays emitted by the CGM. The researchers conclude the CGM has a disk-like geometry, based on the intensity of X-ray emissions coming from it. The HaloSat minisatellite was launched from the International Space Station in May 2018 and is the first minisatellite funded by NASA's Astrophysics Division.

"Where the Milky Way is forming stars more vigorously, there are more X-ray emissions from the circumgalactic medium," says Philip Kaaret, professor in the Iowa Department of Physics and Astronomy and corresponding author on the study, published online in the journal Nature Astronomy. "That suggests the circumgalactic medium is related to star formation, and it is likely we are seeing gas that previously fell into the Milky Way, helped make stars, and now is being recycled into the circumgalactic medium."

Each galaxy has a CGM, and these regions are crucial to understanding not only how galaxies formed and evolved but also how the universe progressed from a kernel of helium and hydrogen to a cosmological expanse teeming with stars, planets, comets, and all other sorts of celestial constituents.

HaloSat was launched into space in 2018 to search for atomic remnants called baryonic matter believed to be missing since the universe's birth nearly 14 billion years ago. The satellite has been observing the Milky Way's CGM for evidence the leftover baryonic matter may reside there.

To do that, Kaaret and his team wanted to get a better handle on the CGM's configuration.

More specifically, the researchers wanted to find out if the CGM is a huge, extended halo that is many times the size of our galaxy -- in which case, it could house the total number of atoms to solve the missing baryon question. But if the CGM is mostly comprised of recycled material, it would be a relatively thin, puffy layer of gas and an unlikely host of the missing baryonic matter.

"What we've done is definitely show that there's a high-density part of the CGM that's bright in X-rays, that makes lots of X-ray emissions," Kaaret says. "But there still could be a really big, extended halo that is just dim in X-rays. And it might be harder to see that dim, extended halo because there's this bright emission disc in the way.

"So it turns out with HaloSat alone, we really can't say whether or not there really is this extended halo."

Kaaret says he was surprised by the CGM's clumpiness, expecting its geometry to be more uniform. The denser areas are regions where stars are forming, and where material is being traded between the Milky Way and the CGM.

"It seems as if the Milky Way and other galaxies are not closed systems," Kaaret says. "They're actually interacting, throwing material out to the CGM and bringing back material as well."

The next step is to combine the HaloSat data with data from other X-ray observatories to determine whether there's an extended halo surrounding the Milky Way, and if it's there, to calculate its size. That, in turn, could solve the missing baryon puzzle.

Read more at Science Daily

Paper recycling must be powered by renewables to save climate

 Recycling paper may only be helpful to the climate if it is powered by renewable energy, according to a new modelling study by researchers at UCL and Yale.

The study, published in Nature Sustainability, found that greenhouse gas emissions would increase by 2050 if we recycled more paper, as current methods rely on fossil fuels and electricity from the grid.

The researchers modelled various scenarios for increasing recycling of wastepaper by 2050 and the impact this would have on greenhouse emissions. They found that if all wastepaper was recycled, emissions could increase by 10%, as recycling paper tends to rely more on fossil fuels than making new paper.

However, the researchers found that emissions would radically reduce if paper production and disposal were carried out using renewable energy sources rather than fossil fuels.

Making new paper from trees requires more energy than paper recycling, but the energy for this process is generated from black liquor -- the low-carbon by-product of the wood pulping process. In contrast, paper recycling relies on fuels and electricity from the grid.

Researchers found that modernising landfill practices, for instance by capturing methane emissions and using them for energy, also had a positive effect -- although not as profound as moving to renewables.

Lead author Dr Stijn van Ewijk (UCL Institute for Sustainable Resources and Yale Center for Industrial Ecology) said: "Our study shows that recycling is not a guaranteed way to address climate change. Recycling of paper may not be helpful unless it is powered by renewable energy.

"We looked at global averages, but trends may vary considerably in different parts of the world. Our message isn't to stop recycling, but to point out the risk of investing in recycling at the expense of decarbonising the energy supply and seeing very little change to emissions as a result."

Senior author Professor Paul Ekins (UCL Institute for Sustainable Resources) said: "The recycling of some materials, for instance metals, can lead to a very large reduction in emissions. But we need to be careful about assumptions that recycling, or a circular economy in general, will always have a positive effect on climate change."

The researchers emphasized that recycling has benefits beyond combatting global warming. Co-author Professor Julia Stegemann (UCL Civil, Environmental & Geomatic Engineering) said: "Our exponentially increasing consumption of global resources has many seriously damaging environmental impacts beyond climate change, and conserving resources, including by paper recycling, remains critical for sustainability."

The researchers reported that paper accounted for 1.3% of global greenhouse gas emissions in 2012. About a third of these emissions came from the disposal of paper in landfills. Researchers said that in coming years, use of paper would likely rise, with the move away from plastics leading to increased demand for paper packaging.

The study looked at how different levels of recycling, renewable energy use and more environmentally friendly landfill practices might affect our ability to reduce emissions in line with a target to avoid a 2-degrees Celsius temperature rise by 2050.

It found that if past trends continued, emissions would slightly increase from the 2012 level (721 metric tonnes of carbon dioxide equivalent in a year) to 736 metric tonnes in 2050, with efforts to reduce emissions outweighed by increased demand for paper.

A radical programme of recycling, with landfill and energy uses remaining on the same path, would increase this still further by 10% (to 808 metric tonnes), with savings due to a decrease in total energy use outweighed by an increase in the use of high-carbon electricity.

On the other hand, radically modernising landfill practices would reduce emissions to 591 metric tonnes, while moving to renewables, with recycling and landfill practices remaining on the standard path, would reduce emissions by 96% to 28 tonnes.

Read more at Science Daily

What lies between grey and white in the brain

 Traditionally, neuroscience regards the brain as being made up of two basic tissue types. Billions of neurons make up the grey matter, forming a thin layer on the brain's surface. These neuronal cells are interlinked in a mindboggling network by hundreds of millions of white matter connections, running in bundles, deeper in the brain. Until very recently, not much was known about the interface between the white and grey matter -- the so-called superficial white matter -- because methods were lacking to study it in living human brains. Yet, previous investigations had suggested the region to be implicated in devastating conditions such as Alzheimer's disease and autism. Now a multidisciplinary team led by Nikolaus Weiskopf from the Max Planck Institute for Human Cognitive and Brain Sciences has succeeded in making the superficial white matter visible in the living human brain.

"We demonstrated that the superficial white matter contains a lot of iron. It is known that iron is necessary for the process of myelination," explains Evgeniya Kirilina, first author of the study published in Science Advances. Myelin is what makes the white matter white. It's the fatty coating of nerve cell axons that speeds up transmission of information through the brain. The myelination process can occur throughout the lifespan but is predominant during development. In fact, the largest concentration of iron the researchers found was in the superficial white matter in regions of the frontal cortex, which happens to be the slowest developing structure in the human brain. Incredibly, the human frontal cortex is not fully myelinated until the forth decade of life.

The key to the new method is MRI (Magnetic Resonance Imaging) but at very high field strength. While typical clinical MRI scanners work at 1.5 or 3 Tesla, in terms of the strength of the magnetic field, the Max Planck Institute for Human Cognitive and Brain Sciences houses a powerful 7 Tesla scanner. This, in combination with advanced biophysical model, allowed the team to create very high resolution maps of the white-grey matter border across the entire living brain. The accuracy of their submillimetre maps was assessed against classic and advanced histological methods involving physical dissection and analysis of post mortem brains.

The new method promises many further insights into the organisation of the interface between white and grey matter. Evgeniya Kirilina adds, "We hope the method can be used to increase our understanding of brain development as well as pathological conditions involving the superficial white matter."

From Science Daily

A billion tiny pendulums could detect the universe's missing mass

 

Foucault's pendulum

Researchers at the National Institute of Standards and Technology (NIST) and their colleagues have proposed a novel method for finding dark matter, the cosmos' mystery material that has eluded detection for decades. Dark matter makes up about 27% of the universe; ordinary matter, such as the stuff that builds stars and planets, accounts for just 5% of the cosmos. (A mysterious entity called dark energy accounts for the other 68%.)

According to cosmologists, all the visible material in the universe is merely floating in a vast sea of dark matter -- particles that are invisible but nonetheless have mass and exert a gravitational force. Dark matter's gravity would provide the missing glue that keeps galaxies from falling apart and account for how matter clumped together to form the universe's rich galactic tapestry.

The proposed experiment, in which a billion millimeter-sized pendulums would act as dark matter sensors, would be the first to hunt for dark matter solely through its gravitational interaction with visible matter. The experiment would be one of the few to search for dark matter particles with a mass as great as that of a grain of salt, a scale rarely explored and never studied by sensors capable of recording tiny gravitational forces.

Previous experiments have sought dark matter by looking for nongravitational signs of interactions between the invisible particles and certain kinds of ordinary matter. That's been the case for searches for a hypothetical type of dark matter called the WIMP (weakly interacting massive particles), which was a leading candidate for the unseen material for more than two decades. Physicists looked for evidence that when WIMPs occasionally collide with chemical substances in a detector, they emit light or kick out electric charge.

Researchers hunting for WIMPs in this way have either come up empty-handed or garnered inconclusive results; the particles are too light (theorized to range in mass between that of an electron and a proton) to detect through their gravitational tug.

With the search for WIMPs seemingly on its last legs, researchers at NIST and their colleagues are now considering a more direct method to look for dark matter particles that have a heftier mass and therefore wield a gravitational force large enough to be detected.

"Our proposal relies purely on the gravitational coupling, the only coupling we know for sure that exists between dark matter and ordinary luminous matter," said study co-author Daniel Carney, a theoretical physicist jointly affiliated with NIST, the Joint Quantum Institute (JQI) and the Joint Center for Quantum Information and Computer Science (QuICS) at the University of Maryland in College Park, and the Fermi National Accelerator Laboratory.

The researchers, who also include Jacob Taylor of NIST, JQI and QuICS; Sohitri Ghosh of JQI and QuICS; and Gordan Krnjaic of the Fermi National Accelerator Laboratory, calculate that their method can search for dark matter particles with a minimum mass about half that of a grain of salt, or about a billion billion times the mass of a proton. The scientists report their findings today in Physical Review D.

Because the only unknown in the experiment is the mass of the dark matter particle, not how it couples to ordinary matter, "if someone builds the experiment we suggest, they either find dark matter or rule out all dark matter candidates over a wide range of possible masses," said Carney. The experiment would be sensitive to particles ranging from about 1/5,000 of a milligram to a few milligrams.

That mass scale is particularly interesting because it covers the so-called Planck mass, a quantity of mass determined solely by three fundamental constants of nature and equivalent to about 1/5,000 of a gram.

Carney, Taylor and their colleagues propose two schemes for their gravitational dark matter experiment. Both involve tiny, millimeter-size mechanical devices acting as exquisitely sensitive gravitational detectors. The sensors would be cooled to temperatures just above absolute zero to minimize heat-related electrical noise and shielded from cosmic rays and other sources of radioactivity. In one scenario, a myriad of highly sensitive pendulums would each deflect slightly in response to the tug of a passing dark matter particle.

Similar devices (with much larger dimensions) have already been employed in the recent Nobel-prize-winning detection of gravitational waves, ripples in the fabric of space-time predicted by Einstein's theory of gravity. Carefully suspended mirrors, which act like pendulums, move less than the length of an atom in response to a passing gravitational wave.

In another strategy, the researchers propose using spheres levitated by a magnetic field or beads levitated by laser light. In this scheme, the levitation is switched off as the experiment begins, so that the spheres or beads are in free fall. The gravity of a passing dark matter particle would ever so slightly disturb the path of the free-falling objects.

"We are using the motion of objects as our signal," said Taylor. "This is different from essentially every particle physics detector out there."

The researchers calculate that an array of about a billion tiny mechanical sensors distributed over a cubic meter is required to differentiate a true dark matter particle from an ordinary particle or spurious random electrical signals or "noise" triggering a false alarm in the sensors. Ordinary subatomic particles such as neutrons (interacting through a nongravitational force) would stop dead in a single detector. In contrast, scientists expect a dark matter particle, whizzing past the array like a miniature asteroid, would gravitationally jiggle every detector in its path, one after the other.

Noise would cause individual detectors to move randomly and independently rather than sequentially, as a dark matter particle would. As a bonus, the coordinated motion of the billion detectors would reveal the direction the dark matter particle was headed as it zoomed through the array.

To fabricate so many tiny sensors, the team suggests that researchers may want to borrow techniques that the smartphone and automotive industries already use to produce large numbers of mechanical detectors.

Thanks to the sensitivity of the individual detectors, researchers employing the technology needn't confine themselves to the dark side. A smaller-scale version of the same experiment could detect the weak forces from distant seismic waves as well as that from the passage of ordinary subatomic particles, such as neutrinos and single, low-energy photons (particles of light).

The smaller-scale experiment could even hunt for dark matter particles -- if they impart a large enough kick to the detectors through a nongravitational force, as some models predict, Carney said.

"We are setting the ambitious target of building a gravitational dark matter detector, but the R&D needed to achieve that would open the door for many other detection and metrology measurements," said Carney.

Read more at Science Daily

Ground-breaking discovery finally proves rain really can move mountains

 

Paro Taktsang temple complex in Bhutan

A pioneering technique which captures precisely how mountains bend to the will of raindrops has helped to solve a long-standing scientific enigma.

The dramatic effect rainfall has on the evolution of mountainous landscapes is widely debated among geologists, but new research led by the University of Bristol and published today in Science Advances, clearly calculates its impact, furthering our understanding of how peaks and valleys have developed over millions of years.

Its findings, which focused on the mightiest of mountain ranges -- the Himalaya -- also pave the way for forecasting the possible impact of climate change on landscapes and, in turn, human life.

Lead author Dr Byron Adams, Royal Society Dorothy Hodgkin Fellow at the university's Cabot Institute for the Environment, said: "It may seem intuitive that more rain can shape mountains by making rivers cut down into rocks faster. But scientists have also believed rain can erode a landscape quickly enough to essentially 'suck' the rocks out of the Earth, effectively pulling mountains up very quickly.

"Both these theories have been debated for decades because the measurements required to prove them are so painstakingly complicated. That's what makes this discovery such an exciting breakthrough, as it strongly supports the notion that atmospheric and solid earth processes are intimately connected."

While there is no shortage of scientific models aiming to explain how the Earth works, the greater challenge can be making enough good observations to test which are most accurate.

The study was based in the central and eastern Himalaya of Bhutan and Nepal, because this region of the world has become one of the most sampled landscapes for erosion rate studies. Dr Adams, together with collaborators from Arizona State University (ASU) and Louisiana State University, used cosmic clocks within sand grains to measure the speed at which rivers erode the rocks beneath them.

"When a cosmic particle from outer space reaches Earth, it is likely to hit sand grains on hillslopes as they are transported toward rivers. When this happens, some atoms within each grain of sand can transform into a rare element. By counting how many atoms of this element are present in a bag of sand, we can calculate how long the sand has been there, and therefore how quickly the landscape has been eroding," Dr Adams said.

"Once we have erosion rates from all over the mountain range, we can compare them with variations in river steepness and rainfall. However, such a comparison is hugely problematic because each data point is very difficult to produce and the statistical interpretation of all the data together is complicated."

Dr Adams overcame this challenge by combining regression techniques with numerical models of how rivers erode.

"We tested a wide variety of numerical models to reproduce the observed erosion rate pattern across Bhutan and Nepal. Ultimately only one model was able to accurately predict the measured erosion rates," Dr Adams said.

"This model allows us for the first time to quantify how rainfall affects erosion rates in rugged terrain."

Research collaborator Professor Kelin Whipple, Professor of Geology at ASU, said: "Our findings show how critical it is to account for rainfall when assessing patterns of tectonic activity using topography, and also provide an essential step forward in addressing how much the slip rate on tectonic faults may be controlled by climate-driven erosion at the surface."

The study findings also carry important implications for land use management, infrastructure maintenance, and hazards in the Himalaya.

In the Himalaya, there is the ever-present risk that high erosion rates can drastically increase sedimentation behind dams, jeopardising critical hydropower projects. The findings also suggest greater rainfall can undermine hillslopes, increasing the risk of debris flows or landslides, some of which may be large enough to dam the river creating a new hazard -- lake outburst floods.

Dr Adams added: "Our data and analysis provides an effective tool for estimating patterns of erosion in mountainous landscapes such as the Himalaya, and thus, can provide invaluable insight into the hazards that influence the hundreds of millions of people who live within and at the foot of these mountains."

The research was funded by the Royal Society, the UK Natural Environmental Research Council (NERC), and the National Science Foundation (NSF) of the US.

Building on this important research, Dr Adams is currently exploring how landscapes respond after large volcanic eruptions.

"This new frontier of landscape evolution modelling is also shedding new light on volcanic processes. With our cutting-edge techniques to measure erosion rates and rock properties, we will be able to better understand how rivers and volcanoes have influenced each other in the past," Dr Adams said.

Read more at Science Daily